1형신경섬유종증 환자에서 보인 특발비후경수막염

한상원,민선기,박경미,김병섭 대한신경과학회 2022 대한신경과학회지 Vol.40 No.2

Squeeze Casting 에 의한 SiC 입자강화 Al 합금기 복합재료의 마멸 특성

한상원,우기도,김석원 대한금속재료학회(대한금속학회) 1996 대한금속·재료학회지 Vol.34 No.1

This study was aimed to investigate influence of microstructure, abrasive heat affected zone(AHAZ), primary silicon and eutectic silicon on abrasive characteristics of AC8A/SiC_p composite fabricated by the squeeze casting under various conditions. The abrasive characteristics was improved by addition of Mg and Ca elements because of improvement of SiC_p wettability and hardness in matrix. It is general theory that abrasive amount is decreased with increase of squeezing pressure. In this study, however, as squeezing pressure applies over a certain limit value(220MPa), the abrasive resistance under the condition of the high abrasive speed(3.67 ㎧) is not increased with increase of squeezing pressure. This is due to the crack by the generation of abrasive heat and fatigue below abrasive surface under the condition of high abrasive speed(3.67 ㎧). In abrasive heat affected zones of AC8A and AC8A/SiC_p composite fabricated by same squeezing pressure(220MPa), eutectic Si of directly below abrasive surface is finer than that of matrix, and abrasive heat affected zone of AC8A/SiC_p composite is thinner than that of AC8A. These reasons are that abrasive heat makes α dendrite and eutectic Si fine in AC8A/SiC_p composite. Therefore, the hardness of heat affected zone of directly below abrasive surface was increased sharply owing to abrasive heat.

$0.18{\mu}m$ CMOS 저 잡음 LDO 레귤레이터

한상원,김종식,원광호,신현철,Han, Sang-Won,Kim, Jong-Sik,Won, Kwang-Ho,Shin, Hyun-Chol 대한전자공학회 2009 電子工學會論文誌-SD (Semiconductor and devices) Vol.46 No.6

본 논문은 CMOS RFIC 단일 칩을 위한 Bandgap Voltage Reference와 이를 포함한 저 잡음 Low Dropout (LDO) Regulator 회로에 관한 것이다. 저 잡음을 위해 Bandgap Voltage Reference에 사용된 BJT 다이오드의 유효면적을 증가시켜야 함을 LDO의 잡음해석을 통해 나타내었다. 이를 위해 다이오드를 직렬 연결하여 실리콘의 실제면적은 최소화 하면서 다이오드의 유효면적을 증가시키는 방법을 적용하였고, 이를 통해 LDO의 출력잡음을 줄일 수 있음을 확인하였다. $0.18{\mu}m$ CMOS 공정으로 제작된 LDO는 입력전압이 2.2 V 에서 5 V 일때 1.8 V의 출력전압에서 최대 90 mA의 전류를 내보낼 수 있다. 측정 결과 Line regulation은 0.04%/V 이고 Load regulation은 0.45%를 얻었으며 출력 잡음 레벨은 100 Hz와 1 kHz offset에서 각각 479 nV/$^\surd{Hz}$와 186 nV/$^\surd{Hz}$의 우수한 성능을 얻었다. This paper presents a low-noise low-dropout linear regulator that is suitable for on-chip integration with RF transceiver ICs. In the bandgap reference, a stacked diode structure is adopted for saving silicon area as well as maintaining low output noise characteristic. Theoretical analysis for supporting the approach is also described. The linear regulator is fabricated in $0.18{\mu}m$ CMOS process. It operates with an input voltage range of 2.2 V - 5 V and provide the output voltage of 1.8 V and the output current up to 90 mA. The measured line and load regulation is 0.04%/V and 0.46%, respectively. The output noise voltage is measured to be 479 nV/$^\surd{Hz}$ and 186 nV/$^\surd{Hz}$ from 100 Hz and 1 kHz offset, respectively.

제조물책임(製造物責任)의 일반문제(一般問題)와 비교법적(比較法的) 고찰(考察)

