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카살라,김민상,김봉섭,이두성 한국고분자학회 2007 Macromolecular Research Vol.15 No.4
aqueous medium. The hydrophilic and hydrophobic blocks form shell and core micelles, respectively. The block copolymers of methoxy poly(ethylene glycol) (MPEG)-b-poly(2-diisopropylamino)ethyl methacrylate (PDPA) were synthesized via atom transfer radical polymerization, with the macroinitiator synthesized by the coupling of 2-bromoisobutyryl bromide with MPEG in the presence of a triethyl amine base catalyst. The atom transfer radical polymerization of 2-diisopropylamino)ethyl methacrylate was performed in conjunction with an N,N,N',N'',N''-pentamethyl-diethylenetriamine/copper bromide catalyst system, in DMF, at 70oC. The pH induced micellization/demicellization was studied using fluorescence, with a pyrene probe. Furthermore, the pH dependent micellization was confirmed using the microviscosity method, with a dipyme fluorescence probe. The pH dependant micelle size distribution was studied using dynamic light scattering. The characterization of the synthesized polymers was established using gel permeation chromatography and from the 1H-nuclear magnetic resonance spectroscopy.
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Endosomal pH-destabilized PGA-PCL block copolymer micelle
김민상,카살라,Guang Jin Im,김봉섭,Doo Sung Lee 한국생체재료학회 2009 생체재료학회지 Vol.13 No.3
Poly(L-glutamic acid)-poly(ε-caprolactone) diblock copolymers were prepared using ring opening polymerization. The diblock copolymers were characterized by 1H-NMR, gel permeation chromatography and FT-IR. Endosomal pH-destabilized nanoparticles were prepared from dialysis method and their micellar structure was confirmed by dynamic light scattering and transmission electron microscopy. In this study, the method of fabrication and pHdependent structural changes of the diblock copolymer were investigated. pH-Dependent changeable nanoparticles may be helpful for intracellular delivery in drug delivery systems.
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