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Abruptio placentae로 因한 Hypofibrinogenemia를 招來한 患者의 麻經驗 1例報告
허탁 대한마취과학회 1977 Korean Journal of Anesthesiology Vol.10 No.3
Abruptio placentae with incoagulability of blood is a very serious problem in anesthesia management to prevent shock and renal failure. Here we experienced one typical patient who was discharged in healthy condition.
Effects of Cyclic Nucleotide-Gated Channels in Vestibular Nuclear Neurons
허탁,장수정,정한성,박종성 전남대학교 의과학연구소 2011 전남의대학술지 Vol.47 No.3
This study was designed to investigate the effects an 8-Br-cGMP on the neuronal activity of rat vestibular nuclear cells. Sprague-Dawley rats aged 14 to 16 days were decapitated under ether anesthesia. After treatment with pronase and thermolysin, the dissociated vestibular nuclear cells were transferred into a chamber on an inverted microscope. Spontaneous action potentials and potassium currents were recorded by standard patch-clamp techniques under current and voltage-clamp modes. Twelve vestibular nuclear cells revealed excitatory responses to 1-5 μM of 8-Br-cGMP, and 3 neurons did not respond to 8-Br-cGMP. Whole potassium currents of vestibular nuclear cells were decreased by 8-Br-cGMP (n=12). After calcium-dependent potassium currents were blocked by tetraethylammonium, the potassium currents were not decreased by 8-Br-cGMP. These experimental results suggest that 8-Br-cGMP changes the neuronal activity of vestibular nuclear cells by blocking the calcium-dependent potassium currents that underlie the afterhyperpolarization.