초청설교 : 넉넉히 구원 얻는 삶 : 이신웅

이신웅 기독교대한성결교회 활천사 2016 활천 Vol.749 No.4

Neostigmine이 Atropine 處理 家兎의 血歷에 미치는 影響

李神雄,李壽根,陳甲德 영남대학교 자원문제연구소 1984 資源問題硏究 Vol.3 No.-

The intravenous injection of neostigmine produced a rise in blood pressure in atropinized rabbits. This pressor response was markedly inhibited by phentolamine, reserpine or hexamethonium but was not affected by hemicholinium. The injection of neostigmine into the lateral cerebral ventricle evoked a hypertensive response which could be reduced by the previous administration of atropine, intraventricular hemich-olinium, phentolamine or reserpine, but not by methylatropine. It is concluded that the pressor response of intravenous neostigmine in atropinized rabbits is due to direct stimulant action on the sympathetic ganglia, which is distinct from its anticholinesterase action and central hypertensive effect.

家兎 側腦室內 Physostigmine의 利尿效果에 關한 硏究

李神雄,孫基鎬 영남대학교 자원문제연구소 1984 資源問題硏究 Vol.3 No.-

Effect of intraventricular physostigmine on the renal function of rabbits was investigated. The results were as follows. 1. Intraventricular Physostigmine (below 0.3㎍ per rabbit) did not affect the renal function but induced diuretic action in does ranging 10㎍ to 100㎍ per rabbit, exhibited a rough dose-response relationship, and increased renal plasma flow, glomerular filtration rate, urinary excretion of sodium and potassium, concomitant with increased urine flow. On the other hand, intraventricular physostigmine did not influence to filtration fraction and reabsorption of sodium and potassium. 2. Correlation coefficient among the increased urine flow, renal plasma flow and glomerular filtration rate was statistically significant. 3. Intravenous physostigmine (100㎍) did not affect the renal function. 4. Parameters of renal function increased by intraventricular physostigmine were inhibited by intravenous atropine (2mg/kg) or bilateral vagotomr. These results suggest that the diuretic effects of intraventricular physostigmine in rabbit is mainly due to hemodynamic changes by centrally induced cholinergic mechanism on the kidney.

Effect of Bay K 8644, a Calcium Chaanel Agonist, on Dog Cardiac Muscarinic Receptors : Lee, Shin Woong Park, Young Joo Lee, Jeung Soo

이신웅,박영주,이정수 영남대학교 약품개발연구소 1992 영남대학교 약품개발연구소 연구업적집 Vol.2 No.-

To investigate further whether the effects of the dihydropyridine (DHP) drugs on calcium channels are related to those of these drugs on muscarinic receptors, the binding characteristics of the DHP calcium channel agonist, Bay K 8644, on muscarinic receptors and calcium channels were compared to those of the DHP calcium channel antagonists, nicardipine and nimodipine in the dog cardiac sarcolemma. Bay K 8644, nicardipine and nimodipine inhibited the specific [³H]QNB binding with K_(i) values of 16.7 μM, 3.5 μM and 15.5 μM respectively. Saturation data of [³H]QNB binding in the presence of these DHP drugs showed this inhibition to be competitive. Bay K 8644, like nicardipine and nimodipine, blocked the binding of [³H]nitrendipine to the high affinity DHP binding sites, but atropine did not, indicating that the muscarinic receptors and the DHP binding sites on calcium channels are distinct. The K_(i) value of Bay K 8644 for the DHP binding sites was 4 nM. Nicardipine and nimodipine (K_(i) : 0.1-0.2 nM) were at least 20 times more potent than Bay K 8644 in inhibiting [³H]nitrendipine binding. Thus, the muscarinic receptors were about 4000 times less sensitive than these high affinity DHP binding sites to Bay K 8644. These results suggest that the DHP calcium agonist Bay K 8644 binds directly to the muscarinic receptors but its interaction with the muscarinic receptors is not related to its binding to the DHP binding sites on calcium channels.

자궁 Muscarinic Receptor에 관한 연구 : Receptor결합실험과 기능적실험과의 상관성 elationship between functional and Receptor-Binding Data

이신웅 영남대학교 자원문제연구소 1993 資源問題硏究 Vol.12 No.-

Using a receptor binding technique, with ℓ-quinuclidinyl benzilate(QNB) as a radioligand, we have classified the cholinergic muscarinic receptors In the unpregnant uterus of dog into M2 receptors. This study was carried out to elucidate whether the previous binding data correlate with data from pharmacological studies of uterus strips. Carbachol and methacholine, muscarinic receptor agonists, increased the motility and contractile force of uterus with ED50alue of 2.6 and 3.0 #d. respectively. Atropine and pirenzepine caused the rightward shift of the concentration-response curve to carbachol. With these antagonists, the slopes of the Schild plots were not significantly different from the theoretical value of one, indicating competitive antagonism. The dissociation constants(KA) of atropine and pirenzepine estimated by Schild analysis were 0.6nM and 213nM, respectively. The ED50values of agonists and KAvalues of antagonists correlated with K values determined by the radioligand binding technique. These results suggest that the binding of the muscarinic agonists and antagonists including[3H]QNB to the uterus represents an interaction with a receptor of physiological relevance.

