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국가별 참억새 수집종의 총 페놀 및 플라보노이드 성분 분석
최혜림,최승혁,최재후,이현우,유지혜,성은수,이재근,허권,유창연 한국약용작물학회 2018 한국약용작물학술대회 발표집 Vol.2018 No.10
Background : Miscanthus sinensis is a C4 crop with high photosynthetic efficiency and is known as a representative cellulose-based bio-energy crop originating in East Asia such as Korea, Japan, and China. It also has a high resistance to environmental conditions such as low temperature and drying and pests. However, many studies on the antioxidant activity of the M. sinensis have not been conducted. Therefore, this study was conducted to measure total phenol and total flavonoid contents of the M. sinensis accessions collected from some countries and to select the M. sinensis accessions with rich total phenol and total flavonoid contents. The results of this study can be used as basic data for future breeding. Methods and Results : This study carried out the total phenol and total flavonoid contents analysis of M. sinensis collected from different country to preserve genetic resources. Total 205 accessions of M. sinensis were collected from the USA, China, Korea, Japan, Thailand and Zambia. Their leaves were extracted with 100% methanol and concentrated at 45℃. To determine total phenol and total flavonoid contents, we measured the total phenolic content and total flavonoid content. The highest total phenolic conten t(81.04 ± 0.02 ㎎·GAE/g) showed in the accession (PMS-178) from China. The highest total flavonoid content (32.66 ± 0.01 ㎎·QE/g) showed in the accession (KMS104) from Korea. On the other hand the lowest total phenolic content (1.11 ± 0.00 ㎎·GAE/g) and the total flavonoid content (0.81 ± 0.00 ㎎·QE/g) were obtained from the accession (M. sinensis ‘Super Stripe’) from USA. Conclusion : In this study, we analysed the total phenolic and total flavonoid contents by country of origin.
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CNTs 합성을 통해 향상된 비표면적을 갖는 Ti 다공체의 제조
최혜림,변종민,석명진,오승탁,김영도,Choi, Hye Rim,Byun, Jong Min,Suk, Myung-Jin,Oh, Sung-Tag,Kim, Young Do 한국분말야금학회 2016 한국분말재료학회지 (KPMI) Vol.23 No.3
This study is performed to fabricate a Ti porous body by freeze drying process using titanium hydride ($TiH_2$) powder and camphene. Then, the Ti porous body is employed to synthesize carbon nanotubes (CNTs) using thermal catalytic chemical vapor deposition (CCVD) with Fe catalyst and methane ($CH_4$) gas to increase the specific surface area. The synthesized Ti porous body has $100{\mu}M$-sized macropores and $10-30{\mu}m$-sized micropores. The synthesized CNTs have random directions and are entangled with adjacent CNTs. The CNTs have a bamboo-like structure, and their average diameter is about 50 nm. The Fe nano-particles observed at the tip of the CNTs indicate that the tip growth model is applicable. The specific surface area of the CNT-coated Ti porous body is about 20 times larger than that of the raw Ti porous body. These CNT-coated Ti porous bodies are expected to be used as filters or catalyst supports.
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리츠편입을 통한 복합자산 포트폴리오의 분산효과 분석: 국제금융위기 전·후 기간을 중심으로
최혜림,유정석 국토연구원 2011 국토연구 Vol.71 No.-
During the recent sub-prime mortgage crisis, real estate investors recognized that systematic risks could not be easily avoided by way of portfolio diversification due to the strong co-movements among international real estate capital markets. Therefore, this study provides re-examinations on real estate portfolio diversification effects under uncertain investment environments. To analyze the stability of diversification effects across investment horizons, rolling correlation, Granger causality, and cointegrating relations are tested to examine short- and long-run diversification effects. The main research findings of this paper are as follows. First, during the period of regime-changes it is very unlikely to expect portfolio diversification effects because risk-return tradeoffs and correlation relations among assets become unstable in the short run. Second, diversification effects are very limited during the crisis due to the higher correlations and strong spill-over effects between real estate and financial assets. Finally, after the international financial crisis, real estate and domestic capital markets performed differently. Therefore, real estate investors should consider portfolio re-balancing in a timely manner and readjust their optimal asset allocation strategies to maximize their portfolio investment performances, measured by Sharpe ratio, to reflect real estate investment environmental changes. 최근 국제 금융위기 동안 투자자는 투자자산의 강한 동조화 현상으로 분산투자를 하더라도 체계적 위험까지 모두 제거할 수 없음을 경험하였다. 이에 따라 본 연구는 불확실한 투자환경 하에서의 투자 포트폴리오 효과를 재검증하였다. 투자자산의 안정성 검증 및 이동상관분석, 그랜저인과분석, 공적분 검정을 통해 장·단기 분산효과를 분석하여 다음과 같은 결과를 얻을 수 있었다. 첫째, 연구기간동안 변동성이 심한 단기에는 자산 간 상관관계 및 위험-수익관계가 상쇄되어 효과적인 분산효과를 기대하기 어려웠다. 둘째, 부동산-금융자산 간 높은 상관관계와 강한 동조화 현상은 국제 금융위기 동안 투자 포트폴리오의 분산효과를 제한하였다. 셋째, 국제 금융위기 이후 국내 금융자산과 부동산 투자자산 간 수익률 변화는 달라진 양상을 보였다. 그 결과 투자자 입장에서 투자 포트폴리오 성과를 극대화하기 위해 부동산 투자환경 변화를 반영한 시기적절한 포트폴리오 리밸런싱이 필요함을 알 수 있었다.
