勤勞 및 非行靑少年의 精神病理學的 硏究

韓善浩 순천향의과대학 1979 Journal of Soonchunhyang Medical Science Vol.2 No.2

In this study, it was aimed to reveal the psychopathological characteristics of the working adolescents and the juvenile delinpuents through the MMPI test. The subjects of the study were 203 male delinquents and 98 female delinquents, 109 malemale working adolescents and 90 female working adolescents. MMPI test was hiven to all 500 adolescents. The results were as follows: 1. F, Pa, Pt, and si scale were the high scores in the working adolescents and the delinquents compared with the normal akolescents. Between the working akolescents and the delinquents, the scores in these scales were higher for the delinquents than for the working akolescents, especially the Sc score. 2. In the delinquency, the delinquency sxale and the psychopathological scale, (critical itens), the scores for the delinquents were higher, and the scores for the working akolescents were also suggestive that the working group may have more problens than the normal adolescents. 3. fifty sevenpoint six percentage of the male delinquents and 29.4% of the male working adolescents were expected doing misdemeanour and for the female, 68.4% of the delinquents and 30.0% of the working group were expected doing so. 4. For the males, there is no difference in the frequency ratio of the psychopathological seriousness for the non expected delinquency group and the expected delinquency group respectively. But for the females, the psychopathological seriousness were the high scores for the non expected delinquency group. 5. from the previous results, it could be surmised that the working akolescents may have the delinquency and the psychopathological seriousness and that for the delinquents, the delinquency is remarkable at first but the psychopathological seriousness is a more important factor of their misdemeanour. Especially for the females, their psychopathological problems effected their misdeeds more than for the males.

핵사찰 환경시료의 우라늄 미세입자 분석을 위한 Laser ablation/ICP-MS 이용 타당성 검토

한선호,하영경,표형열,전영신,박용준 한국방사성폐기물학회 2004 한국방사성폐기물학회 학술논문요약집 Vol.2 No.2

Diverse Molecular Targets for Therapeutic Strategies in Alzheimer’s Disease

한선호,묵인희 대한의학회 2014 Journal of Korean medical science Vol.29 No.7

Alzheimer’s disease (AD) is the most common form of dementia caused byneurodegenerative process and is tightly related to amyloid β (Aβ) and neurofibrillarytangles. The lack of early diagnostic biomarker and therapeutic remedy hinders theprevention of increasing population of AD patients every year. In spite of accumulatedscientific information, numerous clinical trials for candidate drug targets have failed to bepreceded into therapeutic development, therefore, AD-related sufferers including patientsand caregivers, are desperate to seek the solution. Also, effective AD intervention isdesperately needed to reduce AD-related societal threats to public health. In this review,we summarize various drug targets and strategies in recent preclinical studies and clinicaltrials for AD therapy: Allopathic treatment, immunotherapy, Aβ production/aggregationmodulator, tau-targeting therapy and metabolic targeting. Some has already failed in theirclinical trials and the others are still in various stages of investigations, both of which giveus valuable information for future research in AD therapeutic development.

RAGE: The Beneficial and Deleterious Effects by Diverse Mechanisms of Actions

한선호,Yoon Hee Kim,묵인희 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.2

Receptor for advanced glycation endproducts (RAGE) is a transmembrane protein that belongs to the immunoglobulin superfamily. RAGE is expressed ubiquitously-high in lung and moderate to low in a wide range of cells-in a tightly regulated manner at various stages of development. RAGE is a pattern recognition receptor that binds to multiple ligands, including amphoterin, members of the S100/calgranulin family, the integrin Mac-1, and amyloid β-peptide (Aβ). RAGE-ligand engagement effects the activation of diverse cascades that initiate and stimulate chronic stress pathways and repair, depending on the ligand, environment, and developmental stage. Further, RAGE-ligand interaction and the consequent upregulation of RAGE through a positive feedback loop are often associated with various diseases, including vascular disease, diabetes, cancer, and neurodegenerative disease. It is unknown how RAGE mediates these events, but such phenomena appear to be linked to the inflammatory response. In this review, we summarize the findings on RAGE from published reports and ongoing studies. Also, the implication of RAGE in Alzheimer disease, the most common neurodegenerative disease in the elderly population, will be discussed, with a focus on Aβ-RAGE interactions with regard to signaling pathways and their impact on cellular activity.

Laser Ablation에 의한 고방사성시편의 미세영역 시료채취 장치개발

한선호,하영경,한기철,박양순,지광용,김원호,Han Sun Ho,Ha Yeong Keong,Han Ki Chul,Park Yang Soon,Jee Kwang Yong,Kim Won Ho 한국방사성폐기물학회 2005 방사성폐기물학회지 Vol.3 No.1

Shielded laser ablation system composed of laser system, image analyser, XYZ translator with motion controller, ablation chamber, manipulator and various optics was designed. Nd:YAG laser which can be tunable from 1064 nm to 266 m was selected as light source. CCD camera(< $\pm$200) was chosen to analyze a crater less than 50 un in diameter. XYZ translator was composed of three linear stage which can travel 50 w with a minimum movement of 1 um and motion controller. Before the performance test, each part of system was optically aligned. To perform the ablation test, the specimen was ablated by 50 um interval and observed by image analyser The shape of crater was almost round, indicating laser beam has homogeneous energy distribution. The resolution and magnification of image system were compatible with the design.

