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Therapeutic Hypothermia for Cardioprotection in Acute Myocardial Infarction
편욱범,강인숙,Ikeno Fumiaki 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.2
Mild therapeutic hypothermia of 32–35°C improved neurologic outcomes in outside hospital cardiac arrest survivor. Furthermore,in experimental studies on infarcted model and pilot studies on conscious patients with acute myocardial infarction, therapeutichypothermia successfully reduced infarct size and microvascular resistance. Therefore, mild therapeutic hypothermia has received an attention as a promising solution for reduction of infarction size after acute myocardial infarction which are not completelysolved despite of optimal reperfusion therapy. Nevertheless, the results from randomized clinical trials failed to prove the cardioprotective effects of therapeutic hypothermia or showed beneficial effects only in limited subgroups. In this article, we reviewedrationale for therapeutic hypothermia and possible mechanisms from previous studies, effective methods for clinical applicationto the patients with acute myocardial infarction, lessons from current clinical trials and future directions.
Cardiovascular Disease in Women
편욱범,신길자 대한심장학회 2006 Korean Circulation Journal Vol.36 No.12
More women have died from cardiovascular disease since middle 1980’s than men due to the women’s older ageand multiple comorbid conditions. Additionally, women with acute coronary syndrome have worse outcomes, includingsudden cardiac death and death before arriving to the hospital, due to the women’s atypical symptoms andthe delayed diagnosis and treatment. There are many reports on the gender-specific differences in the pathophysiologyof ischemic heart disease. In addition to the previous reports, the WISE study was started for improvingboth our understanding and the clinical outcomes of ischemic heart disease of women. These studies have suggestedthe structural and functional differences in the female vasculature, new paradigms for the diagnosis and treatmentof the ischemic heart disease of women, the various roles of estrogen and the new therapeutic targets forpreventing ischemic heart disease (IHD) or improving cardiovascular outcomes. On-going and future studies shouldfocus on further understanding of the pathophysiology, the clinical usefulness of the new diagnostic markers thatmay related to the IHD of women, and the development of non-invasive, easily reproducible diagnostic tools for earlydetection of IHD and for predicting the adverse outcomes. (Korean Circulation J 2006;36:771-779)
Are Statins Beneficial for Patients With Heart Failure?
편욱범 대한심장학회 2008 Korean Circulation Journal Vol.38 No.4
There is a tremendous amount of evidence about the beneficial roles of statins, as related to primary and their patients regardless of the left ventricular systolic function, and especially for patients with old myocardial infarction. After the report on the post-hoc analysis of the Scandinavian Simvastatin Survival Study, there have been many reports about the roles of statins for the patients with heart failure from ischemic or non-ischemic etiologies. But most of these reports were non-randomized, observational, post-hoc subgroup analyses and small prospective short term studies, and the power of the evidence was too weak to set a guideline for statin therapy in patients with heart failure. The conclusions of the previous reports were that two large prospective randomiz-multiNAtional trial in heart failure (CORONA) study was presented and many cardiologists believed that this study did not resolve the lack of evidence for the current practice of administering statins to heart failure patients with ischemic heart disease, but it proved the safety of administering 10 mg of rosuvastatin. So, we review the potential benefits of statins, beyond the cholesterol lowering effects in patients with heart failure, and we will reexamine the use of statins in patients with heart failure after the CORONA study.
편욱범 대한가정의학회 2002 Korean Journal of Family Medicine Vol.23 No.12
심혈관 질환은 전 세계적으로 가장 흔한 질환 및 사망원인의 하나로 여러 연구에서 심혈관 질환의 위험인자가 밝혀지고, 이를 조절함으로 예방이 가능한 것으로 알려져 있다. 그래서 20세 이상의 성인에서 심혈관 질환의 위험인자의 종류와 중요성을 이해시키고, 철저히 위험인자에 대해 조사하고 심혈관 질환의 위험도를 평가하여, 그 위험도에 따른 치료를 권장하고 있다. 이미 잘 알려진 흡연, 고혈압, 고지혈증 그리고 당뇨병의 네 가지 중요한 위험인자 외에 나이, 성별, 고비중지단백 콜레스테롤(HDL-cholesterol)을 지수로 하여 10년 내에 심혈관 질환의 위험도를 계산하는 Framingham의 계산법이 임상에서 유용하게 이용될 수 있다. 이에 따라 조절하거나 제거하여 심혈관 질환을 예방할 수 있는 위험인자들의 관리지침을 알아보고, 1차 임상의로 심혈관 질환의 예방에 이용될 수 있도록 한다. (가정의학회지 2002;23:1405-1411)