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표명윤,Hae Ju Kim,Seung Kyung Back,양미희 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.11
Bisphenol A (BPA) is an environmental endocrine disrupter that is known to be transferred to the fetus via the placenta and to the neonate via milk. In this study, we investigated BPAinduced alterations of the activities of murine peritoneal macrophages in dams and 7 week old offspring of dams exposed to BPA from gestational day 7 until lactation on day 21 after delivery, i.e. 34-36 days. BPA was administered in drinking water at three doses, 15, 75, and 300 mg/L. Dams were sacrificed 21 days after delivery and offspring at the age of 7 weeks. Peritoneal macrophages were cultured in the presence of LPS or LPS plus IFN-γ for 2 or 4 days. We found that nitric oxide (NO) production by maternal macrophages was significantly decreased in a BPA-dose dependent manner. However, while a significant reduction of NO production by macrophages in the offspring was observed at BPA concentrations of 75 mg/L and 300 mg/L in drinking water, this effect was not seen at the lowest concentration of 15 mg/L. Similar inhibition of tumor necrosis factor-α (TNF-α) production was observed with macrophages from both BPA-exposed dams and offspring. Thus, our results suggest that exposure to BPA during gestation and lactation induces downregulation of the activities of macrophages in both dams and offspring.
Dextromethorphan 이 마우스의 비장세포 증식능과 cytokine 생성능에 미치는 영향
표명윤,황유경 숙명여자대학교 약학연구소 2004 약학논문집-숙명여자대학교 Vol.21 No.-
Dextromethorphan hydrobromide (DXM) has been widely used as a nonopioid antitussive drug and is a psychotropic drug since 2003 in our country. This study was performed to investigate the immunotoxicity of DXM by assay of splenocytes proliferation (SP) and induction of cytokine (IFN-γ, IL-4) in vitro. When mouse splenocytes were exposed to various concentration of DXM (0.001, 0.01, 0.1, 1, 10, 100μM) and cultured with T cell mitogen (Con A) or B cell mitogen (LPS), SP to Con A and LPS were significantly decreased at high concentration (100μM) when compared with controls. When splenocytes were cultured with DXM in the presence of Con A, levels of IFN-γ in culture supernatant were slightly decreased at low concentration, and significantly decreased at high concentration (100μM). DXM also suppressed IL-4 secretion significantly at 100μM, however, increased the production of IL-4 at lower concentration when compared with control group. This study provides the substantial evidence on DXM-induced alternation in cell-mediated and humoral immunity.
Dextromethorphan이 마우스의 자발운동량에 미치는 영향
표명윤,유경미 숙명여자대학교 약학연구소 1999 약학논문집-숙명여자대학교 Vol.16 No.-
The effect of dextromethorphan(Dex) on the spontaneous locomotor activity in mice was investigated. After Dex was intraperitoneally adminstered with the dose of 20, 60 or 80 mg/kg/day once a day for 1 day, 4 days or 7 days in female ICR mice. The spontaneous locomotor activity such as distance traveled(DT) was observed for 3.5 hrs at 15 min intervals. The spontaneous locomotor activity was markedly increased and showed to be biphasic in a dose dependent manner.
표명윤,윤지현 대한약학회 1999 약학회지 Vol.43 No.1
We investigated effects of methanol extract of Aloe vera on anticancer drugs(cisplatin, mitomycin C, 5-fluorouracil)-induced growth inhibition in p388, L1210, HCT-15, SK-HepG-1 as cancer cell lines and mouse splenocytes as a normal cell by MTT assay, respectively. We also examined the effects of aloe extract and mitomycin C on the mitogen(Con, A, LPS)-induced splenocyte proliferation. Aloe extract(0.25 mg/m , 1.25 mg/m , 2.5 mg/m , 5.0 mg/m ) showed dose-dependently selective cytotoxicity against the cancer cell lines. In contrast, Aloe extract increased the growth and proliferation of the normal mouse splenocytes. The combination of aloe extract with anticancer drugs showed an additive effect for the cytotoxicity against cancer cell lines. However, that combination reduced clealy the anticancer drugs-induced toxicity against the normal mouse splenocytes.