정신질환자의 사회복귀

이승부,김동희,한선호 순천향대학교 1992 논문집 Vol.14 No.4

정신질환자의 사회복귀는 모든 사회복귀의학의 중요한 구성부분이며 그 중요성은 수용된 장애자의 40%이상이 모두 정신병과 연관되며 또한 정신병의 예방, 치료, 기능훈련은 단지 임상치료로만 해결할 수 없다는 사실에 있다. 사회복귀는 임상치료의 계속이고 점점 많은 사람들의 관심을 불러일으키고 있어 지속적으로 발전되고 있다. 연변사회정신병원(이하 병원이라고 줄임)은 1956년에 개원되어 현재 500베드를 구비한 민정계통에서 관할하는 자선의료사업단체이며 주로 연변지구 208만 인구중 의지할 곳 없고, 집이 없고, 경제적 능력이 없는 민정대상인 정신병환자들의 치료를 맡아보며 치료방법들로는 약물, 심리, 작업, 작문요법 즉 4결합요법을 위주로 하고 사회복귀사업을 폭넓게 추진하고 있으며 개방관리를 실시하고 있다. 본 논문은 주로 병원의 사회복귀병원인 분원의 정신질환자의 사회복귀사업에 관하여 소개, 토론, 연구하려 한다. 연변사회정신병원의 이승부 원장과 순천향대학병원의 한선호는 1990년 7월 30일부터 8월 17일까지 이 분원에 관하여 논문을 만들 것을 토의하였고 초안을 받고 중국과 한국에서 사용되는 한국어의 심한 차이로서 이해가 안되는 부분을 열심히 수정하면서도 뜻만 통한다면 되도록이면 원문에 충실하려고 노력하였기에 공저로써 발표한다. As a part of important problems in psychiatric area, the rehabilitation of psychiatric patients had been considered in many psychiatrists. The authous, thus, introduced rehabilitative programs in Yeonbyeon Social Psychiatric Hospital, China.

老人期의 우울증

韓善浩 藥業新聞社 1987 (月刊) 醫藥情報 Vol.1987 No.1

精神分裂症 臨床型의 特徵 및 그症狀에 對한 硏究

韓善浩 고려대학교 의과대학 1972 고려대 의대 잡지 Vol.9 No.1

In this clinical study, it was intended to asses the distribution of subtypes and their educational backgrounds, occupational histories, family histories, marital statuses, premorbid personalities, precipitating factors, ages of onset and symptomatology. The 242 cases of the schizophrenics were classified into 6 subtypes, which were 21 cases of simple type, 3 cases of hebephrenic type, 13 cases of catatonic type, 116 cases of paranoid type, 82 cases of latent type and 7 cases of schizoaffective type. The results were as follows: 1. Among the classified subtypes, the paranoid type and the latent type were most frequently observed in this order and the paranoid schizophrenics occupied frequently observed in this order and the paranoid schizophrenics occupied 47.9% of all and the latent schizophrenics occupied 33.9% of all. 2. As to the mean ages of each subtypes, the paranoid and the latent were eldest: the paranoid was 29.6 years old and the latent were 34.1 years old. The simple and the hebephrenic were youngest: the simple was 19.9 years old and the hebephrenic were 20.3 years old. 3. Educational background of each subtype revealed that the schizoaffective schizophrenics showed highest educational level of all. 4. As to the occupational histories, the jobless schizophrenics occupied the highest rate of 37.2%. 5. Family histories revealed that 35.9% of all schizophrenics had in their families some kinds of neurotic and psychotic patients. Among them 23.1% of schizophrenics had neurotic patients and 12.8% of schizophrenics had psychotic patients in their families. According to each subtype, the paranoid type with neurotic and psychotic diseases in their family occupied 35.4% and the latent type occupied 39.0%. In the paranoid type, the patients with psychotic disease in their family occupied 21.6%, on the other hand in the latent type, the patients with neurotic diseases in their family occupied 31.7%. 6. As to the premorbid personality, schizoid personality and paranoid personality were more frequent ones in general. According to each subtypes, the simple type and the catatonic type had significantly higher frequency of schizoid personality and the paranoid type had the higher frequency of paranoid personality and the latent type had the higher frequency of asthenic personality than the other types. The schizoaffective type almost exclusively had schizoid and paranoid personality. 7. In all schizophrenics, the most frequent symptoms were inappropriateness, emotional dullness, anxiety and fearfulness, decreased activity and incoherence. According to each subtypes, the character istic symptoms were as follows, the simple type had inappropriateness, emotional dullness. The catatonic type had negativism and blocking. The paranoid type had increased activity, auditory hallucination, delusion, incoherence and circumstantiality. Among the characteristic symptoms of paranoid type, the delusion were elicited from all of the paranoid schizophrenics. The latent type had inappropriateness, emotional dullness, anxiety and fearfulness, depressed mood, decreased activity, hypochondriasis and obsession.

통원수술부에 관한 건축계획적 연구

한선호,김광문 한국병원건축학회 1996 의료·복지 건축 Vol.1 No.2

As surgical technologies advanced, ambulatory surgery was proposed for reduction hospital stay and patient-oriented health care delivery system. And in recent years, ambulatory surgery is also introduced in this country as medical demands expands. This study aims to represent the standards for architectural planning of the ambulatory surgery center in general hospital according to domestic situation. For this. the present condition and space pro-grams of 5 general hospitals were investigated and analyzed. This study also aims to represent the unit area proposal of each departmental operation room and the methodology for deciding the number of the operation threatres in Ambulatory Surgery Center

Feasibility study for measurement of sulfur isotope ratio by MC-ICPMS with desolvation system

한선호,송규석,( Zsolt Varga ),( Judit Krajko ),( Klaus Mayer ) 한국환경분석학회 2013 제1회 한국분석기술단체 총 연합 합동 심포지엄 Vol.0 No.-