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Metronomic oral paclitaxel shows anti-tumor effects in an orthotopic mouse model of ovarian cancer
한호섭,이기헌,이인호,이재호,Chang-Sung Whang,Yeong-Woo Jo,김태진 대한부인종양학회 2014 Journal of Gynecologic Oncology Vol.25 No.2
Objective: The purpose of this study was to compare the in vivo anti-tumor efficacy of a mucoadhesive, lipid-based, oral paclitaxel formulation (DHP107) with traditional, intraperitoneal (IP) paclitaxel using an orthotopic mouse model of chemotherapy-sensitive SKOV3ip1 ovarian cancer. Methods: To determine the optimal therapeutic dose of oral paclitaxel, DHP107 was administered per os to female athymic nude mice at 0, 25, or 50 mg/kg twice per week. Control mice received 100 μL saline once per week. IP injections of paclitaxel at 5 mg/kg once per week were used for comparison. To evaluate the potential therapeutic effect of metronomic DHP107 chemotherapy, mice received DHP107 50 mg/kg once per week per os, which was compared with 25 mg/kg twice per week and with vehicle-treated controls. Results: Low-dose DHP107 (25 mg/kg) twice per week was as effective as IP paclitaxel (5 mg/kg once a week) but high-dose DHP107 (50 mg/kg once per week) was less effective at inhibiting tumor growth in an orthotopic mouse model (88%, 82%, and 36% decrease in tumor weight, respectively). Mice that received 25 mg/kg DHP107 twice per week or 50 mg/kg DHP107 once per week per os had a significant decrease in tumor weight compared with vehicle-treated controls (p<0.01, both doses). Conclusion: Metronomic oral chemotherapy with DHP107 showed anti-tumor efficacy in vivo similar to IP paclitaxel in an orthotopic mouse model.
Effect of margin status on recurrence following conization in women with carcinoma in situ of cervix
한호섭,김순규,구유진,이인호,김태진,이기헌,심재욱,임경택 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
We conducted this study to evaluate the clinical significance of a positive cone margin in patients with carcinoma in situ (CIS) of cervix. We retrospectively analyzed the medical records of 228 patients with CIS of cervix treated by conization in 2011. We compared the pathologic and cytologic results according to the resection margin status of conization. Of 228 patients who were diagnosed as CIS of cervix at conization, 136 (59.6%) and 151 (66.2%) patients were diagnosed as CIS at PAP smear and punch biopsy before conization, respectively. Cold knife conization was conducted in 78.9% of patients, and the others underwent LEEP. Ninety six patients (42.1%) had margin involvement and the others were margin free at the conization specimens. PAP smear following conization showed that CINs were significantly more in the patients with positive cone margins (p=0.006), and 24.0% of them showed abnormal cytology. Of 28 patients who had positive cone margin and underwent following reconization or hysterectomy, 20 (71.4%) showed no residual CIN lesions. Margin status of conization did not mean the presence or absence of CIN, but rather the higher frequency of residual CIN in specimens of abnormal subsequent cytology. In view of this fact, it is suggested that the margin status of conization can be a valuable marker for clinical management of CIS of cervix.
