http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
알코올 상담 센터 환자를 대상으로 한 알코올 의존의 생물학적 표지자 비교 연구
변정현,이병철,함병주,정찬승,허미나,이정준,최인근,Byun, Jung-Hyun,Lee, Boung-Chul,Ham, Byung-Joo,Chung, Chan Seung,Hur, Mina,Lee, Jung-Joon,Choi, Ihn-Geun 대한생물정신의학회 2006 생물정신의학 Vol.13 No.4
Objectives : Biochemical markers can provide an objective evidence of heavy alcohol drinking. The purpose of this study was to compare and evaluate the usefulness of biological markers detecting alcohol dependence, such as mean corpuscular volume(MCV), gamma-glutamyl transferase(GGT), and carbohydrate-deficient transferrin(CDT) in the patients of an alcohol counseling center. Methods : This study was done with 64 patients with alcohol dependence and 36 healthy subjects. Relative values(%) of CDT were determined in their sera with turbidimetric immunoassay(Bio-Rad %CDT assay, Axis-Shield ASA, Oslo, Norway), and were compared with conventional markers of alcohol consumption, GGT and MCV. Results : Among the patients with alcohol dependence, 78.1% showed abnormal %CDT levels compared with GGT(61.9%) and MCV(20.7%). The areas under the receiver operating characteristic(ROC) curves(95% confidence interval) for %CDT, GGT, and MCV were 0.934(0.866-0.973), 0.871(0.789-0.930), and 0.575 (0.472-0.673), respectively. Conclusion : %CDT seems to be the most reliable biological marker for the detection and monitoring of alcohol consumption in the patients with alcohol dependence of the alcohol counseling center.
알코올 의존 환자에서 탄수화물결핍 트랜스페린과 신경성장인자의 변화
전찬민,박병양,변정현,이병철,함병주,허미나,최인근,Jeon, Chan-Min,Park, Boung-Yang,Byun, Jung-Hyun,Lee, Boung-Chul,Ham, Byung-Joo,Hur, Mina,Choi, Ihn-Geun 대한생물정신의학회 2007 생물정신의학 Vol.14 No.3
Objectives:Recent studies have raised the possibility that nerve growth factor(NGF) is abnormally regulated in the central nervous system(CNS) of animal models with alcohol dependence. The possible alteration of NGF by prolonged alcohol intake may play an important role in alcohol-induced neurotoxicity. Carbohydrate-deficient transferrin(CDT) is regarded as a reliable biological marker of alcohol dependence. The goal of this study was to estimate the changes of %CDT and serum NGF level according to the duration of alcohol abstinence, and to identify whether %CDT level is associated with the serum NGF level in the patients with alcohol dependence. Methods:The subjects were 24 patients with alcohol dependence. We used the Axis-Shield ASA to measure the %CDT level and the enzyme-linked immunosorbent assay(ELISA) to measure the serum NGF level. %CDT and NGF levels were measured immediately after the admission and at 2 weeks after the admission. Results:Decreased %CDT were observed during the period of 2 weeks after the admission. NGF level was not significantly different after 2 weeks. The NGF levels were not correlated with %CDT. The possibility of %CDT as a predictor of alcohol-induced neurotoxicity was not confirmed. Conclusion:Serum NGF levels is not a reliable indicator of abstinence state in the patients with alcohol dependence. Further studies are needed to evaluate the relation between two indicators in regard to hematological and neurological changes in alcohol dependence.
증례 : 혈액종양 ; 무도병을 주소로 내원한 진성적혈구증가증 1예
김선웅 ( Sun Woong Kim ),유형민 ( Hyung Min Yu ),이윤정 ( Yoon Jeong Lee ),김희진 ( Hee Jin Kim ),허미나 ( Mina Hur ),이홍기 ( Hong Ghi Lee ) 대한내과학회 2014 대한내과학회지 Vol.87 No.5
Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by erythrocytosis. Clinical symptoms can range in severity from headache and tinnitus to thrombohemorrhagic complications. Neurologic symptoms are common at the onset of polycythemia; however, chorea due to PV is a rare complication. We present the case of a 77-year-old female who was referred to our hospital because of choreic movement of the limbs, head and face. She was diagnosed with JAK2V617F mutation-positive PV. Her chorea was completely resolved by phlebotomy combined with hydroxyurea and aspirin. (Korean J Med 2014;87:619-624)
박수연 ( Su Youn Park ),유형민 ( Hyung Min Yu ),김지완 ( Ji Wan Kim ),안상희 ( Sang Hee An ),김욱연 ( Wook Youn Kim ),허미나 ( Mina Hur ),이홍기 ( Hong Gi Lee ) 대한내과학회 2014 대한내과학회지 Vol.86 No.6
이식 후 림프증식 질환은 이식 환자에서 면역 억제로 인하여 나타나는 치명적 부작용으로서 보통 Epstein-Barr 바이러스 (EBV) 감염에 따른 저항력 약화가 발생 원인으로 추정된다. 36세 남자가 혈관면역모세포 T세포림프종 치료를 위한 자가 조혈모세포이식 후 673일째 오한, 발열을 주소로 내원하여 다발성 림프절 비대가 발견되었다. 조직검사 및 면역화학염색으로 Reed-Sternberg 세포와 EBV를 확인하였으며 호지킨 림프종으로 진단되었다. 총 8주기의 ABVD 복합 항암화학요법을 시행하였으며 잔단 후 15개월이 경과한 현재 완전관해 상태를 유지하고 있다. 본 증례는 자가조혈모세포 이식 후 발생한 호지킨림프종으로 국내에서는 첫 보고 사례이다. Post-transplantation lymphoproliferative disorder (PTLD) is a serious complication that can develop after either solid organ or hematopoietic stem cell transplantation (HSCT). The incidence of Hodgkin`s lymphoma (HL) ranges from 0.5-1.0% of PTLD after HSCT without T-cell depletion. Here, we report a case of HL-PTLD that occurred after autologous peripheral blood stem cell transplantation for an angioimmunoblastic T-cell lymphoma (AITL). A 36-year-old patient developed fever and chills with multiple lymphadenopathies at day 673 after auto-HSCT for AITL. Three months after the transplant, the patient developed fever with elevated plasma Epstein-Barr virus (EBV)-PCR values. The excisional biopsy revealed HL at Ann Arbor stage IIIB. A total of 8 cycles of chemotherapy with ABVD please define were performed, and the patient has remained disease-free. To our knowledge, this is first case report of HL-PTLD after auto-PBSCT in Korea. (Korean J Med 2014;86:774-780)