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허광식,손현화,김동규,박찬국,김만우,김정용,기근홍 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1
Primary unruptured appendiceal mucocele is a rare disease. It is very difficult to diagnose preoperatively because of the rarity of classical symptoms and low incidence. Usually it is discovered incidentally during abdominal ultrasonography(US), computed tomography(CT), or appendectomy for acute appendicitis. If untreated, one type of mucoceles may rupture producing a potentially fatal entity known as pseudomyxoma peritonei, therefore preoperative diagnosis is very important. With the advent of colonoscopy, abdominal US and CT, it has been possible to preoperatively diagnose mucocele of appendix. We experienced a case of appendiceal mucocele in a 60 year-old woman who had symptoms of lower abdominal discomfort and right lower quadrant abdominal pain, and it was diagnosed preoperatively by colonoscopy, abdominal US and CT. So we present this case with review of literature.
위 평활근에서 비교감성 비콜린성 이완반응과 Substance P에 의한 조절
허광식 ( Gwang Sik Heo ),장성종 ( Sung Jong Chang ),박찬국 ( Chan Guk Park ),김만우 ( Man Woo Kim ),장인엽 ( In Youb Jang ),김진호 ( Jin Ho Kim ),신무경 ( Moo Kyoung Shin ),염철호 ( Cheol Ho Yeum ),윤평진 ( Pyung Jin Yoon ),전제열 대한소화기학회 2003 대한소화기학회지 Vol.41 No.5
Background/Aims: In a gastric fundic strip, electrical field stimulation (EFS) evokes TTX-sensitive biphasic responses, consisting firstly of cholinergic contraction followed by a transient relaxation. It is well known that nonadrenergic noncholinergic (NANC) inhibitory nerve mediates a transient relaxation. This study was performed to investigate the characterization of relaxation and its modulation by substance P. Methods: Using Guinea-pig gastric fundic smooth muscle tissues, we recorded mechanical contractions induced by EFS in the organ bath with platinum. Results: NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase, reduced EFS-induced relaxation and these effects were reversed by L-arginine, a precursor of nitric oxide (NO). Sodium nitroprusside, a NO-donor, suppressed the fundic basal tension. Cell permeable 8-bromo-cGMP inhibited noradrenaline-induced contraction. The application of substance P increased basal tension and EFS-induced contraction and relaxation. NK-1 receptor antagonist ([D-Pro9-(spiro--lactam)9,10-Trp11]-Substance P) inhibited substance P-induced effects. TEA and apamin, K+ channel blockers, increased basal tension and EFS-induced relaxation. Conclusions: These results indicate that NANC inhibitory responses are mainly mediated by NO in the guinea-pig fundus and the release of NO is modulated by substance P through NK-1 receptor and by prejunctional K+ channels. (Korean J Gastroenterol 2003;41:358-365)
유색차광망을 통한 광환경 변화가 꽃도라지의 생육에 미치는 영향
허은주,이영란,구대회,권오근,이광식 한국화훼산업육성협회 2007 화훼연구 Vol.15 No.3
유색차광망을 통한 광환경 변화가 꽃도라지 생육에 미치는 영향을 살펴 본 결과 광환경에 대한 반응은 품종에 따라 다르게 나타났다. 상대적으로 개화가 빠른 ‘Pink Fresh’는 청색과 적색 차광망에서 무차광과 흑 색 차광망에 비해 초장과 측지수가 증가하였으나, 개화 가 다소 느린 ‘Rose Pink‘은 청색과 적색 차광망에서 는 무차광과 비슷한 초장을 보였고 오히려 무차광에서 분지수가 크게 증가하였다. 꽃수는 광량이 적은 흑색 차광망에서 감소하였고, 개화시기는 광량이 많은 무차 광에 가장 빨라 광질보다는 광량의 영향이 큰 것 나 타났다. 안토시아닌 함량은 분홍색인 ‘Pink Fresh’ 품 종에서 무차광과 청색 차광망에서 가장 낮아 광량과 광질 모두 안토시아닌 함량에 영향을 미치는 것으로 나타났다. The effect of light quantity and quality on the growth of lisianthus (Eustoma grandiflorum) was evaluated using 30% colored shade nets. Two cultivars, ‘Pink Fresh’ and ‘Rose Pink’, showed different growth responses to colored shade nets. Plant height and axillary branches increased in ‘Pink Fresh’ grown under blue and red shade nets as compared to black or no shade nets. However, the axillary branches decreased under three shade nets against no shade nets in ‘Rose Pink’. Black shade nets, providing the greatest shade of 38%, reduced flower number and delayed flowering in both cultivars. Flowering also delayed as light quantity decreased. Anthocyanin content of ‘Pink Fresh’ was the lowest in the blue shade net and no shade treatments, and it seems that both light quality and quantity affected anthocyanin synthesis.
