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전신성 홍반성 루푸스에서 IL-1α에 의한 항혈관내피세포항체 결합능의 증가
홍연식 ( Yeon Sik Hong ),김완욱 ( Wan Uk Kim ),민준기 ( Jun Ki Min ),박성환 ( Sung Hwan Park ),이상헌 ( Sang Heon Lee ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ) 대한류마티스학회 1998 대한류마티스학회지 Vol.5 No.1
Systemic lupus erythematosus(SLE) is a multiorgan disease which is associated with the occurrence of immune vascular damage. Antiendothelial cell antibodies(aECA) have been demonstrated in patients with SLE, and their presence could be related to vascular injury. Endothelial cell(EC) in vasculitic lesions of patients with SLE show evidence of activation. In vitro treatment of EC with cytokines can produce a pattern of activation such as the increased expression of surface molecules. Activation of EC was shown to influence the interaction between aECA and endothelial surface. The authors, therefore, examined the prevalence of IgG aECA and investigated the association of aECA with clinical findings and anticardiolipin antibodies(aCL). We also investigated the role of cytokine in binding of IgG-aECA to EC in patients with SLE. Sera from 92 patients with SLE and 20 healthy controls were assayed for IgG-aECA by cellular ELISA method using cultured human umbilical vein endothelial cell (HUVEC) and IgG-aCL by ELISA method, and We also examined the binding of IgG-aECA to EC activated with IL-1α or TNF-α in sera from 60 patients with SLE. IgG-aECA was detected in the serum of 31 out of 92 patients(33.7%). The mean serum titers of IgG-aECA were significantly higher in SLE than in healthy controls(19.38 U/ml vs 8.79 U/ml, P<0.05). There was no correlation between serum titers of IgG-aECA and IgG-aCL(r=-0.0265). The mean serum titers of IgG-aECA in patients with digital vasculitis or Raynaud`s phenomenon were significantly increased in comparison with patients without these manifestations(35.28 U/ml vs 18.16 U/ml, P<0.05. 27.18 U/ml vs 15.24 U/ml, P<0.05 respectively). The mean serum titers of IgG-aECA in 60 patients were significantly increased (P<0.0001) following the stimulation with IL-1α as compared with unstimulated EC, but those of IgG-aECA were not increased following the stimulation with TNF-α. The IgG-aECA binding reactivity to IL-1α stimulated EC was significantly higher in patients with digital vasculitis, Raynaud`s phenomenon, renal disorder, thrombosis, neuropsychiatric manifestation and avascular necrosis as compared with unstimulated EC. IgG-aECA was detected in 28 of the 60 patients(46.7%). Its frequency was increased following the stimulation with IL-1α(68.3%), but there was no significant difference in frequency following the stimulation with TNF-α(48.3%). These data suggest that presence of IgG-aECA and enhanced binding of IgG-aECA to EC induced by IL-1α can play an important role in the occurrence of clinical manifestations associated with vascular damage in SLE.
홍연식 ( Yeon Sik Hong ),김완욱 ( Wan Uk Kim ),이신석 ( Shin Seok Lee ),주영실 ( Yeong Sil Zoo ),민준기 ( Jun Ki Min ),박성환 ( Sung Hwan Park ),이상헌 ( Sang Heon Lee ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ) 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.2
Objective: To investigate the efficacy and safety of oral bovine type II collagen(CII) in the treatment of rheumatoid arthritis(RA). Methods: Forty-five patients with active RA were enrolled and randomized to receive placebo or oral CII for 3 months. Efficacy parameters were assessed monthly. Cumulative response rates(percentages of patients meeting the criteria for response at anytime during the study) were analyzed utilizing 3 set of composite criteria: Paulus criteria, ACR criteria for improvement in RA, and a requirement for≥30% reduction in both swollen and tender joint counts. Results: The CII-treated group(n=25) showed significant higher response rate by the Paulus criteria compared to placebo group(n=20) (p=0.04), and MHAQ scores between baseline and 3 months of treatment were also significantly decreased in the CII-treated group(p<0.05). However, there were no significant differences in tender and swollen joint count, and physician and patient global scores between CII-treated and placebo groups. Only one patient treated with CII had a urticarica 1 week after administration, but no serious side effects were found in the two groups. Patients treated with CII(n=15) showed the decreased levels of circulating IgG antibodies to bovine CII 3 months after treatment(p=0.02), whereas significant changes of IgG antibodies to CII were not found in placebo group(n=12). Conclusion: Oral administration of CII was safe and effective for the treatment of rheumatoid arthritis. The finding that serum IgG antibodies to bovine CII was decreased in patients who treated with CII suggest that autoimmune response to CII could be decreased by repetitive administration of CII.