2- [4-cyanophenyl)amino)]-3-chIoro-1,4-naph thalened ione (NQ-Y15)가 마우스의 면역병리 및 체액성 면역에 미치는 영향
표명윤 숙명여자대학교 약학연구소 2002 약학논문집-숙명여자대학교 Vol.18 No.-
In order to investigate the effects of 2-[(4-cyanophenyl)amino]-3-chloro-l,4-naphthalenedione (NQ-Y15) on immune system in mice, we examined the immunopathological parameters and splenic IgM plaque forming cells (PFC) in this study. The immunopathological parameters (weights of body and organs, hematological parameters) were examined on day 1, 2,4 and 6 following single oral administration of NQ-Y15 (125, 250, 500 mg/kg) to female ICR mice. The weight of body was not changed. However, the weights of organs were slighty increased, and among hematological parameters WBC and platelet (PLT) were slightly changed in a dose- and test day-dependent manner when compared with control group. When NQ-Y15 was administered before immunization with SRBCantigen, PFC was significantly and dose-independently enhanced, but PFC was slightly decreased only at a high dose of NQ-Y15 when administered after antigenic challenge. These results indicate that the effects of NQ-Y15 on primary humoral immune response may be dependent on the timing of its administration relative to the initial antigenic challenge.
표명윤,유경미,최지선,오현정 숙명여자대학교 약학연구소 1993 약학논문집-숙명여자대학교 Vol.9 No.-
Effects of a new platinum complex, tetrachloro-[bis(2-chloroethyl) ethylenediamine-N,N']platinum(IV)[PtCl₄-2(CEen)] and cisplatin on the immune response were investigated. Male ICR mice were treated at the respective LD50(20% or 60% LD50) of cisplatin and PtCl₄-2(CEen). The results were as following : LD50 of PtCl₄-2(CEen) for male ICR mouse was 122.5mg/kg(i.p.) and higher than cisplatin(16.3mg/kg, i.p.). Body-, spleen-, thymus-, liver-weight, number of WBC and RBC were reduced dependently on the dose and day of administeration of cisplatin and PtCl₄-2(CEen). But these toxicities produced by PtC^-^CEen) appeared to be relatively less and to improve faster than by cisplatin. The titers of hemagglutinin and hemolysin to SRBC in mice received cisplatin and PtCl₄-2(CEen) were decreased significantly and independently on the day of antigen injection. Cisplatin and PtCl₄-2(CEen) stimulated significantly contact hypersensitivity to DNFB when administered prior to sensitization(DNFB), but suppressed slightly when administered after sensitization.
Cyclophosphamide에 의한 세포성 면역반응의 조정에 관한 연구
表明允 淑明女子大學校 1986 論文集 Vol.27 No.-
Varying combinations of cyclophosphamide (CY, single dose at day-6∼day +4) plus allo-transplantation antigen (allo-TA, lymphocytes from C3H mice at day 0) were injected into normal or presensitized Balb/c mice. The resulting T-effector cell reactivity was determined in vitro with mirocytotoxicity test and the mechanism responsible for the effect of CY on the cell-mediated immunity (CMI) was studied with one way-mixed lymphocyte culture (MLC). The results were as follows : (1) LD_50 of CY for female Balb/c mouse was 510mg/kg body weight (i.p.). (2) CY showed immunostimulative effect when administered prior to allo-TA, and immunosuppressive effect when administered after allo-TA on both of the primary and secondary CML.(3) Change of the dose of CY (20%, 60% LD_50) caused only quantitative variation in the immunomodulating effect. (4) The reduced MLC reactivity of normal lymphocytes was induced by CY and antigen-treated lymphocytes. This results support that CY activates the mitomycin C-nonsensitive T suppressor cell but not T Helper cell.