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放射線照射가 白鼠顎骨 및 拔齒創 治癒에 미치는 影響에 關한 實驗的 硏究
李義雄 연세대학교 대학원 1980 延世論叢 Vol.16 No.2
This study was undertaken to observe in jaws and extraction-wound healing of rats when exposed to a single dose and fractionated dose of Cobalt-60 irradiation. One hundred-sixty albino rats of a sprague dawley strain, weighing approximately 180 grams each at the begining of the experiment were divided into control group and 3 experimental groups. In experimental groups, group I recieved 1200 rads every week until the 4800 rads reached, group II recieved 2000 rads with a single dose and group III recieved 2500 rads with a single dose. Irradiation was carried out using a RAC-120 Cobalt-60 Teletherapy Unit with a dose rate 62.1 r/min measured at 100cm from source. All animals of III group were died from 8th to 12th day after radiation. Group I and II were divided into 4 subgroups after radiation respectively. Extraction on lower third molar was performed in each group at 1st, 2nd, 3rd and 4th week after exposure. Serial sacrifice of two or three experimental and two control animals was begun one week after extraction and was performed on a weekly basis thereatfter until all experimental arimal were used. When all animals were sacrificed, the following specimens available for hislologic study; Control group; 3,7,10,14,21,28,35 and 42 days postextraction, Group I & II were shown as Figure. After examination and comparision of all specimens, the results of this study were obtained as follow. 표삽입 원문참조 1. The mortality during this experimental period were shown, group I : 50%, group II : 43.75% and group III : 100%. 2. The time when all experimental animals began to recover as normal, appearance group I : from 3 weeks after radiation. group II : from 5 weeks after radiation. 3. Osteoradionecrosis of jaw bone appeared to result primarily from the direct effect of irradiation on the osteocyte, revealed pyknosis and loss of ostescyte, and appeared congestion of blood vessels and thickening the Vessel walls. 4. Subgroup A, and C of group I and A of group II showed pyknosis and loss of osteocyte in bone lacunae, especially 1 week after extraction. 5. Extraction-wound healing in subgroup B. and C of group II took as normal healing process, but subtroup A of group I only continued necrotic process upto 4 weeks post extraction. 6. Extraction-wound healing was in direct relationship to total dosage of radiation and the time interval for extraction after radiation. 7. Epithelization of extraction-wound was influenced by size of wound, mucosal laceration and remained foreign body. 8. General condition after radiation leas improved by tube feeding with milk. -supportive therapy. 9. when teeth are extract following radiation, the time interval for extraction after radiation must be taken two weeks at least.
이의웅,박형식,차인호,김진,Lee, Eui-Wung,Park, Hyung-Sik,Cha, In-Ho,Kim, Jin Korean Association of Maxillofacial Plastic and Re 1991 Maxillofacial Plastic Reconstructive Surgery Vol.13 No.2
In 1977, Robinson & Martinez described a distinct varient of ameloblastomas in which the response to curettage was found to be favorable, with a recurrence rate of 25%. They referred to this varient as unicystic ameloblastoma. Unicystic ameloblastoma occur most commonly in the second and third decades of life, which is considerablly younger than the average age of discovery for the classical ameloblastoma. For the accurate histopathological diagnosis of the unicystic ameloblastoma, the specimen obtained the excisional biopsy, complete enucleation or incisional biopsy from the multiple site of the lesion. The purpose of this report is to review of the literature and to present three cases in which an unicystic ameloblastoma appear to be arising in the wall of a dentigerous cyst. 치성낭종과 법랑아세포종과의 조직학적 기준이 모호한 경우에 과거에는 병리학자들이 진단하는데 어려움이 많았으나 1970년 Robinson & Martinez가 조직학적 기준을 제시하면서 unicystic ameloblastoma라 명명하였다. Unicystic ameloblastoma는 conventional ameloblastoma 보다 젊은 연령인 10대, 20대에서, 하악 제3대구치부에서 호발하며 방사선학적으로 단방성 혹은 다방성의 비교적 경계가 뚜렷한 방사선 투과성 병소를 보인다. 이 병소는 적출술만으로 치료하였을 때 solid or multicystic ameloblastoma보다 현저히 낮은 재발율을 보인다. 임상적, 방사선학적으로 unicystic ameloblastoma가 의심되면 병소를 완전히 적출하여 정확한 병리조직학적 진단을 하여 solid or multicystic ameloblastoma일 때는 2차적으로 광범위한 수술 등을 고려하는 것이 타당할 것으로 사료되어 문헌고찰과 함께 3증례의 치료 경험을 보고하는 바이다.