항 히스타민제의 H₁ 수용체와 무스카린 수용체에 대한 상대적 역가

이신웅,박영주,이정수 영남대학교 약품개발연구소 1994 영남대학교 약품개발연구소 연구업적집 Vol.4 No.-

The muscarinic antagonist l-[benzilic-4, 4'-³H]quinuclidinyl benzilate([³H]QNB) bound to a single class of muscarinic receptor with high affinity in guinea pig ileal membranes. The K_(D) and B_(max) values for [³H]QNB calculated from analysis of saturation isotherms were 54 pM and 156 fmol/mg, respectively. H₁-blockers inhibited [³H]QNB binding to ileal membranes with K_(i) values ranged from 0.008 μM to 1.6 μM. The pseudo-Hill coefficients of H₁-blockers for inhibition of [³H]QNB binding to the ileal membranes were close to unit. The K_(i) values for H₁-blockers were similar to the K_(M) values calculated by Schild plot of functional data obtained from inhibition of the carbachol-induced contraction in guinea-pig ileum, suggesting that binding of H₁-blockers vs [³H]QNB in ileal membranes represents an interaction with a receptor of physiological relevance. The K_(H) values of H₁-blockers for H₁-receptor estimated from inhibition of the histamine-induced contraction were the range of 0.15 nM to 56.5 nM. The K_(M)/K_(H) ratio of H₁-blockers varied over a wide range of 3 to 2300. Thus, the antihistaminic potencies of H₁-blockers do not correlate with their antimuscarinic potencies, which suggest that antihistamines have different antimuscarinic potencies in therapeutic blood levels causing similar antiallergic effect. Among 13 traditional antihistaminics examined in this study, drug having the highest and the lowest K_(M)/K_(H) ratio is triprolidine and diphenidol, respectively. The present results demonstrate that the antimuscarinic property of antihistamines is not necessary for their antiallergic effect, and data on the affinity of antihistamines for muscarinic and H₁-receptors can be an important parameter in the selection and evaluation of these drugs.

Korean EFL University Students’ English Vocabulary Size and Their Writing Proficiency

이신웅 한국영어교과교육학회 2014 영어교과교육 Vol.13 No.2

The purpose of the current study was two-fold. It was to measure the receptive and productive vocabulary size of Korean university students and to examine their English writing ability in relation to their productive vocabulary size. Ninety seven Korean EFL students at a university located in Seoul participated in the current study. Their vocabulary sizes were measured by the Receptive Vocabulary Size Test (RVST), an adapted version of Vocabulary Size Test (VST) (Nation & Beglar, 2007) and the Productive Vocabulary Size Test (PVST) developed by Shin, Chon, and Kim (2011). The students’ essays were then assessed using the ESL Composition Profile (Jacobs, Hartfiel, Hughey, & Wormuth, 1981). The estimates of receptive and productive vocabulary sizes of the students were 7,906 and 5,436 word families respectively, and the overall ratio of the productive vocabulary size to the receptive vocabulary size was .68, which indicated that the students were able to use 68.76% of the vocabulary that they could comprehend. In addition, the result of a multivariate analysis of variance (MANOVA) revealed that the students’ productive vocabulary size had a significant effect on the four aspects of their writings: content, language use, vocabulary, and mechanics.

University Students’Experiences of Peer-Assisted Learning (PAL) and Its Effect on Their Academic Achievement

이신웅 팬코리아영어교육학회 2009 영어교육연구 Vol.21 No.2

The main purpose of the study was to explore university students’ experiences in two different types of learning contexts (peer-assisted learning vs. teacher-led instruction) in an English-medium course and to see whether there was an effect of peer-assisted learning on their academic achievement. Seventy nine students in two English grammar classes at a university located in Seoul participated in the study. The students in one class had a 45-minute-long peer tutoring session in a group of 4 or 5 every week totalling 12 sessions, while the other class did not receive peer tutoring treatment. At the end of the semester, a survey on the students’ experiences was administered in the two classes and an in-depth semi-structured interview was conducted to explore the students’ experiences. In addition, the academic achievement in the two different learning contexts were compared and tested using analysis of covariance (ANCOVA) to see if there was any effect of peer tutoring treatment. The results of the study indicated that the students usually had more positive experiences in +PAL context than in -PAL context in general and there was a significant effect of peer tutoring on their academic achievement. In relation to the students’ experiences, five themes were identified: community of learning, language proficiency, feedback and knowledge reconstruction, teaching as a learning strategy, and work overload.

Rat腎臟에서 High Affinity [³H]Ouabain Binding Site의 缺如

李神雄 영남대학교 자원문제연구소 1984 資源問題硏究 Vol.3 No.-

I50 value for inhibition by ouabain, turnover number, and (3H) ouabain binding of cardiac sarcolemmal Na+, K+-ATPase were compared to those of kidney microsome in rat. The I50value (50~60?M) and turnover number were same for both subcellular fraction. The KD value and binding site concentration (Bmax) calculated by displacement assay for ouabain binding of cardiac sarcoleinma in presence of 0.1-0.2 ?M [3H] ouabain were 0.33±0.05?M and 8.7±0.6 pmol/mg protein, respectively, but the binding in vitro of [3H]ouabainto kidney microsomal Na+, Kl+-ATPase was not detected. These data suggest that rat kidney has low affinity site but not detectable high affinity site to ouabain which can be detected inrat heart.

Thinking 함께 생각하고 : 나의 장례설교 ; 주는 대대에 우리의 거처: 시편 90:1-10

이신웅 기독교대한성결교회 활천사 2007 활천 Vol.649 No.-