빈혈을 동반한 급성감염성 질환에서의 혈청 Ferritin치와 혈색소 변동에 대한 연구

韓始薰,崔平和,金舜謙 최신의학사 1989 最新醫學 Vol.32 No.5

윌슨병의 조기진단을 위한 선별검사(Screening)법 개발

한시훈,유은선,이수영,장영주,김순남,신하철,박선영,강주형 대한소아청소년과학회 2001 Clinical and Experimental Pediatrics (CEP) Vol.44 No.12

반월상 연골판 손상의 한의학적 치료에 대한 국내외 최신 연구 동향 분석

한시훈,오태영,오민석 대한한의학회 2022 대한한의학회지 Vol.43 No.1

Objectives: The purpose of this study was review the current clinical studies about the effect of Korean traditional medicine treatment for meniscus injury. Methods: Clinical studies on Korean traditional medicine treatment of meniscus injury were searched through 11 online databases. We analyzed the authors, publication year, country, study design, subjects, treatment methods, treatment effects, evaluation tools and adverse events of the selected studies. Results: 23 studies which included 9 randomized controlled trials, 8 case reports, 4 retrospective observational studies, 2 non-randomized controlled trials were selected through the databases. A total of 9 Korean traditional medicine treatments were used, among them, acupuncture treatment was the most used. The most commonly used outcome was effective rate. Conclusions: Through this study, we could confirm that Korean traditional medicine is an effective treatment for meniscus injury. It was suggested that various clinical studies on the effects of Korean traditional medicine for meniscus injury are needed and it is necessary to establish more scientific evidence through studies with a high level of evidence.

윌슨병의 조기진단을 위한 Screening법 개발

한시훈,이수영,장영주,신하철,박선영,유은선,Han, Si-Hun,Lee, Su-Yeong,Jang, Yeong-Ju,Sin, Ha-Cheol,Park, Seon-Yeong,Yu, Eun-Seon 대한유전성대사질환학회 2001 대한유전성대사질환학회지 Vol.1 No.1

동결견에 대한 뜸치료 효과의 체계적 문헌고찰

한시훈,이기언,변다영,김영익,김민균,민부기,임한빛,정연재,오민석 한방재활의학과학회 2019 한방재활의학과학회지 Vol.29 No.3

Objectives The purpose of this research is to evaluate the effectiveness of moxibustion theraphy for frozen shoulder through systematic review and meta-analysis. Methods The effect of moxibustion for frozen shoulder was constructed as a key question to search randomized controlled trials (RCTs) in 16 databases without type of publication restriction. Results A total of 790 studies were searched and 22 RCTs were finally selected through primary and secondary selection/exclusion process. In most of the evaluation indexes used in each study, moxibustion treatment for shoulder pain was statistically significant compared with other treatments. A meta-analysis of effective rate in 10 studies comparing moxibustion with acupuncture and acupuncture showed a statistically significant effect of moxibustion treatment. And there was a significant effect on the improvement of the shoulder mobility, but the effect size of shoulder pain was no significant effect for shoulder pain reduction. In addition in the result of meta-analysis of 4 studies' effective rate comparing moxibustion with electronic acupuncture, the effect of moxibustion was significantly higher than that of electronic acupuncture in frozen shoulder. Conclusions Moxibustion therapy was effective in symptoms in patients with frozen shoulder. However because of the high risk of bias in the quality of the included studies, the applicability of this study seems to be limited. It is thought that future randomized controlled trials will need to be designed and performed by reviewing ways to minimize bias. (J Korean Med Rehabil 2019;29(3):35-49)

구리대사의 분자생물학적 발전 : 윌슨병의 새로운 이해

한시훈 대한간학회 1998 Clinical and Molecular Hepatology(대한간학회지) Vol.4 No.3

교통사고로 발생한 경추 골절 환자에 대한 한방복합치료 효과: 증례보고

한시훈 ( Si-hoon Han ),이기언 ( Gi-eon Lee ),조경상 ( Kyeong-sang Jo ),변다영 ( Da-young Byun ),오민석 ( Min-seok Oh ) 대한한의학회 한방재활의학과학회 2018 한방재활의학과학회지 Vol.28 No.2

The objective of this study is to report the effects of complex Korean Medicine treatment for 2 patients who had cervical spine fracture casued by traffic accident. We used acupuncture, pharmacopuncture, moxibustion and herbal medicine to treat patients with cervical spine fracture. We observed the changes of pain by Numeric Rating Scale(NRS), Neck Disability Index(NDI) and EuroQol-5 Dimension Index(EQ-5D Index). After complex Korean Medicine treatment, we found that neck pain was reduced and quality of life were improved by NRS, NDI and EQ-5D Index. Complex Korean Medicine could be effective for patients with cervical spine fracture caused by traffic accident. (J Korean Med Rehabil 2018;28(2):113-120)

Ethylmalonic Encephalopathy

윤혜란,한시훈,안영민,신윤정,Yun, Hye-Ran,Han, Si-Hun,An, Yeong-Min,Sin, Yun-Jeong 대한유전성대사질환학회 2001 대한유전성대사질환학회지 Vol.1 No.1