韓相元 경희법학연구소 1996 경희법학 Vol.31 No.-

소아의 과민성방광

한상원 메디메디아코리아(주) 2004 유로트렌드 Vol.9 No.1

수술전 심전도의 가치

한상원,최석구,전영빈,이윤우,유원상 인제대학교 1990 仁濟醫學 Vol.11 No.4

수술전 심전도의 가치를 평가하기 위해 500례의 심전도들을 판독하고 심전도상 이상 소견을 보인 예들을 추적하였다. 176례들(35%)이 이상 소견을 보였으나 심근경색으로 판독된 5례들(1%)에서만 추가 검사를 실시하였고, 그 결과 4례(0.8%)에서 수술이 연기되었다. To evaluate the value of pre-operative electrocardiogram which has been taken nearly as a routine test, 500 pre-operative electrocardiogram were reviewed and consequent measures on the basis of abnormal electrocardiogram were investigated. 1.176 ECG's (35%) showed abnormal findings, but more than half of them were only minor changes. 2.20 cases (4%) wore referred to the cardiology section or the department of anesthesiology. 3.5 cases (1%) underwent further evaluations. such as serial ECG tracings, echocardiography, cardiac scan, measurement of cardiac enzymes. cardiac catheterization or coronary arteriography. 4.All above 5 cases showed findings of myocardial infarction. 5.Operation was deferred in 4 cases (0.8%).

멘붕의 시대에도 봄은 오는가

한상원 한국노동조합총연맹 2013 월간 한국노총 Vol.489 No.-

녹용(鹿茸) 약침(藥鍼)이 난소적출(卵巢摘出)로 유발(誘發)된 백서(白鼠)의 골다공증(骨多孔症)에 미치는 영향(影響)

한상원,이윤호,김창환,Han, Sang-Won,Lee, Yun-Ho,Kim, Chang-Hwan 대한약침학회 2000 Journal of pharmacopuncture Vol.3 No.1

In order to investigate the effect of the Cervi Pantotricuhum Cornu Herb-acupuncture treated on Shinsu($BL_{23}$) and Taejo($BL_{11}$) loci on the estrogen-deficiency osteoporosis induced by ovariectomy in rats, serum osteocalcin estradiol progesterone follicular stimulating hormone(FSH) calcium(Ca) and phosphorous(P) levels were monitored. The results were as follows : 1. Serum osteocalcin levels were significantly (p<0.01, p<0.05) increased in the Cervi Pantotricuhum Cornu Herb-acupuncture treated on Shinsu and Taejo group compared with control group. 2. Serum estradiol levels were increased In the Cervi Pantotricuhum Cornu Herb-acupuncture treated on Shinsu and Taejo group compared with control group, but Taejo group did not show significant value. 3. Serum progesterone levels were significantly(p<0.01) increased in the Cervi Pantotricuhum Cornu Herb-acupuncture treated on Shinsu and Taejo group compared with control group. 4. Serum FSH levels were significantly(p<0.01, p<0.05) decreased in the Cervi Pantotricuhum Cornu Herb-acupuncture treated on Shinsu and Taejo group compared with control group. 5. Serum Ca levels were significantly(p<0.01) increased in the Cervi Pantotricuhum Cornu Herb-acupuncture treated on Shinsu group compared with control group, but Taejo group did not show significant value. 6. Serum P levels were significantly(p<0.01, p<0.05) decreased in the Cervi Pantotricuhum Cornu Herb-acupuncture treated on Shinsu and Taejo group compared with control group. According to these results, the Cervi Pantotricuhum Cornu Herb-acupuncture treated on Shinsu and Taejo loci have favorable effect on treatment and prevention of osteoporosis induced by ovariectomy in rats.

일측 폐색성 및 역류성 수신증에서 술전 상대적 신기능의 의미

한상원,강선중,권민중,김대중,최승강,이택,Han Sang-Won,Kang Seon-Jung,Kwon Min-Jung,Kim Dae-Joong,Choi Seung-Kang,Lee Tack 대한소아신장학회 1999 Childhood kidney diseases Vol.3 No.2

