발효 전후 구기자열매 추출물의 ADH 및 ALDH 활성인자 분리 및 특성

최지현(Ji-Hyun Choi),강동희(Dong-Hee Kang),김현수(Hyun-Soo Kim) 한국생물공학회 2016 KSBB Journal Vol.31 No.2

Lycii fructus has been traditionally used as a preventive and therapeutic medicine to treat enervation and diverse chronic diseases. In this study, we investigated whether fermentation of Lycii fructus extract (LE) increases the enzymatic activity of the alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). The fermentation of LE by Bacillus subtilis subsp. subtilis and Saccharomyces cerevisiae IFO 2376 was shown to increase the enzymatic activity of ADH and ALDH. TLC analysis of LE and fermented LE (FLE) showed that ADH and ALDH activities increased in different spots. Fraction No. 66 of LE and fraction No. 68 of FLE by Silica gel chromatography showed increased ADH activity of 129.1% and 148.9%, respectively. Fractions No. 128 of LE and FLE by Silica gel chromatography showed increased ALDH activity of 134.1% and 148.1%, respectively. The fraction No. 68 of FLE obtained by HPLC showed new peaks at Rt 11.938min, Rt 22.072min and Rt 28.842min, indicating that ADH activity was increased. The LE and FLE fractions with the greatest increases in ADH activity peaked at the same time (Rt 13min),whereas the LE and FLE fractions with the greatest increases in ALDH activity peaked at different times (Rt 16.307min and Rt 36.640min, respectively).

눈꺼풀에 발생한 피부 림프상피종 양 암

최지현 ( Ji Hyun Choi ),김건 ( Geon Kim ),심현철 ( Hyun Chul Shim ),김지혜 ( Ji Hye Kim ),김은정 ( Eun Jung Kim ),박향준 ( Hyang Joon Park ),조옥자 ( Ok Ja Joh ),송계용 ( Kye Yong Song ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.5

Lymphoepithelioma-like carcinoma is a neoplasm at extranasal sites with striking histological similarity to lymphoepithelioma arising in the nasopharynx. The tumor is composed of islands of pleomorphic cells with a lymphocytic infiltrate. The head and neck are the principal locations for this tumor, which occurs in the skin. Differential diagnoses include squamous cell carcinoma, Merkel cell tumor, lymphoma, cutaneous lymphadenoma, malignant melanoma, and metastatic lymphoepithelioma. Here, we report a case of lymphoepithelioma-like carcinoma of the skin in a 78 year-old male who had a firm nodule on the right upper eyelid. He was treated with wide excision and local flap coverage. The patient had been disease-free for more than 1 year. (Korean J Dermatol 2011;49(5):477∼479)

Isotretinoin 경구투여로 호전된 Langerhans Cell Histiocytosis

최지현 ( Ji Hyun Choi ),심현철 ( Hyun Chul Shim ),김지혜 ( Ji Hye Kim ),김준범 ( June Bum Kim ),신미선 ( Mi Seon Shin ),박향준 ( Hyang Joon Park ),이재승 ( Jae Seung Lee ),조옥자 ( Ok Ja Jo ),송계용 ( Kye Yong Song ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.10

Langerhans cell histiocytosis (LCH) is a reactive disease in which abnormal Langerhans cells accumulate in various body sites. We report here on a 51-year-old male patient with LCH that was classified as single-system disease (restricted LCH). The skin lesions were a small, deep ulcer in the right inguinal area and multiple erythematous papules scattered on the lower abdomen, and the patient had these lesions for 1 year. The histopathologic examination revealed a dense histiocytic infiltration in the dermis, and most of the cells showed the characteristics of “LCH” cells. The immunohistochemistry for S-100 protein and CD1a complex all showed positive results. The patient was much improved after surgical excision of the inguinal ulcer and administering oral isotretinoin (20 mg daily) for 8 months, and there was no recurrence. We think retinoid is an effective treatment option for LCH, especially for single system disease. (Korean J Dermatol 2010;48(10):893~897)

