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췌담관 질환 환자에서 담즙내 carcinoembryonic antigen의 진단적 역할
추연익 ( Chu Yeon Ig ),주광로 ( Ju Gwang Lo ),박종호 ( Park Jong Ho ),방성조 ( Bang Seong Jo ),김도하 ( Kim Do Ha ),신정우 ( Sin Jeong U ),박능화 ( Park Neung Hwa ),박재후 ( Park Jae Hu ),이지호 ( Lee Ji Ho ) 대한내과학회 2003 대한내과학회지 Vol.65 No.5
목적 : 혈청이나 조직 이외 체액을 이용한 CEA 검사는 종양과 인접하여 있거나 종양 자체를 감싸고 있는 검체를 이용하므로 혈청 CEA보다 진단적 가치가 높다는 일부 보고가 있다. 따라서 본 연구는 췌담관 질환에서 양성과 악성의 감별에 담즙 CEA의 진단적 역할을 알아보고자 하였다. 방법 : 췌담관 질환을 가진 121명 환자를 대상으로 전향적으로 연구를 하였다. 환자는 대조군, 양성질환군, 악성질환군의 세 군으로 나누었고 각각의 환자수는 21명, 57명 Background : Recently there has been notion that fluids bathing tumors might contain higher levels of carcinoembryonic antigen (CEA) than those found in the blood. Thus, we evaluated the diagnostic role of biliary CEA in patients with pancreatobiliary dis
췌담관질환이 있는 환자의 간흡충 진단에서 피내검사의 유용성 평가
주광로 ( Ju Gwang Lo ),이미숙 ( Lee Mi Sug ),윤태권 ( Yun Tae Gwon ),추연익 ( Chu Yeon Ig ),이진우 ( Lee Jin U ),조영철 ( Jo Yeong Cheol ),김대현 ( Kim Dae Hyeon ),김도하 ( Kim Do Ha ),박능화 ( Park Neung Hwa ),박재후 ( Park Jae H 대한소화기학회 2003 대한소화기학회지 Vol.42 No.3
Background/Aims: The diagnosis of clonorchiasis is based on demonstrating eggs in stool or bile. It is believed that bile examination is the most precise method for detecting eggs. We evaluated diagnostic usefulness of intradermal test (IDT) by comparing it with the result of bile examination. Methods: For 88 patients with pancreatobiliary diseases, we examined Clonorchis sinensis eggs in bile and performed IDT for clonorchiasis. The bile was obtained from endoscopic nasobiliary or percutaneous transhepatic biliary drainage tubes. Results: We calculated ROC curve to decide the cut-off value of IDT in determining diagnostic accuracy on the basis of bile examination. We chose a value of 40 mm2, which significantly improved the sensitivity, without reducing the specificity. With a cut-off value of 40 mm2, the sensitivity, specificity, positive and negative predictive values of IDT were 81.5%, 67.2%, 52.4%, and 89.1%, respectively. The value of IDT was not affected by age and showed no difference between benign and malignant diseases. However, in egg-positive patients, the mean value was lower in malignant diseases than in benign diseases. Conclusions: In patients with pancreatobiliary diseases, IDT with a cut-off value of 40 mm2 seems to be a valuable supplementary diagnostic test for clonorchiasis in view of its high sensitivity. (Korean J Gastroenterol 2003;42:232-236)