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5HT 2A/T102C 다형성과 정신분열병 및 임상아형과의 관련연구
홍현상,백인호,김정진,이창욱,이 철,도규영 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.4
목 적 : 가계연구, 입양연구, 쌍생아연구들은 정신분열병의 원인으로 유전학적 요소가 매우 중요하다는 것을 지적해 주고 있다. 그러나 정신분열병의 유전적인 복잡성으로 인하여 많은 연구들이 시행되었음에도 유전방식이나 원인 유전자를 밝히지는 못하였다. 최근에는 5HT₂a수용체가 비정형항정신병약물의 주된 작용부위하는 것이 밝혀지면서 5HT₂a 수용체의 유전자가 정신분열병의 원인과 관련이 있을 것이라는 관심이 늘어나게 되었다. 따라서 저자들은 한국인 정신분열병환자들을 대상으로 5HT₂a 수용체 T102C 다형성과의 association study를 시행하였다. 방 법 : 환자군은 강남성모병원에 입원했던 DSM-Ⅲ-R의 진단기준에 의한 정신분열병환자로 250명이었으며 평균연령은 30.1±9.3세 이었다. 정신분열병환자를 위한 양성증상과 음성증상척도의 종합척도를 기준으로 점수가 1이상인 경우를 양성군, -1이하인 경우를 음성군으로 하였다. 대조군은 정신과나 신경과 질환의 과거력이나 가족력이 없는 236명의 지원자로 구성하였으며 평균연령은 23.6±3.7세이었다. 다형성과 정신분열병 및 임상양상과 임상아형 사이의 유전적인 관련성의 분석에는 로지스틱 회귀분석과 일원 변량분석을 시행하였으며 통계 프로그램으로는 SPSS 7.5를 사용하였다. 말초혈액에서 DNA를 분리한후 중합효소 연쇄반응으로 증폭하였으며, 증폭산물을 제한효소인 MspI으로 처리하여 유전자형을 판별하였다. 결 과 : 5HT₂a 수용체 T102C 다형성의 대립유전자 빈도와 유전자형 분포는 환자군과 대조군 사이에 유의한 차이를 보여주지 못하였으며, 임상아형과도 유의한 관련이 없는 것으로 나타났다. 그러나 정신분열병환자를 위한 양성증상과 음성증상척도중 음성증상척도는 유전자형에 따른 유의한 차이를 나타내었다(F=3.828, df=2, p=0.023). 결 론 : 본 연구의 결과는 한국인에서 5HT₂a 수용체의 T102C 다형성이 정신분열병의 발생과 임상아형의 결정에는 관련이 없으나 음성증상의 발현에는 관련이 있음을 시사해 준다고 하겠다. Objectives : Family, twin and adoption studies indicate that genetic factors play a crucial role in the etiology of schizophrenia. However, mode of inheritance of schizophrenia is uncertain, and genes for schizophrenia have not yet been identified despite extensive studies due to the complexity of the genetics of schizophrenia. Currently, 5HT₂a receptor gene has attracted considerable interest as a susceptibility gene of schizophrenia since the 5HT₂a receptor has been known as one of the major target sites of atypical neuroleptics. We conducted an association study of T102C polymorphism in the 5HT₂a receptor gene in Korean schizophrenic patients using PCR-RELP method. Methods : Two hundred and fifty biologically unrelated schizophrenic patients meeting DSM-Ⅲ-R criteria from Kangnam St. Mary's Hospital affiliated with Catholic University of Korea were recruited for our study. The patient group consisted of 123 male and 127 female subjects, aged 30.1±9.3years. The controls were volunteers for DNA library of Kangnam St. Mary's Hospital without family history of psychiatric or neurologic illness. The control group consisted of 124 males and 112 females, aged 23.6±3.7years. Amplified genomic DNA was digested by MspI. The significance of genetic association of the polymorphism was estimated by the logistic regression analysis and ANOVA using SPSS 7.5. Results : The allele frequencies and the genotypic distribution of 5HT₂a receptor gene were not significantly different between the patient and control group. In addition the allele frequencies and the genotypes of 5HT₂a receptor gene were not significantly associated with subtype of schizophrenia. However, negative symptom score according to genotype show significant difference(F=3.828 df=2 p=0.023). Conclusion : It is suggested that even if the development and subtype of schizophrenia may not be associated with T102C polymorphism of 5HT₂a receptor in Korean population, T102C polymorphism may be associated with the severity of negative symptom.