Acroosteolysis가 동반된 Sjogren`s 증후군
홍연식 ( Yeon Sik Hong ),양형인 ( Hyung In Yang ),박성환 ( Sung Hwan Park ),이상헌 ( Sang Heon Lee ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ) 대한류마티스학회 1996 대한류마티스학회지 Vol.3 No.1
Acroosteolysis (AOL) refers to a destructive process involving distal phalangeal shaft while the tuft and base are preserved. It can be a manifestation of various diseases, such as scleroderma, Raynaud`s disease, rheumatoid vasculitis, psoriasis, renal osteodystrophy and leprosy. Occupational exposure to polyvinyl chloride polymers, thermal injury, and repetitive mechanical injury can also cause this problem. Although the exact pathogenesis of AOL is uncertain, a unifying theme of vascular and mechanical injury is presented. Recently, we experienced a 32-year-old woman complained of xerophthalmia, zerostomia and polyarthralgia which was diagnosed as Sjogren syndrome associated with acroosteolysis. After administration of prednisolone, cyclophosphamide and oral bromhexine, subsidence of her symptoms was observed. We report this case with a review of relevant literature.
5종 농약에 대한 4종 담수조류(freshwater algae)의 감수성 비교
박연기(Yeon-Ki Park),김병석(Byung-Seok Kim),배칠한(Chul-Han Bae),김연식(Yeon-Sik Kim),박경훈(Kyung-Hoon Park),이제봉(Jea-Bong Lee),신진섭(Soon-Sung Hong),홍순성(Jin-Sup Shin),이규승(Kyu-Seung Lee),이정준(Jung-Joon Lee) 한국농약과학회 2008 농약과학회지 Vol.12 No.1
The purpose of the study was to determine the effects of isoprothiolane, diazinon, butachlor, dimethametryn and molinate in Selenastrum capriconutum, Scenedesmus subspicatus, Chlorella vulgaris and Nitzschia palea during an exposure period or 72 hours. The study was carried out in according with the GECD Guidelines for Testing of Chemicals No 201 Alga, Growth Inhibition Test. The toxicological responses of isoprothiolane to S. capriconutum, S. subspicatus, C. vulgaris and N. palea expressed as in individual ErC?? (Median Effective Concentration by growth rate) value, were 5.87, 9.91, 18.55 and 38.79 ㎎ L?¹, respectively. Diazinone to S. capriconutum, S. subspicatus, C. vulgaris and N. palea expressed as in individual ErC?? value, were 10.31, 11.44, >32 and 14.32 ㎎ L?¹, respectively. Butachlor to S. capriconutum, S. subspicatus, C. vulgaris and N. palea expressed as in individual ErC?? value, were 0.002, 0.019, 8.67 and 4.94 ㎎ L?¹, respectively. Dimethametryn to S. capriconutum, S. subspicatus, C. vulgaris and N. palea expressed as in individual EC?? value, were 0.0071, 0.011, 0.0065 and 0.009 ㎎ L?¹, respectively. Molinate to S. capriconutum, S. subspicatus, C. vulgaris and N. palea expressed as in individual ErC?? value, were 0.44, 1.26, 48.84 and 28.52 ㎎ L?¹, respectively. The sensitivities of five pesticides were different depending on freshwater alga in the order of S. capriconutum > S. subspicatus > C. vulgaris, N. palea. Highly significant correlation (r=0.9677) based on ErC??s were found between S. capriconutum and S. subspicatus.