우리나라 대학 AI 교양교육 설계를 위한 미국과 독일의 대학 AI 교양교육 현황 분석 연구

최지현 ( Choi Ji Hyun Kim ),김형주 ( Hyeong Joo ) 중앙대학교 인문콘텐츠연구소 2021 인공지능인문학연구 Vol.7 No.-

본 연구는 국내 AI 교양교육 설계를 위한 토대를 마련하고자, 미국과 독일 대학의 교양교육 현황에 대한 사례를 조사하였다. AI 교육과 관련된 미국의 국가정책을 소개하였고 미국의 총 20개 대학의 사례를 조사하였다. 미국의 AI 교양교육으로는 세 가지 유형이 확인되었는데, 첫째, AI에 대한 인문학적, 철학적, 사회과학적 논의가 필요한 과목, 둘째, 비과학 전공자를 위한 과학 입문 과목, 셋째, 다른 전공과 융합된 교육과목이다. 독일의 사례에서는 ‘디지털 인문학’이라는 학문 단위로 엮어 요약된 독일 전역 총 12개 대학의 인공지능 관련 융합 교과에 대한 소개를 시도하였다. 독일과 미국의 사례를 토대로 국내 AI 교양교육을 위해 첫째, 전공을 불문하고 모든 학생을 위한 AI 기본 교육, 둘째, 기존의 개별 전공과 융합된 학제 간 AI 교육, 셋째, 비과학 전공자의 학문적 연속성을 보장할 수 있는 다양하고 단계적인 AI·컴퓨터 관련 교육 설계를 제언하였다. AI 교양교육이 융합 교육이라는 측면에서 인문학과 기술공학이 융합된 미국과 독일의 AI 교양교육의 사례들은 큰 시사점을 남긴다고 할 수 있고, 국내 AI 교양교육 설계를 위한 참고자료를 마련하였다는 점에 본 연구의 의의가 있다. In order to lay the groundwork for the design of AI liberal arts education in Korean universities, this study investigated cases of liberal arts education in US and German universities. Three types of AI liberal arts education in the United States were identified. First, subjects that require humanities, philosophical, and social science discussions on AI, second, science introductory subjects for non-science majors, and third, subjects that converge AI with other majors. In the case of Germany, an attempt was made to introduce convergence subjects related to artificial intelligence at 12 universities across Germany, which are summarized in the academic unit called “digital humanities”. Based on the cases of Germany and the United States, first, AI basic education for all students regardless of major, second, interdisciplinary AI education integrated with existing individual majors, and third, various and step-by-step AI·computer-related education designs in which continuity of study for non-science majors are guaranteed are suggested for Korean AI liberal arts education.

대음순에 발생한 다발성 거대 물렁 섬유종

김지혜 ( Ji Hye Kim ),심현철 ( Hyun Chul Shim ),최지현 ( Ji Hyun Choi ),김준범 ( June Bum Kim ),신미선 ( Mi Seon Shin ),박향준 ( Hyang Joon Park ),조옥자 ( Ok Ja Joh ),송계용 ( Kye Yong Song ) 대한피부과학회 2010 大韓皮膚科學會誌 Vol.48 No.9

Soft fibromas are benign fibrous tissue tumors of the dermis. In general, they appear as small, soft, pedunculated or sessile tumors and they are mostly located on the axillae, lateral neck and inguinal region. Although large sized soft fibromas may occur in the groin or upper thighs, and especially in patients with diabetes, they rarely exceed 2 cm in size. We report herein a case of multiple giant soft fibromas, including an unusually huge, giant lesion in the labium majus of a healthy, middle-aged woman, and such fibromas on the labium majus are very rare. (Korean J Dermatol 2010;48(9):820~822)

단세포군 감마글로불린병증을 동반한 경화점액수종

심현철 ( Hyun Chul Shim ),김건 ( Geon Kim ),최지현 ( Ji Hyun Choi ),김지혜 ( Ji Hye Kim ),김은정 ( Eun Jung Kim ),박향준 ( Hyang Joon Park ),조옥자 ( Ok Ja Joh ),송계용 ( Kye Yong Song ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.5