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최혜림,최승혁,최재후,이지영,유지혜,성은수,김나영,유창연 한국약용작물학회 2018 한국약용작물학술대회 발표집 Vol.2018 No.05
Background : Sorghum(Sorghum bicolor) is the fifth most important crop in the world. Although it is known as a crop with many medicinal action, Studies on sorghum breeding are inferior to other crop. Therefore, it is necessary to cultivate excellent varieties of sorghum which is stable and has excellent physiological activity. So, this study was conducted to investigate the antioxidant activity of the sorghum species and to select the sorghum species with high antioxidant activity. The results of this study could be used as basic data for high-function breeding. Methods and Results : The seeds for study were supplied from the Center for Agricultural Genetic Resources of National Institute of Agricultural Sciences. The seeds were extracted with 100% methanol and concentrated at 45℃. To determine antioxidant activity, we measured the DPPH radical scavenging ability and ABTS radical scavenging ability. The highest DPPH radical scavenging activity showed in the accession from IT No. 158264 (RC50 : 5968.71 ± 4986.24 ㎍/㎖) and the ABTS radical scavenging activity showed the highest in IT No. 143744 (RC50 : 1558.47 ± 273.21 ㎍/㎖). On the other hand the lowest DPPH radical scavenging activity showed in the accession from IT No. 155497 (RC50 : 3.26 ± 20.06 ㎍/㎖) and the ABTS radical scavenging activity showed the lowest in IT No. 152910 (RC50 : 3.31 ± 20.10 ㎍/㎖). Conclusion : Among 300 sorghum accessions, we analysed the antioxidant activities of DPPH and ABTS.
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최혜림,하지선,김인식,양승주,Choi, Hye-Rim,Ha, Ji Sun,Kim, In Sik,Yang, Seung-Ju Korean Society for Clinical Laboratory Science 2020 대한임상검사과학회지(KJCLS) Vol.52 No.3
알츠하이머 병은 인지 기능 저하로 인한 치매 발생으로 설명할 수 있는 만성 및 진행성 신경 퇴행성 질환이다. 알츠하이머 병의 특징은 세포 외 및 세포 내 아밀로이드 플라크의 형성이다. 아밀로이드 베타는 알츠하이머 병의 특징이며 미세아교세포는 아밀로이드 베타의 존재하에 활성화될 수 있다. 활성화된 미세아교세포는 전 염증성 사이토카인을 분비한다. 게다가, S100A9는 염증의 중요한 선천성 전 염증 기여자이며 알츠하이머 병에 잠재적인 기여자로 알려져 있다. 이 연구는 아밀로이드 베타 및 S100A9이 처리된 BV-2 세포에서 염증반응 및 NLRP3 인플라마솜 활성화에 대한 메트포르민 및 알파리포산의 효과를 조사했다. 메트포르민과 알파-리포산은 종양 괴사 인자-알파 및 일터루킨-6와 같은 염증성 사이토카인을 약화시킨다. 또한 메트포르민과 알파-리포산은 JNK, ERK, p38의 인산화를 억제하고, NF-kB 경로 및 NLRP3 인플라마솜의 활성화를 억제했다. 또한 메트포르민과 알파-리포산은 M1 표현형인 ICAM1의 수준을 감소시킨 반면 M2 표현형인 ARG1은 증가시켰다. 이러한 발견은 메트포르민과 알파-리포산이 아밀로이드베타 및 S100A9에 의한 신경 염증 반응에 대한 치료제가 될 수 있음을 시사한다. Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disease that can be described by the occurrence of dementia due to a decline in cognitive function. The disease is characterized by the formation of extracellular and intracellular amyloid plaques. Amyloid beta (Aβ) is a hallmark of AD, and microglia can be activated in the presence of Aβ. Activated microglia secrete pro-inflammatory cytokines. Furthermore, S100A9 is an important innate immunity pro-inflammatory contributor in inflammation and a potential contributor to AD. This study examined the effects of metformin and α-LA on the inflammatory response and NLRP3 inflammasome activation in Aβ- and S100A9-induced BV-2 microglial cells. Metformin and α-LA attenuated inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). In addition, metformin and α-LA inhibited the phosphorylation of JNK, ERK, and p38. They activated the nuclear factor kappa B (NF-κB) pathway and the NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome. Moreover, metformin and α-LA reduced the marker levels of the M1 phenotype, ICAM1, whereas the M2 phenotype, ARG1, was increased. These findings suggest that metformin and α-LA are therapeutic agents against the Aβ- and S100A9-induced neuroinflammatory responses.
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