아시아 및 한국에서 처음 발견된 3명의 소아 Ethylmalonic encephalopathy (EE) 환자들은 riboflavin을 이용한 치료법에 점진적인 호전을 보인 것으로 나타났다. Ethylmalonic aciduria가 3가지 효소-2-methyl-branched-chain acyl CoA dehydrogenase (2MBCAD), iso-valeryl CoA dehydrogenase (IVCAD), 그리고 short-chain acyl CoA dehydrogenase (SCAD) - 들의 부분적인 결함으로 생긴다는 가설하에 dehydrogenase (탈수효소)의 보조 효소인 riboflavin이 부분적으로 나마 치료 과정에서 어떤 역할을 수행하는지의 여부를 살펴보았다. 다음의 세 증례에서 riboflavin 혹은 coenzyme Q10을 병행하여 치료한 결과 인지 행동(cognitive behavior)과 만성 점액성 설사(chronic mucoid diarrhea)가 호전된 것으로 관찰되었다. 또한, 치료 후 운동 기능도 일부 호전되었다. EE의 질병 발생 기전이 현재까지 완전히 밝혀지지는 않았지만, 세 명의 EE 환자들의 치료경과를 관찰하여 위의 가설을 뒷받침 할 수 있었다.

신생아에서 여과지를 이용한 소변의 유기산분석 : 선천성 대사이상질환의 신생아 선별검사법 개발

이은하,한시훈 대한소아청소년과학회 2000 Clinical and Experimental Pediatrics (CEP) Vol.43 No.10

목 적 : 신생아 유전대사질환 선별검사는 질병을 조기에 발견함으로써 적절한 치료를 통하여 질병의 진행을 예방할 수 있고, 조기에 유전상담의 기회를 제공하여 준다. 현재의 신생아 선별검사는 주로 아미노산 대사이상에 대하여 시행되고 있으며, 유기산 질환에 대하여는 검사방법의 어려움과 경제적인 문제 때문에 시행되고 있지 않다. 본 연구는 여과지를 이용한 유기산 분석 방법을 개발하여 다양한 유기산, 지방산 대사질환 및 신경아세포종의 선별검사에 이용하고자 본 연구를 수행하였다. 방 법 : 단풍당뇨증, 메칠말로닌산혈증, 글루타릭산뇨증, medium-chain acyl-CoA dehydrogenase deficiency(MCAD), vitamin responsive disorders(B12, biotin, B2) 등과 같은 유기산 대사질환 및 신경아세포종을 선별하기 위한 standard marker를 선정하여 여과지에 묻힌 후 소변에서의 유기산을 분석하는 방법과 동일하게 추출, 분석하였고, 이들의 extraction efficiency와 안정성을 비교하여 유기산 질환의 선별 marker로서의 적합성을 조사하였으며, 정상 신생아와 유기산대사질환 환자의 소변을 동일한 방법으로 추출 분석, 비교하여 검사의 유용성을 확인하였다. 결 과 : Standard marker마다 차이는 있으나 건조된 여과지로부터의 유기산 추출 efficiency는 43.2- 136.5%로 다양하게 관찰되었으며, 환자군에서의 유기산 분석은 여과지에서 추출된 유기산분석으로도 특징적인 이상소견을 보여 충분히 진단이 가능하였다. Purpose : Neonatal screening for inherited metabolic disease is aimed at identifying affected infants early, thus permitting medical intervention to prevent or minimize the effect of the disease. However, organic aciduria, most of which causes severe disease and mental retardation, is not yet screened routinely because of the difficulty of tests, sample collection, and expenditure of time and financial resources. This study was designed to develop a screening method for the detection of multiple organic aciduria and neuroblastoma, using dried urine filter paper. Methods : The standard markers used for screening of organic aciduria were placed on the filter paper and analysed with the modified organic acid analysis method. The extraction efficiency and stability of standard markers were tested for the purpose of adequacy as screening markers, and the method described herein was evaluated by analyzing filter paper samples obtained from both normal newborns and patients with known organic aciduria. Results : The standard markers in the filter paper left in the room temperature over a period of 5 days were still stable without significant degradation. The level of specific organic acids obtained from known organic aciduria patients were easily detectable-enough to make the diagnosis. Conclusion : The filter papers soaked with urines obtained from newborns or patients with suspicious metabolic diseases are adequate for screening of organic acidurias and neuroblastoma. Sample delivery to the laboratory can be handled more easily with this method and even newborn screening could be applied in the future. (

Metabolic evaluation of children with global developmental delay

은소희,한시훈 대한소아청소년과학회 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.4

Global developmental delay (GDD) is a relatively common early-onset chronic neurological condition,which may have prenatal, perinatal, postnatal, or undetermined causes. Family history, physical andneurological examinations, and detailed history of environmental risk factors might suggest a specificdisease. However, diagnostic laboratory tests, brain imaging, and other evidence-based evaluationsare necessary in most cases to elucidate the causes. Diagnosis of GDD has recently improved becauseof remarkable advances in genetic technology, but this is an exhaustive and expensive evaluation thatmay not lead to therapeutic benefits in the majority of GDD patients. Inborn metabolic errors are one ofthe main targets for the treatment of GDD, although only a small proportion of GDD patients have thistype of error. Nevertheless, diagnosis is often challenging because the phenotypes of many genetic ormetabolic diseases often overlap, and their clinical spectra are much broader than currently known. Appropriate and cost-effective strategies including up-to-date information for the early identification ofthe “treatable” causes of GDD are needed for the development of well-timed therapeutic applicationswith the potential to improve neurodevelopmental outcomes.