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알레르기성 비염을 앓고 있는 천식환아에서의 피부검사 양성 항원으로 실시한 비점막유발시험 - 제1차 보고
이기영,정병주,김규언 대한천식알레르기학회 1989 천식 및 알레르기 Vol.9 No.3
In seventy-eight atopic asthmatic children suffering from allergic rhinitis, 176 nasal provocation tests were performed with various allergens which gave positive or strong positive reactions on allergy skin test. After O.lml of allergen was instilled into the nostril by tuberculine syringe, the nasal allergic reaction was classified as mild, moderate or severe according to the degree of itching or sneezing, rhinorrhea and obstruction at 5 minute interval for 20 minutes. The results were as follows. 1. Allergic diseases present in the patients other than allergic rhinitis were as follows. There were 36 cases of conjunctivitis(46.2%), followed by 13 cases of urticaria(16.6%), 9 cases of EIA(11.5%), 8 cases of atopic dermatitis(10.3%) and 4 cases of food allergy(5.1%). 2. There was a family history of allergic diseases in 42 cases(53.8%). 3. Of the total 176 tests, positive nasal provocatios occurred in 87 cases(49.4%). Patients with strong positive allergy skin test showed a 58.3% provocation rate compared to 26.5% in the positive allergy skin test group. 4. Among individual allergens, the provocation rates were 88.9%, 71.4%, 57.8% and 41.7% cockroach, alternaria, D. farinae and house dust respectively, but 36.7% in the other 19 allergens. 5. Eighty-nine nasal provocation tests were done on 39 cases who have been receiving immunot- herapy for more than 1 1 / 2 years. The group with excellent improvement after immunotherapy had a lower provocation rate(28.6%) than the group with fair improvement(78.6%). According to the above findings, the result of the nasal provocation test with allergen had a good correlation with the results of the allergy skin test in cockroach, alternaria and D. farinae, and may be a valuable objective index for monitoring immunotherapy.