Alloxan 당뇨병에 대한 인삼의 효과

홍성표(Seoung-Pyo Hong),임무현(Moo-Hyun Yim),주현규(Hyun-Kyu Joo) 한국생약학회 1976 생약학회지 Vol.7 No.2

This study was aimed to investigate the effects of Ginseng ethanol extract on Diabetes induced by alloxan in comparison with that of insulin. The blood sugar, blood urea nitrogen, glutamic oxaloacetic transaminase and cholesterol were measured by spectrophotometry. The results were obtained as follows. 1. Ethanol extract of Ginseng increased the blood sugar level in normal rats. 2. Ethanol extract of Ginseng restrained the increase of blood sugar in diabetes induced by alloxan. 3. Ethanol extract of Ginseng acted to oppose a rapid decrease of blood sugar by insulin. 4. Blood urea nitrogen, glutamic oxaloacetic transaminase and cholesterol level in blood were not affected by Ginseng.

인삼이 흰쥐의 체중에 미치는 영향

홍성표(Seoung-Pyo Hong),임무현(Moo-Hyun Yim),주현규(Hyun-Kyu Joo) 한국생약학회 1976 생약학회지 Vol.7 No.2

The effect of alcohol extract of Ginseng orally administered on the changes of the body weight of rats was investigated. The body weight of rats during feeding with 0.1% Ginseng extract added in the diet was measured for 2 months and compared with that of normal rats. The result obtained in the experiment indicated that the change of body weight of rats (140∼170g) was not affected by Ginseng.

경피내시경하 위루술후 Mycobacterium chelonae Subsp. abscessus 에 의한 창상감염 1 예

이상호(Sang Ho Lee),김구엽(Ku Yeoup Kim),홍성표(Seoung Pyo Hong),김명재(Myung Jae Kim),양문호(Mun Ho Yang),서진태(Jin Tae Seou) 대한내과학회 1997 대한내과학회지 Vol.53 No.6

Mycobacterium chelonae is a rapidly growing organism that has been found in water, soil, and dust. Although it can colonize healthy persons without sequelae, it can also cause skin and soft tissue infections, pulmonary infections and other sequelaes and rarely, disseminated disease in immunocompromised patients. But, infections due to rapidly growing mycobacteria are probably markedly underdiagnosed and these organisms are capable of causing a wide spectrum of clinical disease. We experienced a case of wound infection with M. chelonae after percutaneous endoscopic gastrostomy and report with review of literatures.

만성신부전 환자의 자율신경 기능장애

이상호(Sang Ho Lee),최수철(Soo chul choi),홍성표(Seoung Pyo Hong),이태원(Tae Won Lee),임천규(Chun Gyu Lim),김명재(Myung Jae Kim) 대한내과학회 1998 대한내과학회지 Vol.55 No.2

Objectives: Impaired autonomic function in patients with chronic renal failure has been well documented in a number of studies to assess the degree of cardiovascular autonomic dysfunction and to assess the relationship with plasma catecholamines. The purpose of the present study was to evaluate the prevalence of autonomic dysfunction and to determine the effect of autonomic dysfunction on the increment of plasma catecholamine, dialysis-induced hypotension and hypotension during chronic dialysis. Methods: We measured the degree of autonomic damage and the concentration of plasma catecholamines in 20 patients on maintenance hemadialysis, 12 predialysis patients with chronic renal failure and 20 normal controls using a standardized battery of five cardiovascular reflex tests, Results: 1) In normal controls, 70% of cases had a normal or early parasympathetic abnormalities however in patients with chronic renal failure, 45.2% of patients had severe abnormalities. The prevalence of autonomic dysfunction was 62.5% and there was significant correlation between sympathetic and parasympathetic score in patients with chronic renal failure. 2) Although overall autonomic function was not different in two chronic renal failure groups, the magnitude of heart rate response to Valsalva maneuver was increased and the magnitude of fall of blood pressure in response to standing-up was reduced in dialyzed patients compared with nondialyzed petients. 3) Patients with autonomic dysfunction was older and had higher postdialysis concentration of plasma norepinephrine than those with normal autonomic function. 4) In dialyzed patients, predialysis concentration of plasma norepinephrine at rest varied widely and was significantly related to the duration of dialysis. Postdialysis concentration of norepinephrine was significantly correlated with the degree of parasympathetic damage. 5) There were no significant differences in autonomic damage or plasma catecholamines whether dialysisinduced hypotension and hypotension in chronic hemodialysis or not. Conclusion: Disturbances of autonomic nerve system are common in chronic renal failure with distinct abnormalities of parasympathetic function and additional sympathetic dysfunction. Elevated plasma norepinephrine seems to be related to the compensatory response of sympathetic nerve system to parasympathetic damage. Impairment of autonomic function does not appear specifically related to dialysis-induced hypotension or hypotension in chronic dialysis.