Scleromyxedema is a rare disorder characterized by generalized papular and sclerodermoid eruption, increased fibroblast proliferation, mucin deposition, and monoclonal gammopathy in the absence of thyroid disease. It is a generalized subtype of lichen myxedematosus. A paraproteinemia, typically an IgG λ, is observed in more than 80% of patients with scleromyxedema. Here, we report a 38-year-old woman with a 1-year history of a progressively spreading of eruption of small papules on the entire body, including the face, neck, arms, legs, and trunk. Laboratory tests were within normal limits, except λ light chain monoclonal gammopathy. We administered oral retinoid and topical steroid with slight clinical improvement. To our knowledge, this is the first reported case of scleromyxedema in Korea. (Korean J Dermatol 2011;49(5):440∼443)

음경에 발생한 전이성 위암

김지혜 ( Ji Hye Kim ),최지현 ( Ji Hyun Choi ),김준범 ( June Bum Kim ),김학주 ( Hak Ju Kim ),박향준 ( Hyang Joon Park ),이재승 ( Jae Seung Lee ),조옥자 ( Ok Ja Joh ),송계용 ( Kye Yong Song ),최준정 ( Jun Jeong Choi ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.4

Metastatic carcinoma of the penis is rare and in most cases is associated with primary malignancy of the pelvic organs with widespread metastasis. A 64-year-old man presented with a 2 month history of skin-colored papules on his penis. He also had a history of total gastrectomy and chemotherapy due to advanced gastric carcinoma. Skin biopsy from the lesion revealed atypical polygonal cells with hyperchromatic & pleomorphic nuclei in the dermis. Results of immunohistochemical staining showed a positive reaction of CK7, and a negative reaction of CK20, PSA, and CD68. We report herein a case of metastatic cancer of the penis from gastric carcinoma. (Korean J Dermatol 2010;48(4):306~309)

초등학생의 부모애착과 시간사용 만족도가 학교적응에 미치는 영향

최지현(Ji-Hyun Choi),김수경(Su-Kyoung Kim) 대한작업치료학회 2024 대한작업치료학회지 Vol.32 No.1

목적: 본 연구는 초등학생의 부모애착과 시간사용 만족도가 학교적응에 미치는 영향을 알아보고자 하였다. 연구방법: 한국아동패널연구의 12차(2019년) 패널에 응답한 1,172명의 데이터를 추출하여 부모애착, 시간사용 만족도, 학교적응 항목을 분석하였다. 자료는 기술통계, 독립표본 t-검정, 상관분석, 위계적 다중회귀분석을 실시하여 분석하였다. 결과: 연구 결과 초등학생의 학교적응에 부모와의 의사소통과 신뢰감, 시간사용 만족감은 양의 상관관계를 부모에게서 느끼는 소외감은 음의 상관관계가 있음을 확인하였으며, 부모애착과 시간사용 만족감은 학교적응에 25%의 영향력이 있음을 확인하였다. 결론: 초등학생의 학교적응 향상을 위하여 부모는 초등학생 아동과 시간을 질적으로 보낼 필요가 있으며, 이를 위한 공적 지지나 환경의 변화 역시 필요할 것으로 사료된다. Objective: This study aimed to investigate the effects of parental attachment and time use satisfaction on school adaptation among elementary school students. Methods: Data on parental attachment, time use satisfaction, and school adaptation were extracted from 1,172 elementary school student respondents who participated in the 12th panel of the Korean Children’s Panel Study in 2019. Data were analyzed using descriptive statistics, independent t-test, correlation analysis, and hierarchical multiple regression analysis. Results: The results showed that school adaptation correlated positively with communication with parents, trust, and time use satisfaction. Conversely, it correlated negatively with feelings of alienation from parents. Parental attachment and time use satisfaction collectively accounted for 25% of the influence on school adaptation. Conclusion: To enhance children’s school adaptation, parents must invest quality time with their children. Public support and environmental changes are suggested and may be necessary to facilitate this process.

