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홍순준,안태훈,심완주,박성미,최종일,박재석,임상엽,임도선,박창규,서홍석 대한심장학회 2008 Korean Circulation Journal Vol.38 No.5
Background and Objectives : Clodronate liposomes deplete phagocytic cels, thereby suppresing inflammation after vascular injury. We compared the efect of clodronate liposomes on macrophage depletion and neointimal formation in apolipoprotein E-deficient mice [ApoE (-) mice]. Materials and Methods : ApoE (-)to the clodronate liposomes group (Clodronate Group, n=7) and the vehicle liposomes group (Control Group, n=7). Clodronate (0.1 mL/10 g) was injected via the tail vein starting 2 days (d-2) before left common carotid artery injury. Results: The percentage of blod monocytes was subsequently decreased after clodronate injection (14.0± 7.4% at baseline, 6.8± 4.9% at 24 hours and 0.7± 0.3% at 1 wek after the clodronate liposome injection). The percentage of macrophages in the plaque area was significantly lower in the clodronate group at week 2 (32.0± 6.5 vs. 68.7±7.6%, respectively, p<0.05) and at wek 4 (37.3± 8.5 vs. 62.6± 9.4%, respectively, p<0.05). The interleukin (IL)-6 and tumor necrosis factor (TNF)-α concentrations were significantly decreased in the clodronate group at wek 4 (12.3± 2.5 vs. 22.9± 3.5 pg/mL, respectively, p<0.05 for IL-6 and 16.6± 2.2 vs. 43.6± 6.1 pg/mL, respectively, p<0.05 for TNF-α). The plaque volume was significantly greater in the control group at week 2 (0.345± 0.063 vs. 0.153± 0.053 mm2, respectively, p<0.05) and at week 4 (0.320± 0.027 vs. 0.167± 0.070 mm2, respectively, p<0.05). Conclusion : Intravenous administration of clodronate liposomes depleted monocytes and macrophages, and so this reduced the inflammatory markers and neointimal formation in ApoE (-) mice.
홍순준,김무현,안태훈,심완주,박성미,최종일,주형준,신승용,임상엽,임도선 대한심장학회 2007 Korean Circulation Journal Vol.37 No.11
Background and Objective: Coronary restenosis after drug-eluting stent (DES) implantation occurs more fre-quently in diabetic patients than in nondiabetic patients. We compared the parameters influencing the like-Subjects and Methods: Pat-ients who underwent DES implantation (619 patients with 917 lesions, 21 diabetics and 408 nondiabetics), folowed by 8 months coronary angiogram, were retrospectively identified using the percutaneous coronary intervention database and included in the present study [AH1]. Predictors of restenosis were identified by multivariate logistic regression analyses. Results: The baseline characteristics of the patients, such as sex, body mas index, hypertension, hyperlipidemia, and smoking status, were similar betwen the diabetic and nondiabetic patients. Restenosis (>50% of the diameter stenosis) occured in 32 of 408 (7.8%) nondiabetic patients and in 32 (15.2%) of 21 diabetic patients (p<0.001). The use of a paclitaxel-eluting stent (PES), a higher level of C-reactive protein (CRP), longer stent length, smaler reference diameter (RD) before DES implantation, smaller RD and minimal lumen diameter after DES implantation were comon predictors of restenosis in both the diabetic and nondiabetic patients after multivariate analyses. Curent smoking status [odds ratio (OR)= 3.213, 95% confidence interval (CI) = 0.004] and right coronary lesions (OR= 2.444, 95% CI 1.048 to 5.703, p=0.039) were predictors of restenosis in the diabetic patients, while higher body mas index (OR= 1.322, 95% CI 1.054 to 1.659, p=0.016) and A-type lesions (OR= 0.108, 95% CI 0.022 to 0.530, p= 0.06 ) were predictors of rest-enosis in the nondiabetic patients. Conclusion: The use of PESs and higher levels of CRP were associated with restenosis regardles of the presence of diabetes. Moreover, small baseline and post-PCI reference diameter and patients, even in the era of DES implantation
Decrease in Plasma Adiponectin Concentrations in Patients with Vasospastic Angina
홍순준,박창규,서홍석,나승운,김진원,오동주,권정아,이갑노,장양수,노영무 대한심장학회 2006 Korean Circulation Journal Vol.36 No.4
Background and Objectives:Plasma adiponectin, which decreases the progression of atherosclerosis and insulin resistance, as well as suppressing lipid accumulation in macrophages, is decreased in patients with acute myocardial infarction and unstable angina pectoris; however, the correlation between plasma adiponectin and vasospastic angina pectoris (VAP) remains to be verified. We compared the plasma adiponectin concentration between patients with VAP and other coronary artery diseases; moreover, we investigated the association between the plasma adiponectin concentration and VAP. Subjects and Methods:Following coronary angiography for the evaluation of chest pain, 395 subjects (180 women and 215 men) were divided into 4 groups: acute coronary syndrome (ACS)(n=117), VAP (n=94), stable angina pectoris (SAP)(n=108) and angiographically normal coronary artery (n=76). The acetylcholine provocation test was used to confirm VAP, and plasma adiponectin concentrations were measured in all participants. Results:The plasma adiponectin concentrations in patients with VAP and ACS were significantly lower than that of the normal coronary artery group (6.6±5.4 vs. 5.2±4.0 vs. 9.0±6.2 μg/mL, p<0.001, respectively). A multivariate analysis indicated that plasma adiponectin [odd ratio (OR) 0.744, 95% confidence interval (CI) 0.645 to 0.858, p=0.001], smoking (OR 2.054, 95% CI 1.027 to 4.106, p=0.042) and age (OR 0.966, 95% CI 0.935 to 0.997, p=0.031) were independently correlated in patients diagnosed with VAP. Conclusion:Our results suggest that a decreased plasma adiponectin concentration may be associated with VAP. (Korean Circulation J 2006;36:255-260)