말기신부전증 환자의 좌심실 비대에 대한 심초음파도 연구

이상호(Sang Ho Lee),유혜영(Hye Young Ryu),송민수(Min Su Song),강흥성(Hung Sun Kang),홍성표(Seoung Pyo Hong),이태원(Tae Won Lee),임천규(Chun Gyu Lim),김명재(Myung Jae Kim) 대한내과학회 1998 대한내과학회지 Vol.55 No.3

Objective: Left ventricular hypertrophy is common and major complication in patients with end stage renal disease(ESBD), but pathogenesis is not clear. We have used echocardiography to evaluate influential factors and contractile performance according to the geometry of left ventricle. Methods: We measured left ventricular mass, the extent of pericardial effusion and systolic function of left ventricle with M-mode and two dimensional echocardiography in 99 cases of ESRD from March 1993 to March 1996. Results: 1) Body surface area and systolic blood pressure was higher in men than those in women. But, there was no difference in LV mass index or systolic function between the sex. 2) Among the 99 patients with ESRD, 89 cases(90%) had increased ventricular mass and 10 cases had normal ventricular mass. In the left ventricular hypertrophy groups, 60 cases had concentric hypertrophy, 29 cases had eccentric hypertrophy. 3) In patients with normal ventricular mass, hypertension and pericardial effusion were less frequent than in those with left ventricular hypertrophy. In patients with concentric hypertrophy, systolic blood pressure and body surface area were increased and serum albumin was decreased as compared to patients with eccentric hypertrophy. In patients with eccentric hypertrophy, duration of dialysis was increased. But, the result of Logistic analysis showed that systolic blood pressure and serum albumin were reliable factors for the geometry of left ventricle. 4) In patients with eccentric hypertrophy, LV mass index was significantly correlated with the concentration of serum alkaline phosphatase and phosphate. But, in patients with concentric hypertrophy, any factors were not correlated with LV mass index. 5) Systolic performances such as ejection fraction and fractional shorter were decreased in patients with eccentric hypertrophy. 6) The pattern of left ventricular hypertrophy was not different among non-dialysis group, hemodialysis group and CAPD group. Conclusion: In patients with ESHD, left ventricular hypertrophy is a common complication and most common hypertrophic type is concentric hypertrophy. The geometry of left ventricular hypertrophy may be influenced by various factors such as systolic blood pressure and serum albumin concentration and influence on the systolic performance of left ventricle. urther study for the geometry of left ventricle and the prognosis may be necessary for the improvement of cardiovascular complications in patients with ESRD.

Buried Bumper Syndrome 1예

이상호,홍성표,박필원,김배영,원욱희,최욱선,임규성 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.5

Percutaneous endoscopic gastrostomy is used for long-term nutritional support and can be performed with relatively few complications. Among the major and minor complications, migration and erosion of the internal bumper into or through the abdominal wall, so called buried bumper syndrome has been described more recently. We describe a patient in whom internal bumper eroded into stomach wall and was completely covered by gastric epithelium 45 days after gastrostomy placement. The gastrostomy tube itself was patent, and the end still protruded into the lumen of the stomach. But, endoscopy was failed to remove the gastrostomy tube and surgical exploration was required in our case. We experienced a case of buried bumper syndrome after percutaneous endoscopic gastrostomy and report with a review of literatures.

과다체중이 지구성 운동중 대사작용 및 호흡순환계 반응에 미치는 영향

전종귀,박해근,홍성표 忠南大學校體育科學硏究所 1989 體育科學硏究誌 Vol.7 No.1

Six male physical education major students (2 volleyball players, 1 alpinist, and 3 non-athletes) were studied to determine the effect of excess body weight or fat on metabolic and cardiorespiratory responses to treadmill walking. The metabolic and cardiorespiratory responses to treadmill walking (speed : 90m/min) were measured in six subjects under each of four added-weight(AW) conditions : normal body weight and 5, 10, and 15% additional external weight, added to the trunk. AW was found to systematically and significantly increase HR, Systolic BP, VE, VO₂, VCO₂, But AW did not change RER, urine osmolality, Na+, and K+ concentrations. It was concluded that excess body weight or fat may lead to detrimental effect on cardiorespiratory responses during prolonged exercise.