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가미통성산(加味通聖散)이 자발성 고혈압 흰쥐에 미치는 영향
최은희,임대웅,정태산,안가영,천혜선,전상윤,홍석,Choi, Eun-Hee,Lim, Dae-Woong,Jung, Tae-San,An, Ga-Yong,Chun, Hea-Sun,Jeon, Sang-Yun,Hong, Seok 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.3
Objective : This study was examined to investigate the effect of Gamitongseong-san(GTS) extract on spontaneous hypertension. Methods : After administering GTS extract to SHR for 4 weeks, we measured anti-oxygen effects, weight of body, heart and kidney, blood pressure, heart rate, aldosterone, catecholamine, electrolyte, uric acid, and BUN. Results : 1. GTS increased 2,2-diphenyl-1-picrylhydrazyl(DPPH) scavenging activity and superoxide dismutase(SOD) similar activity depending on the concentration. 2. GTS significantly decreased heart weight in spontaneously hypertensive rat. 3. GTS significantly decreased blood pressure and heart rate in SHR. 4. GTS significantly decreased aldosterone. 5. GTS significantly decreased norepinephrine and epinephrine. 6. GTS significantly decreased $K^+$. 7. GTS significantly decreased BUN. Conclusions : These results suggest that GTS may be usefully applied for the treatment of hypertension.