고 아밀라아제 혈증을 보인 급성 Lithium Carbonate 중독증 1례
홍현상,박흥수,정염성,노왕구 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.2
Lithium carbonate is a widely used and invaluable drug in the treatment and prevention of manic-depressive illness. However, lithium cardonate may induce multisystemic adverse effects and toxic effects that, when not recognized, may lead to severe, life-threatening complications. The authors experienced a manic patient who showed severe lithium toxic reactions with hyperamylasemia. The patient was 41-year-old woman who had received lithium carbonate treatment for 3 months. The patient's symptoms and signs of toxic reaction had disappeared after hydration, insulin therapy, and hemodialysis.
홍현상,채영래,백인호 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.6
It has been thought that the onset of schizophrenia is limited to youth. However, many European investigators have reported the occurrence of schizophrenia in later life. They have noted that the symptoms found in late-onset schizophrenia are not different from those noted in patients with early-onset schizophrenia. With the advent of the DSM-III-R(1987), there has been a renewal of interest in schizophrenia that arise for the first time in late life. This study was designed to examine some characteristic findings on demographics, clinical features, and treatment response in late-onset schizophrenia. The subjects consisted of 36 patients with late-onset(after 40) schizophrena and 72 patients with early-onset schizophrenia(before 40) by DSM-III-R who were admitted to the Department of Neuropshcyiatry of Kangnam St. Mary's Hospital, Catholic University Medical College from March 1982 to July 1990 The results were as follows : 1) The male to female ratio of the late-onset schizohprenic patients was 1 : 5. 2) The patients with late-onset schizophrenia were more likely to have grandiose delusions and auditory hallucinations than those of early-onset schizophrenia. 3) There was no significant difference in frequenty of clinical symptoms such as loosening of association, inappropriate affect, catatonia and response to neuroleptic treatment among each group. In light of these results, it seems likely that late-onset schizophrenia is somewhat different from, or might be a subtype of, more typical schizophrenia.
고 아밀라아제 혈증을 보인 급성 Lithium Carbonate 중독증 1예
정현성,홍현상,노왕구,박흥수 대한신경정신의학회 1991 신경정신의학 Vol.30 No.2
Lithium carbonate is a widely used and invaluable drug in the treatment and prevention of manic-depresive illness. However, lithium cardonate may induce multisystemic adverse effects and toxic effects that, when not recognized, may lead to severe, life-threatening complications. The authors experienced a manic patient who showed severe lithium toxic reactions with hyperamylasemia. The patient was 41-year-old woman who had received lithium carbonate treatment for 3 months. The patient,s symptoms and signs of toxic reaction had disappeared after hydration, insulin therapy, and hemodialysis.
전외 액츄에이터용 PBZT 세라믹스의 $WO_3$ 첨가에 따른 특성
김규수,윤광희,윤현상,박창엽,홍재일,류주현 한국전기전자재료학회 1997 電氣電子材料學會誌 Vol.10 No.9
To improve the electro-induced strain and to decease the hysteresis of that W $O_3$dopant of which amount is 0~0.8wt% was added to (P $b_{0.73}$/B $a_{0.27}$)(Z $r_{0.75}$/ $Ti_{0.25}$) $O_3$+0.1wt% $Y_{2}$/ $O_3$ceramics. At the specimen with 0.4 wt% W $O_3$the electromechanical coupling coefficient( $K_{31}$ ) showed the maximum value of 23.6% at D.C 10 kV/cm electric field. At the same W $O_3$addition amount the piezoelectric constant( $d_{31}$ ) and the electro-induced strain($\Delta$$\ell$/$\ell$)showed the highest values of 182$\times$10$^{-12}$ [C/N] 210$\times$10$^{-6}$ $\Delta$$\ell$/$\ell$at D.C. 10 kV/cm electric field. respectively0 kV/cm electric field. respectivelyvely.