류마티스 관절염 환자에서 Methotrexate와 관련된 간질성 폐렴
김지연 ( Ji Yeon Kim ),김완욱 ( Wan Uk Kim ),김성일 ( Sung Il Kim ),류완희 ( Wan Hee Yoo ),박성환 ( Sung Hwan Park ),홍연식 ( Yeon Sik Hong ),김석찬 ( Seok Chan Kim ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ),이연수 ( Youn So 대한류마티스학회 1998 대한류마티스학회지 Vol.5 No.1
The use of oral methotrexate in a low dose given once weekly has become the mainstay of therapy for active and sustained rheumatoid arthritis. Pneumonitis can be expected to occur in patients taking low doses of methotrexate for rheumatoid arthritis. The pathology suggests that methotrexate pneumonitis is a hypersensitivity reaction although arguments have been put forth that it is idiosyncratic. Treatment of presumed methotrexate pneumonitis, even while waiting for special stains, cultures, or tissue sections from bronchoscopic biopsy, should be glucocorticoids given intravenously or by mouth. Empirical antibiotic treatment can be used until infectious causes are ruled out. In recent years there has been an increase in the number of reports of pulmonary complications associated with low-dose methotrexate therapy for rheumatic diseases. Among these complications interstitial pneumonitis has been most often reported (more than 35 cases since the first report in 1983). We report a case of methotrexate-associated pulmonary complication in rheumatoid arthritis confirmed by trans-bronchoscopic lung biopsy, which resolved by treatment of corticosteroid therapy.
전신성 홍반성 루푸스에 병발한 Aspergillosis 2예
김현수 ( Hyun Su Kim ),홍연식 ( Yeon Sik Hong ),배상수 ( Sang Su Pae ),김완욱 ( Wan Uk Kim ),민준기 ( Jun Ki Min ),이상헌 ( Sang Heon Lee ),박성환 ( Seong Whan Park ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ) 대한류마티스학회 1999 대한류마티스학회지 Vol.6 No.3
Invasive infections with Aspergillus species may occur in patients with severe immune deficits and have been described rarely in systemic lupus erythematosus. We present two cases of pulmonary aspergillosis in steroid-treated systemic lupus erythematosus(SLE). Both patients had active SLE treated with high dose corticosteroids and prescribed with broad spectrum antibiotics. One patient had combined infection with pulmonary tuberculosis and the other present granulocytopenia. The diagnosis was delayed because symptoms and radiologic findings were confused with lupus pneumonitis and bacterial infections. This was similar to those reported previously. Diagnosis was confirmed by identification of the typical septated hyphae within tissue. We prescribed high dose amphotericin B to both patients. But one died with sepsis. Aspergillosis should be suspected in patients with active SLE who are immunocompromised and sustain concomitant bacterial infections. More aggressive diagnostic investigation and treatment may be needed to improve poor prognosis.
Sjogren 증후군 환자에서 발생한 재발성 다발성 연골염
이관형 ( Kwan Hyong Lee ),홍연식 ( Yeon Sik Hong ),강형주 ( Hyong Ju Kang ),김세희 ( Se Hee Kim ),김명철 ( Myoung Cheol Kim ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ),김기준 ( Ki Jun Kim ) 대한류마티스학회 2001 대한류마티스학회지 Vol.8 No.3
Relapsing polychondritis is a rare multisystem rheumatic disease, characterized by recurrent and potentially destructive inflammatory lesions of cartilaginous structures. All types of cartilage & other proteoglycan-rich structures may be involved, resulting in auricular chondritis, laryngotracheal chondritis, ocular symptoms, vasculitis, cardiac abnormalities, skin lesions and glomerulonephritis. The disease may be associated with another connective tissue and autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, Sjogren`s syndrome and systemic vasculitis. We experienced a 69-year-old female patient who had been previously diagnosed as Sjogren`s syndrome, presenting respiratory tract involvement, episcleritis, auricular chondritis and vestibular dysfunction.
신석준(Seok Joon Shin),김홍기(Hong Ki Kim),이정민(Jung Min Lee),민준기(Jun Ki Min),이상헌(Sang Heon Lee),홍연식(Yeon Sik Hong),안중현(Joong Hyun Ahn),조철수(Chul Soo Cho),송정섭(Jeong Sup Song),김호연(Ho Youn Kim) 대한내과학회 1998 대한내과학회지 Vol.54 No.6
Sarcoidosis is a multisystem granulomatous disorder of unknown etiology presenting with bilateral hilar lymphadenopathy, pulmonary, skin, and eye lesion. Sarcoidosis involving skeletal muscle is rare and occurs in two forms, nodular and myopathic, In the nodular variety, patients have single or multiple nodules in the skeletal muscles. Patients with the myopathic type have myalgia, muscle weakness, and atrophy. To our knowledge, this is the first case of sarcoidosis involving skeletal muscle in Korea. In this report, we describe a 40-year-oid man presenting with nodular type of muscular sarcoidosis and stage II pulmonary sarcoidosis. By this case, we emphasize the usefulness of magnetic resonance imaging in the diagnosis of nodular type of muscular sarcoidosis.