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1, 2-dimethylhydrazine 투여로 유발된 백서 대장점막병변에 vitamin A(retinol)가 미치는 영향에 대한 형태학적 연구
홍기숙 梨花女子大學校 醫科大學 醫科學硏究所 1989 EMJ (Ewha medical journal) Vol.12 No.4
Induction of intestinal tumor by subcutaneous injection of 1, 2-dimethylhydrazine(DMH), 20 ㎎/㎏/week, during 20 weeks was studied in rats fed by vitamin A(retinol) 50㎍, 500㎍/day. Mucosal epithelial cell hyperplasia and mitosis in one crypt was not significantly inhibited by vitamin A administration(P>0.05). In electron microscopic findings, the cytoplasmic vacuoles were decreased in DMH+vitamin A-treated rats than DMH only. Dysplasia of the colonic mucosa in DMH+vitamin A-treated group were more slowly developed than DMH-treated rats. In DMH-treated rats the tumors were early detected after 14 weeks, but in DMH+vitamin A-treated groups were seen after 20 weeks. All these findings suggest that vitamin A can effectively prevent cytotoxicity of carcinogen in early phase, but can not prevent carcinogenesis in late phase.
1, 2- Dimethylhydrazine 투여후 백서 대장점막 변화에 대한 광학 및 전자현미경적 연구
홍기숙,한운섭,김옥경 梨花女子大學校 醫科大學 醫科學硏究所 1987 EMJ (Ewha medical journal) Vol.10 No.1
The fact that the administration of 1,2-dimethylhydrazine 2Hcl(DMH) to rats by weekly subcutaneous injections causes the development of epithelial tumors of the large intestine has been known. But the axact processes of of early morphologic changes of colonic lesion induced by DMH treatment in the rats have not been fully testified as yet. The objective of the dissertation research is to examine early morphologic changes of colonic lesion induced by DMH treatment in the rats. Total seventy cases including 14 control rats of Sprague Dawley male rats were analyzed by histopathologic changes. One is 20mg/kg/wk DMH treated rat group and the other is 40mg/kg/wk DMH treated rat group. DMH was injected s.c. at the start of each treatment weekly during 20 weeks, and the animals were killed at 1, 3, 5, 6, 7, 9, 12, 14, 17 or 20 weeks both in 20mg/kg/wk DMH treated group and in 40mg/kg/wk DMH treated group. The following results were obtained: Hyperplasia and mitosis of the crypt are presented in early phase of DMH treatment. Cellular dysplasia, carcinoma in situ, and invasive carcinoma are shown in later phase of DMH treatment. The same changes as the above are also identified in electron microscopic findings. The more doses of DMH are injected to rats, the more evident these findings are presented. The alkaline phosphatase activity in glandular epithelial cells are observed in cellular dysplasia and neoplastic changes. The alkaline phosphatase may be considered as tumor marker.
홍기숙,이순남,함정희 梨花女子大學校 醫科大學 醫科學硏究所 1993 EMJ (Ewha medical journal) Vol.16 No.4
Selective absence of serum IgA is the most commonly diagnosed form of human immnndefi-ciency disease, being reported in about one in 500-700 subjects in population surverys. Datailedclinical and laborattory studies of subjects with selective IgA deficiency generally reveal significantly increased incidence of sinopulmonary infection, gastrointestinal symptomatology, autoimmune disease and autoantibodies. Authors experienced selective IgA deficiency associated with an scleroderma in a 25 yearsold young woman. She had pulmonary tuberculosis, high IgE level, reactive rheumatoid factor,positive for antinuclear antibody, and no presence of anti-IgA antibody.
방광에 발생된 Malignant Mixed Mesodermal Tumor : 증례보고 및 문헌고찰 A Case Report and Literature Review
홍기숙,한운섭,김옥경 梨花女子大學校 醫科大學 醫科學硏究所 1981 EMJ (Ewha medical journal) Vol.4 No.3
A malignant mixed mesodermal tumor of the bladder from 70-year-old woman is presented. Malignant mixed mesodermal tumor is a designation applied to carcinosarcoma characterized by the presence of heterologous mesenchymal elements. The tumor tends to be large, bulky, intraluminal tumors that grows rapidly and infiltrates widely. The tumor occurs predominantly in elderly men, and aggresive surgical treatment is indicated because of the poor prognosis. Histologically this neoplasm was composed of epithelial components of transitional and squamous cell carcinoma, and mesnechymal components of fibrosarcoma, chondrosarcoma, and osteogenic sarcoma.