골반 및 대동맥 주위 림프절 절제술을 포함한 자궁내막암 병기설정 수술에서 수술적 접근 방법 비교
한호섭 ( Ho Suap Hahn ),윤석근 ( Seok Geun Yoon ),김우철 ( Woo Chul Kim ),최홍준 ( Hong Jun Choi ),이인호 ( In Ho Lee ),권용순 ( Yong Soon Kwon ),김태진 ( Tae Jin Kim ),임경택 ( Kyung Taek Lim ),이기헌 ( Ki Heon Lee ),심재욱 ( Jae 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.9
Objective: To compare laparoscopic surgery with laparotomy in comprehensive surgical staging of endometrial cancer. Methods: We retrospectively analyzed the medical records of 272 patients with endometrial adenocarcinoma treated by staging operation including pelvic and paraaortic lymphadenectomy between January, 1996 and December, 2007. Results: There was no significant difference between the two groups in terms of age, body mass index, or histologic type, but in the laparotomy group, grade and surgical stage were significantly higher. All the patients, 182 in the laparotomy and 90 in the laparoscopy group, had lymphadenectomy, and the mean number of pelvic and paraaortic lymph nodes (LNs) obtained were 33.1±13.2 and 16.1±11.6 in the laparoscopy group, and 32.5±14.5 and 19.0±12.7 in the laparotomy group, respectively; these differences were not statistically significant. In the laparoscopy group, the operating time and postoperative hospital length of stay were shorter than in the laparotomy group, as were the pre- and post-operative hemoglobin changes. There were no significant differences between the two groups in terms of intra- or post-operative complications, but positive lymph nodal metastasis and conducting of postoperative adjuvant therapy were highter in the laparotomy group. The operative technique did not influence overall or disease-free survival after adjusting for several confounding factors. Conclusion: Laparoscopic-assisted surgical staging for endometrial cancer required a shorter operating time, shorter postoperative hospital stay, and lower blood loss compared to traditional laparotomy staging, and can be a good therapeutic option for staging operation including lymphadenectomy of endometrial cancer.
The adequacy of conization in the management of adenocarcinoma in situ of the uterine cervix(초)
한호섭 ( Ho Suap Hahn ),( Mi La Kim ),( Seok Geun Yoon ),( Woo Chul Kim ),( Hong Jun Choi ),( Sung Ran Hong ),( Hy Sook Kim ),( Yong Soon Kwon ),( In Ho Lee ),( Kyung Taek Lim ),( Ki Heon Lee ),( Jae Uk 대한산부인과학회 2009 대한산부인과학회 학술대회 Vol.95 No.-
Laparoscopic assisted vaginal hysterectomy vs. abdominal hysterectomy in endometrial cancer
한호섭 ( Ho Suap Hahn ),( Seok Geun Yoon ),( Jae Shik Hong ),( Yong Soon Kwon ),( In Ho Lee ),( Kyung Taek Lim ),( Ki Heon Lee ),( Jae Uk Shim ),( Jung Eun Mok ),( Tae Jin Kim ) 대한산부인과학회 2008 대한산부인과학회 학술대회 Vol.94 No.-
자궁내막 생검에서 비정형 자궁내막증식증 진단 시 향후 임상적 접근 방법
한호섭 ( Ho Suap Hahn ),윤석근 ( Seok Geun Yoon ),김우철 ( Woo Chul Kim ),최홍준 ( Hong Jun Choi ),이인호 ( In Ho Lee ),권용순 ( Yong Soon Kwon ),김태진 ( Tae Jin Kim ),임경택 ( Kyung Taek Lim ),이기헌 ( Ki Heon Lee ),심재욱 ( Jae 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.12
Objective: To evaluate the proper approach in women diagnosed with atypical endometrial hyperplasia (AEH) by endometrial biopsy. Methods: We retrospectively analyzed the medical records of 108 patients who underwent hysterectomies for AEH diagnosed by endometrial biopsy from 2000 to 2007. The results of the endometrial biopsies were graded on an ordinal scale and were compared with pathologic features obtained at the hysterectomy. Results: AEH was initially diagnosed by dilatation and curettage (87 cases) or endometrial biopsy with a Z-sampler (17 cases). The remaining four cases were diagnosed by hysteroscopic polypectomy. In patients preoperatively diagnosed with AEH by biopsy, hysterectomy specimens revealed a rate of simple or complex endometrial hyperplasia without atypia of 33.3% with AEH and normal endometrium found in 52.8 and 3.7% of specimens, respectively. The incidence of endometrial carcinoma was considerably high (11/108, 10.2%). All cases were confined to the endometrium and two of those were located at the adenomyosis without myometrial invasion. All patients with endometrial carcinoma displayed coexisting atypical complex hyperplasia following hysterectomy. Conclusion: Biopsy specimens showing AEH, particularly atypical complex hyperplasia, are associated with an increased risk of coexisting endometrial carcinoma. When considering management strategies for women with a biopsy diagnosis of AEH, clinicians should take into account the considerable rate of concurrent endometrial cancer and the discrepancy with pathologic diagnosis.