생쥐 대장 평활근에서 막전압-의존성 이온 전류에 대한 tamoxifen 효과
박찬국,허광식,장성종,김만우,윤영,박도영,양경철,신무경,차경훈,염철호,윤평진,전제열 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1
Background and Objectives : Tamoxifen is a widely used anticancer drug for breast cancer causing frequent gastrointestinal side effects. The change of gastrointestinal motility is associated with the alteration of activities of membrane ion channels. The ion channel is found to play an important role in regulating membrane potential and cell excitability. This study was performed to investigate the effects of tamoxifen on the membrane ionic currents in colonic myocytes. Materials and Methods : Single colonic myocytes were isolated by using a collganase from murine proximal colon. The membrane currents were recorded by using a whole-cell patch clamp method at room temperature. Results : Two types of voltage-dependent K+ currents (A-type and delayed rectifier K+ currents) were recorded. Tamoxifen inhibited both types of voltage-dependent K+ currents (10 μM). However, tamoxifen did not change the half-inactivation potential and the recovery time of voltage-dependent K+ currents. Chelerythrine, a protein kinase C inhibitor, and phorbol-12,13-dibutyrate, a protein kinase C activator, did not affect the voltage-dependent K+ currents Guanosine 5-O-2-thiodiphosphate (GDPβS, a G-protein inhibitor), also did not affect on tamoxifen-induced inhibition of voltage-dependent K+ currents. In audition, tamoxifen completely inhibited the voltage-dependent Ca²+ currents in whole-test ranges. Conclusion : These results suggest that tamoxifen inhibits the voltage-dependent membrane ionic currents in colonic smooth muscle cells, and that this action may be relevant to the gastrointestinal side effects
비가림 조건에서 시비에 대한 논담수 중 총질소 및 총인 농도 반응
정재운,최우정,윤광식,김한용,곽진협,임상선,장남익,허유정,Jung, Jae-Woon,Choi, Woo-Jung,Yoon, Kwang-Sik,Kim, Han-Yong,Kwak, Jin-Hyeob,Lim, Sang-Sun,Chang, Nam-Ik,Huh, Yu-Jeong 한국관개배수위원회 2007 한국관개배수논문집 Vol.14 No.1
Temporal changes in total nitrogen (T-N) and phosphorus (T-P) concentrations in paddy floodwater in response to fertilization under rain-shielding pot and small-scaled field conditions were investigated. On the basis of the changing patterns, suggestions for the use of fertilization factors, such as days after fertilization, in developing models for the estimation of T-N and T-P loads from paddy fields were made. Total N concentration was susceptible to fertilization, showing a peak concentration right after fertilization followed by a decreasing pattern with the elapse of days after fertilization. The decreasing pattern of T-N concentration followed the first- order kinetics, indicating that the models are likely to be an exponential equation using days after fertilization as an independent variable. Comparison between the pot and field experiments conducted with soils different in soil fertility revealed that indigenous soil N concentration significantly affected T-N concentration, and this suggests that soil N status can be used as the second variable for the models. Meanwhile, temporal changes in T-P concentration did not respond to P fertilization as sensitively as T-N. In combination with other published results, our study suggests that rainfall intensity and other factors associated with farming activities that are likely to cause disturbance of soil particles containing P may be used as possible variables for the models.