차량 노면 진동을 이용한 공진형 선형 발전기 시스템의 강건최적설계

최지현(Ji Hyun Choi),김진호(Jin Ho Kim),박상신(Sang-Shin Park),서태원(TaeWon Seo) 한국생산제조학회 2014 한국생산제조학회지 Vol.23 No.4

To use vibration energy to generate electricity, a resonance vertical linear electric generator was applied to the suspension of a vehicle in a previous paper. However, the working conditions, including mass change in the vehicle body related to the cargo on board, number of passengers and the temperature difference caused by the operating environment, can influence the permanent magnet, which is the main component of the electric generator. Therefore, a robust optimum design is required to minimize the influences from the diverse operation conditions and maximize the electromotive force of the electric generator. In this paper, a resonance linear electric generator is introduced. Vibration response analysis to find the input velocity of the electric generator and an electromagnetic transient analysis to apply changes in the performance of the permanent magnet are performed. Finally, the optimum value of each design variable is derived using a Taguchi method.

자궁근종에 대한 내시경하 근종용해술과 복강경보조 질식 자궁절제술의 비교

최지현 ( Ji Hyun Choi ),김수아 ( Soo Ah Kim ),정혁 ( Hyuk Jung ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.5

목적: 자궁근종치료에 있어 미세내시경하 자궁근종용해술 (minilaparoscopic radiofrequency myolysis, MLRFM)과 복강경보조 질식 자궁절제술 (laparoscopic-assisted vaginal hysterectomy, LAVH)의 수술 후의 임상양상을 비교 연구하기 위함이다. 연구 방법: 2006년 1월 1일부터 2009년 3월 31일까지 조선대학교병원에서 LAVH를 시행한 125명과 MLRFM을 시행한 125명을 대상으로 하였다. 결과: 평균 수술시간은 LAVH군은 69.0±31.6분, MLRFM군은 43.5±19.8분으로 유의한 차이를 보였다. 평균 출혈량은 LAVH군의 경우 215.2±215.0 mL였고, MLRFM군에서는 124예에서 인지할 만한 출혈은 없었다. 수술 후 수혈량은 LAVH군은 125예 중16예로 (12.8%) 평균 0.3±0.7 pint였고, MLRFM군에서는 수혈한 경우가 없었다. 수술 후 재원기간은 LAVH군은 평균 5.0±1.2일, MLRFM군은 2.3±1.2일로 후자가 짧은 재원 일수를 보였다. 그러나 LAVH군에서는 수술 후 출혈로 인한 수혈, 혈종을 제외하고 중증 합병증이 없었지만 MLRFM군에서는 재입원과 재수술을 필요로 하는 중증 합병증이 발생한 경우가 있었다. 결론: 향후 자궁근종의 보존적 치료 방법으로 MLRFM이 또 다른 선택사항이 될 수 있을 것으로 생각된다. Objective: To compare clinical features of minilaparoscopic radiofrequency myolysis (MLRFM) with laparoscopic-assisted vaginal hysterectomy (LAVH) in the treatment of uterine myoma. Methods: Between 1st January 2006 and 31th March 2009, 125 patients underwent LAVH and 125 patients underwent MLRFM by same surgeon at the University of Chosun Hospital, Department of Gynecology. We compared the age of patients, indication for treatment, myoma size, major symptom, duration of procedure, amounts of blood loss and postoperative transfusion, length of hospital day, postoperative complication and satisfaction between the two groups. Results: There were significant differences in duration of procedure between the LAVH group and the MLRFM group (69.0±31.6 minutes vs 43.5±19.8 minutes) and in the amounts of blood loss during procedure (215.2±215.0 mL vs 0.8±8.9 mL). The amounts of postoperative transfusion was 0.3±0.7 pints, 16 of the 125 (12.8%) for the LAVH group and no one underwent postoperative transfusion for the MLRFM group. There was significant difference in length of postoperative hospital day between the LAVH group and the MLRFM group (5.0±1.2 days vs 2.3±1.2 days). In the comparison of postoperative complications, there was no significant complication for the LAVH group, but there was major complications requiring readmission and reoperation for the MLRFM group. In MLRFM group, postoperative myoma size decreased compared to preoperative size. Conclusion: We conclude that there was no treatment of choice in uterine myoma. When considering treatment of uterine myoma, we should choose appropriate method after analyzing patient characteristics, general condition, uterine myoma characteristics case by case.