http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
pH-Sensitive Polymers for Drug Delivery
허강무,배유한,강한창,이영주 한국고분자학회 2012 Macromolecular Research Vol.20 No.3
Various pH-sensitive polymers have been developed for biomedical applications and recently attracted much attention for pH targeting nanomedicine. Recent development of pH-sensitive polymer systems that sharply respond to specific pH environment in solid tumors and cells and demonstrate modulated properties (e.g., triggered drug release at extratumoral pH, ligands or cell penetrating peptides exposure by shielding/deshielding mechanism or by pop-up mechanism, and endosomal pH targeting) have led significant progress in tumor targeting technology. These pH-sensitive polymer systems combined with nanotechnology could be utilized as an alternative strategy to traditional targeting systems to overcome major problems in current chemotherapy represented by non-specific tissue distribution of the drugs, tumor heterogeneity, and multidrug resistance (MDR) against anticancer drugs. This review highlights recent progress of pH-sensitive polymers with special emphasis on pH targeting nanomedicine.
허강무,이정정,심혜은,강선웅,권보선 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
Disc herniation is one of the most common intervertebrate disc (IVD) diseases. The use of injectable hydrogel formulations have been suggested as a promising strategy for the treatment of degenerative disc disease that can both restore the biomechanical function and reduce the low back pain. Here, a new thermo-sensitive injectable N-hexanoyl glycol chitosan (HGC) hydrogel was fabricated with tunable thermosensitivity and high stability. Various HGCs that show thermo-sensitive sol-gel transition properties were synthesized and their physicochemical properties were characterized by <sup>1</sup>H NMR, FT-IR and rheological measurements. HGC hydrogel was injected into the degenerated IVD ex vivo model and evaluated by macroscopic observation, micro-computed tomography examination and histological analysis. The defected IVD was fully filled with HGC hydrogel, which was stable even at 28 days. These results suggested that HGC hydrogel has great potential for percutaneous treatment of disc herniation.