목적 : 신생아 시기에 일측성 수신증의 자연경과는 여러 요인들에 의해 변화되는데, 그중에서도 술전의 신기능은 일측 뿐 아니라 양측성 수신증의 초기 치료 지침을 세우는데 매우 중요한 의미를 가진다. 따라서 저자들은 일측성 수신증(폐색과 역류)을 가진 환아에서 환측신의 치료전과 후 상대적 신기능의 변화를 관찰하여 수신증의 예후에 미치는 영향을 관찰하고자 하였다. 방법 : 1992년 3월부터 1997년 2월까지 수술적으로 교정한 수신증 환자 393명(폐색성 108, 역류성 285)중 술후에 합병증 없이 치료가 끝나고 수술전후에 자료가 충실한 81명(폐색성 35, 역류성 46)을 대상으로 하였다. 환자들의 평균 나이는 폐색 환자에서 2.62(0.02-15)세, 역류 환자에서 3.14(0.5-15)세였으며, 평균 추적관찰 기간은 2.01(0.25-4)년이었다. 상대적 신기능은 폐색 환자에서 $^{99m}Tc-DTPA$(31명)와 $MAG_3$(4명) scan으로 술전과 술후 3개월에, 역류 환자에서는 DMSA scan(46명)으로 술전과 술후 6개월에 측정하였다. 분석은 폐색과 역류성 수신증의 두군에서 각각 술전후의 신기능 변화를 관찰하였으며, 가장 큰 영향을 미치는 인자를 찾고자 하였다. 통계는 student t-test를 사용하였고 p value는 0.05이하일 때 유의한 차이가 있는 것으로 간주하였다. 결과 : 1. 폐색성 수신증: 전체 평균적으로 수술전 37.69%(3.5-50)이었던 신기능이 수술후 40.15%(4-55)로 호전되었다. 세부적으로 살펴보면 수술전 신기능이 20에서 40%까지였던 신이 20%이하나 40%이상이었던 신에서 보다 통계적으로 의미있게 술후 신기능이 호전되었다. 2. 역류성 수신증: 전체 평균적으로 수술전 34.27%(3-49)이었던 신기능이 수술후 33.61%(3-49)로 통계적으로 의미있는 호전을 보이지 않았다. 역류에서는 술후 신기능이 통계적으로 의의있는 변화를 보이는 어떤 술전 신기능의 값도 발견할 수 없었다. 결론 : 신우요관 이행부 폐색에 의한 수신증에서는 술전 신기능이 20에서 40%사이의 신에서 신기능의 증가를 기대하고 수술을 시행할 수 있으리라 생각되지만, 실제 기준이 되는 수치에 대한 것은 더 연구가 필요하리라 생각된다. 방광요관역류에서는 술후 신기능의 증가를 보이지 않아 수술의 목적은 신기능의 증가를 위한 것보다도 술전 기능을 유지하거나 제어되지않는 요로감염등과 같은 증상의 치유를 위해 치료방법으로 선택해야 한다. Purpose: The information on the change of the relative renal function after operation is essential to set the initial treatment plan in unilateral hydronephrosis. So we analyzed the preoperative and postoperative relative renal function, and observed the functional changes by operation and reliability of the various factors in those changes. Materials and Methods: A retrospective trial was done of 81 patients, 35 ureteropelvic junction(UPJ) obstruction and 46 vesicoureteral reflux(VUR), among 393 patients undergoing operations at our institution from March. 1992 to February. 1997. The patients who had infravesical abnormalities, abnormal contralateral kidney and insufficient research data were excluded. We determined the relative renal functions using DTPA and MAG3 scan in UPJ obstruction and DMSA scan in VUR. The mean observation period after operation was 2.01(0.25-4) years. Results: A. UPJ Obstruction 1. The relative renal function was improved significantly after operation(P=0.0007). 2. The kidneys which have preoperative functions between 20% and 40% improved significantly in relative renal function comparing to the kidneys of the other functions(P=0.0046). B. VUR 1. The renal functions didn't improve significantly after operation(P>0.05). 2. There was no significant factor affecting the prognosis in renal functions. Conclusions: 1. The kidneys with UPJ Obstruction show the difference in functional improvement after operation according to the degree of the preoperative renal function, but more investigations about the exact value are needed. 2. In VUR there was no difference between preoperative and postoperative functions, the theoretical basis on objectives of the operation could be the symptoms or factors except the operation.

鹿茸藥鍼이 骨形成에 미치는 影響

한상원,최제용,이윤호 대한침구학회 2001 대한침구의학회지 Vol.18 No.5

Objective : Bone homeostasis is maintained by balance of bone formation and resorption. Therefore, bone related diseases arose by disturbance of this balance between osteoblast and osteoclast activities. To develop a successful screening system of the therapeutic components based on oriental medicine is essential to set out systematic approach for that purpose. Methods : This study was perforated Sprague-Dawley rat femur for bony defects(φ 5㎜) by the fissure bur. And experimetal group were treated with Cervi Pantotricuhum Cornu injection at both She`nshu~(BL23) & Da`zhu`(BL11)(0.2㎖). This was evaluated by radiography and histological analysis with in situ hybridization. Results : Cervi Pantotricuhum Cornu Herbal Acupuncture has weak effect on bony defect healing and this was evaluated by X-ray taking and histological analysis with in situ hybridization. Osteocalcin gene expression was not changed by Cervi Pantotricuhum Cornu Herbal Acupuncture in bony defects animal model. Conclusion : Taken together this study show that the Cervi Pantotricuhum Cornu herbal-acupuncture has a weak effect healing of bony defects, this type of approach might give a good chance to explore the favorable effects of Cervi Pantotricuhum Cornu herbal-acupuncture on bone tissue.