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Laparoscopic Surgery for Rectal Cancer after Preoperative Chemoradiation in Elderly Patients
최제민,이승훈,이승현,안병권 대한내시경복강경외과학회 2017 Journal of Minimally Invasive Surgery Vol.20 No.3
Purpose: Laparoscopic surgery has been accepted as a standard procedure for colorectal cancer. Preoperative chemoradiation for rectal cancer has some advantages, such as decreased tumor size and lower stage, and lower local recurrence. However, preoperative chemoradiation has the disadvantage of increasing postoperative complication risks. The aim of this study was to evaluate the safety of laparoscopic surgery for rectal cancer after preoperative chemoradiation in elderly patients. Methods: 46 p atients u nderwent l aparoscopic s urgery for rectal c ancer a fter preoperative chemoradiation. Patients were divided into younger (<70 years, n=35) and older groups (≥70 years, n=11). Results: In the younger group, men were more predominant (80% vs. 54.5%, p=0.124). In the older group, more patients had high American Society of Anesthesiologists scores (score 3 was 2.9% vs. 36.4%, p=0.005) than in the younger group. Sphincter-preserving surgery was performed more frequently in the younger group (77.2% vs. 45.5%, p=0.065). Operation time (195.8 min. vs. 212.5 min, p=0.553) and intraoperative blood loss (200.6 cc vs. 209.1 cc, p=0.952) were not significantly different. Significant anastomotic leakage was absent in both groups. Postoperative hospital stay was 9.7 and 10.9 days (p=0.669). Complete remission rates were similar in the both groups (8.8% vs. 18.2%, p=0.824). Conclusion: Postoperative outcomes are comparable between older group and younger group. Laparoscopic surgery could be considered as safe, feasible therapeutic options in elderly patients after preoperative chemoradiation for rectal cancer. However, large randomized trials with comparative methodologies are needed.
Identification of a Novel Cell-Penetrating Peptide from Human Phosphatidate Phosphatase LPIN3
최제민,임상호,김원주,Yeon-ho Kim 한국분자세포생물학회 2012 Molecules and cells Vol.34 No.6
Biomolecules such as proteins, DNA, and RNA are mac-romolecules and can not cross the cell membrane. How-ever, cell-penetrating peptide (CPP) has been shown to deliver therapeutic biomolecules successfully into cells. The various and widely used CPPs including TAT, VP22, and Antp are mostly non-human originated CPPs, and are limited by their potential toxicity and immunogenicity. We report here on a newly identified novel cell-penetrating sequence (LPIN; RRKRRRRRK) from the nuclear localization sequence (NLS) of human nuclear phosphatase, LPIN3. LPIN-EGFP recombinant protein was concentration- and time-dependently delivered into cells and localized to the nucleus as well as the cytoplasm. It penetrated the cell membrane by lipid raft-mediated endocytosis by binding to heparan sulfate proteoglycan. LPIN-EGFP was successfully delivered into primary mouse splenocytes in vitro and it could be delivered into various tissues including liver, kidney, and intestine in mice after intra-peritoneal injection. This re-search suggests that LPIN-CPP could be used in a drug delivery system to deliver therapeutic biomolecules including peptides, proteins, DNA, and RNA and without the limitations of non-human originated CPPs such as TAT-CPP.
Hematochezia due to Angiodysplasia of the Appendix
최제민,이승훈,이승현,안병권,백승언 대한대장항문학회 2016 Annals of Coloproctolgy Vol.32 No.3
Common causes of lower gastrointestinal bleeding include diverticular disease, vascular disease, inflammatory bowel disease, neoplasms, and hemorrhoids. Lower gastrointestinal bleeding of appendiceal origin is extremely rare. We report a case of lower gastrointestinal bleeding due to angiodysplasia of the appendix. A 72-year-old man presented with hematochezia. Colonoscopy showed active bleeding from the orifice of the appendix. We performed a laparoscopic appendectomy. Microscopically, dilated veins were found at the submucosal layer of the appendix. The patient was discharged uneventfully. Although lower gastrointestinal bleeding of appendiceal origin is very rare, clinicians should consider it during differential diagnosis.
