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이봄비,함대현,서봉준,조세형,염미정,심인섭,이혜정 한국통합생물학회 2012 Animal cells and systems Vol.16 No.4
The purpose of this study was to examine whether Phellodendri Cortex extract (PCE) could improve learning and memory impairments caused by lipopolysaccharide (LPS)-induced inflammation in the rat brain. The effect of PCE on modulating pro-inflammatory mediators in the hippocampus and its underlying mechanism were investigated. Injection of LPS into the lateral ventricle caused acute regional inflammation and subsequent deficits in spatial learning ability in the rats. Daily administration of PCE (50, 100, and 200 mg/kg, i.p.) for 21 days markedly improved the LPS-induced learning and memory disabilities in the Morris water maze and passive avoidance test. PCE administration significantly decreased the expression of pro-inflammatory mediators such as tumor necrosis factor-a, interleukin-1b, and cyclooxygenase-2 mRNA in the hippocampus, as assessed by RT-PCR analysis and immunohistochemistry. Together, these findings suggest that PCE significantly attenuated LPS-induced spatial cognitive impairment through inhibiting the expression of pro-inflammatory mediators in the rat brain. These results suggested that PCE may be effective in preventing or slowing the development of neurological disorders, including Alzheimer’s disease, by improving cognitive and memory function because of its anti-inflammation activity in the brain.
효율적인 온라인 게임 서버를 위한 객체풀링 기법에 관한 연구
김혜영,함대현,김문성 한국게임학회 2009 한국게임학회 논문지 Vol.9 No.6
대부분의 온라인 게임서버 엔진에서의 Accept()사용한 Looping방식의 동적인 메모리 할당 방식의 사용은 다수의 클라이언트를 동시에 수용하고 진행해야하는 온라인 게임 상의 로그인 서버엔진에 많은 부하와 함께 병목현상을 유발하게 된다. 따라서 본 논문에서는 온라인상에서의 효율적인 게임서버를 위해 정적인 메모리 할당기법을 사용하여 메모리 단편화를 최소화하고, 클라이언트의 접속 시 세션연결 및 클라이언트 객체의 초기화를 위해 발생하는 부하를 최소화하기 위한 AcceptEx()를 사용한 풀링기법과 정적메모리를 생성하여 동적 할당처럼 포인터로 할당하는 메모리 풀링 기법을 합친 객체 풀링기법을 제안하고, 제안 기법을 적용한 게임엔진을 설계하여 구현한 후, 성능평가를 통해 제안한 기법의 효율성을 보였다. There is a request from the client, we almost apply dynamic memory allocating method using Accept() of looping method; thus, there could be process of connecting synchronously lots of client in most of On-line gaming server engine. However, this kind of method causes on-line gaming server which need to support and process the clients, longer loading and bottle necking. Therefore we propose the object pooling scheme to minimize the memory fragmentation and the load of the initialization to the client using an AcceptEx() and static allocating method for an efficient gaming server of the On-line in this paper. We design and implement the gaming server applying to our proposed scheme. Also, we show efficiency of our proposed scheme by performance analysis in this paper.
이봄비,함대현,서봉준,염미정,심인섭,이혜정 대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.3
We investigated the anxiolytic-like activity of α -asarone (AAS) from Acorus gramineus in anexperimental rat model of anxiety induced by repeated administration of the exogenous stress hormonecorticosterone (CORT). The putative anxiolytic effect of AAS was studied in behavioral tests of anxiety,such as the elevated plus maze (EPM) test and the hole-board test (HBT) in rats. For 21 consecutivedays, male rats received 50, 100, or 200 mg/kg AAS (i.p.) 30 min prior to a daily injection of CORT. Dysregulation of the HPA axis in response to the repeated CORT injections was confirmed bymeasuring serum levels of CORT and the expression of corticotrophin-releasing factor (CRF) in thehypothalamus. Daily AAS (200 mg/kg) administration increased open-arm exploration significantly inthe EPM test, and it increased the duration of head dipping activity in the HBT. It also blocked theincrease in tyrosine hydroxylase (TH) expression in the locus coeruleus (LC) and decreased mRNAexpression of brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, in the hippocampus. These results indicated that the administration of AAS prior to high-dose exogenous CORT significantlyimproved anxiety-like behaviors, which are associated with modification of the central noradrenergicsystem and with BDNF function in rats. The current finding may improve understanding of theneurobiological mechanisms responsible for changes in emotions induced by repeated administrationof high doses of CORT or by elevated levels of hormones associated with chronic stress. Thus, AASdid exhibit an anxiolytic-like effects in animal models of anxiety.
김승태,함대현,김건호,박종배,한동오,박희준,심인섭,박희명,김기현,최성훈,이혜정 경희대학교 융합한의과학연구소 2007 Oriental Pharmacy and Experimental Medicine Vol.7 No.4
Radix Paeoniae rubra (PR) has been widely used for recovering acute inflammation with swelling and pain in Far East Asian countries. In order to investigate the anti-arthritic effect of PR herbacupuncture, several behavioral parameters such as body weight, knee circumference, squeaking threshold, and weight distribution ratio were investigated in an adjuvant-induced mono-arthritis rat model. We performed PR herb-acupuncture on Zusanli (ST36) of the right hind-leg once every second day for a total of 6 times from the second day of initiating arthritis with adjuvant injection, while the control group was treated with saline in the same way. In the experimental group, body weight significantly increased, knee circumference and squeaking threshold significantly decreased indicating the reduction of edema, and both the pain and inflammatory swelling of the hind paws measured by incapacitance meter decreased. Conclusively, PR herb-acupuncture has more promising effect in alleviating arthritic pain and inflammation than saline-acupuncture in rat model, hence further clinical study is required.