양성 자궁병변에 대한 세 가지 다른 자궁적출술 접근 방법
한호섭 ( Ho Suap Hahn ),최규홍 ( Kyu Hong Choi ),김주명 ( Joo Myung Kim ),이현주 ( Hyun Joo Lee ),최노미 ( No Mi Choi ),유원식 ( Won Sik Yoo ),김경연 ( Kyung Yeon Kim ),김남숙 ( Nam Sook Kim ),조수희 ( Soo Hee Jo ),홍준식 ( Jun Sh 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.5
Objective: To evaluate the rates and clinical outcomes between abdominal hysterectomy (AH), laparoscopic hysterectomy (LH) and vaginal hysterectomy (VH). Methods: Medical records of 236 patients who underwent hysterectomy (by one surgeon) for benign uterine pathology between march 2004 and april 2006 were reviewed. Primary outcome measure was the rate of each method of hysterectomy. Secondary outcome measures included perioperative and postoperative outcomes between groups. Results: The mean age, weight, height, body mass index, and parity in three groups showed no difference. In two hundred and twenty two cases of hysterectomies, the rate of AH was 13.5%, LH 34.2%, and VH 52.3%. Perioperative outcomes of AH, LH and VH were as follows : operative time (83.2±27.1 min, 94.2±25.2 min, and 50.8±15.5 min, respectively), change in hemoglobin (2.3±1.5 g/dL, 2.0±0.9 g/dL, and 1.3±1.1 g/dL, respectively), duration of urinary catheterization (2.0±0.2 days, 1.0±0.0 days, and 1.0±0.4 days, respectively), postoperative hospitalization (5.7±1.2 days, 4.7±0.9 days, and 4.3±1.0 days, respectively), uterine weight (733±665 g, 340±213 g, and 300±156 g, respectively). Uterine weight in the AH group was significantly heavier than in the LH and VH. The benefits of LH versus AH were shorter duration of urinary catheterization and postoperative hospitalization (p<0.05). The benefits of VH versus AH were shorter operative time, a smaller drop in hemoglobin, shorter duration of urinary catheterization and postoperative hospitalization (p<0.05). The benefits of VH versus LH were shorter operative time, a smaller drop in hemoglobin, and postoperative hospitalization (p<0.05). There were no differences in complications of AH, LH and VH (13.3%, 10.5%, and 9.5%, respectively p=0.825). Conclusions: Eighty six point five percent of hysterectomy can be done vaginal or laparoscopic approach. When there is a concerted effort to increase laparoscopic or vaginal hysterectomy, abdominal hysterectomy can decrease without increasing complication rate.
Multiplex PCR을 이용한 돌조개상과 (Bivalvia: Arcoidae) 이매패류 4종의 신속한 종 판별법 개발
김용휘,한호섭,윤봉한,박종연,백인국,방인철 한국패류학회 2021 The Korean Journal of Malacology Vol.37 No.4
A multiplex PCR primers (the species-specific primers) set using molecular biological methods targeting four species of ark shells (Anadara kagoshimensis, Tegillarca granosa, Anadara broughtonii and Cucullaea labiata) distributed in Korea were built, and a rapid and accurate species identification method was developed. The species-specific primer was designed within the nucleotide sequence of about 573 bp corresponding to the cytochrome c oxidase subunit 1 (co1) gene region of mitochondrial DNA, and considering the single nucleotide polymorphism (SNPs) representing inter-species variation excluding intra-species variation, it was designed with an interval of 80-100 bp for each species. As a result, it was confirmed that species-specific bands were formed in the order of A. kagoshimensis (160 bp), T. granosa (245 bp), A. broughtonii (351 bp), and C. labiata (471 bp). In addition, in order to measure the limit of multiplex PCR amplification according to the concentration of genomic DNA (gDNA) and the number of PCR amplification repetitions, 15 experimental groups were divided and measured. As a result, when the number of amplification repeats was 25 cycles, the concentration of gDNA was detected down to a minimum of 1 ng/μl. Therefore, the multiplex PCR primer set for four species of ark shells developed in this study is expected to be of great help in accurately and rapidly identifying species in the field, it is thought that economic damage and academic errors caused by misidentification can be prevented.