The Nuclear Receptor PPARs as Important Regulators of T-Cell Functions and Autoimmune Diseases
최제민,Alfred Bothwell 한국분자세포생물학회 2012 Molecules and cells Vol.33 No.3
Members of the nuclear receptor superfamily function as transcription factors involved in innate and adaptive im-munity as well as lipid metabolism. These highly conser-ved proteins participate in ligand-dependent or -indepen-dent regulatory mechanisms that affect gene expression. Peroxisome proliferator-activated receptors (PPARs), which include PPAR, PPAR/, and PPAR, are a group of nuclear receptor proteins that play diverse roles in cellular differentiation, development, and metabolism. Each PPAR subfamily is activated by different endogenous and synthetic ligands. Recent studies using specific ligand treatments and cell type-specific PPAR knockout mice have revealed important roles for these proteins in T-cell-related autoimmune diseases. Moreover, PPARs have been shown to regulate T-cell survival, activation, and CD4+ T helper cell differentiation into the Th1, Th2, Th17, and Treg lineages. Here, we review the studies that provide insight into the important regulatory roles of PPARs in T-cell activation, survival, proliferation, differentiation, and autoimmune disease.
글로벌 금융위기 이후 한국의 소득불평등 변화에 관한 연구
최제민 ( Jemin Choi ),김성현 ( Sunghyun Kim ),박상연 ( Sangyeon Park ) 한국경제학회 2018 經濟學硏究 Vol.66 No.1
본 연구는 한국노동패널조사를 사용하여 1997-2014년 한국의 소득불평등 추이를 분석하고 지니계수 소득원천별 분해 분석을 통해 지니계수의 추이 변화 원인을 분석한다. 가계동향조사를 통해 구한 통계청의 공식 지니계수가 금융위기 이후 꾸준히 하락 (소득 불평등 개선)함과는 달리, 노동패널조사를 통해 계산한 지니계수는 금융위기 이후 감소하는 추이를 보이다가 2012년과 2013년에는 오히려 증가하였고 소득불평등 수준 또한 OECD 국가 중에서 8번째로 높은 것으로 나타났다. 지니계수 소득원천별 분해 분석결과, 금융위기 이후 불평등이 개선되는 추이를 보이는 원인은 고소득층의 부동산소득과 금융소득 감소로 인한 전체 불평등 악화효과 감소, 그리고 저소득층에 대한 이전소득과 사회보험소득의 불평등 개선효과 증가가 주원인인 것으로 나타났다. 그러나 가구 전체소득의 가장 큰 부분을 차지하는 근로소득의 경우, 금융위기 이전과는 달리 금융위기 이후 불평등 정도가 크게 확대되었고 전체 소득불평등에 미치는 영향도 증가하였다. 따라서 금융 위기 이후 지니계수 감소현상을 긍정적으로 해석하기 어려운 것으로 판단된다. This paper calculates Gini coefficient using the KLIPS (Korean Labor & Income Panel Study) data to evaluate how income inequality has changed in Korea during 1997-2014. We decompose the Gini coefficient by its income sources to examine marginal effects from different income sources. Unlike the official Gini coefficient based on the HIES (Household Income and Expenditure Survey) which has been continuously declining (improvement of inequality) since the global financial crisis, the newly calculated Gini coefficient has declined and then increased during 2012-13. Korea is ranked 8th in income inequality among OECD countries in this new statistic. Gini coefficient decomposition by its income source shows that the decline in income inequality is due to a smaller negative impact of real estate and financial income and a larger positive effect from transfer income and social security income on improving income inequality. However, labor income’s marginal effect on the Gini coefficient has changed from negative to positive over the global financial crisis period, which has contribute to the increase in income inequality. Therefore, the decline in Gini coefficient after the financial crisis does not necessarily mean an improvement in perceived income inequality.