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장보라,홍철암,이혁진 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
A large-scale production of DNA nanostructures for siRNA delivery has been achieved by an isothermal enzymatic process of rolling circle amplification (RCA). Our system allowed the preparation of more than 200-fold of amplified DNA products using a ss circular DNA template. Y-shaped DNA nanostructures with sticky overhangs, which can hybridize with siRNAs, were generated through the programmed molecular self-assembly. The DNA nanostructures loaded with folate conjugated-siRNAs showed enhanced cellular uptake as well as dose-dependent gene silencing.
Self-assembled DNA nanostructures prepared by rolling cirlce amplification for siRNA delivery
장보라,홍철암,이혁진 한국공업화학회 2014 한국공업화학회 연구논문 초록집 Vol.2014 No.1
A large-scale production of DNA nanostructures for siRNA delivery has been achieved by an isothermal enzymatic process of rolling circle amplification (RCA). Our system allowed the preparation of more than 200-fold amplified DNA products using ss circular DNA template. Y-shaped DNA nanostructures with sticky overhangs, which can hybridize with siRNAs, were generated through the programmed molecular self-assembly. The DNA nanostructures loaded with folate conjugated-siRNAs showed enhanced cellular uptake as well as dose-dependent gene silencing.