Silymarin과 작약감초탕 병용투여의 C57BL/6 마우스 간조직 지질축적 및 염증 억제효과

최정원,조수정,신미래,박해진,Choi, Jeong Won,Cho, Su-Jung,Shin, Mi-rae,Park, Hae-Jin 대한본초학회 2022 大韓本草學會誌 Vol.37 No.5

Objective : The aim of the present study is to examine hepatic lipid-lowering and anti-inflammatory effects of silymarin combined with Jakyakgamcho-tang on non-alcoholic fatty liver disease in a high fat diet-induced obese mice model. Methods : C57BL/6 mice were divided into four dietary groups: (1) Normal, (2) Control (60% high-fat diet), (3) Control + silymarin 50 mg/kg/day (Silymarin), (4) Control + Silymarin 50 mg/kg/day + Jakyakgamcho-tang 100 mg/kg/day (SPG). After 12 weeks administration, mice were sacrificed and lipids and inflammation-related biomarkers were analyzed liver and plasma. Results : Silymarin and SPG treatments significantly lowered body and liver weights compared to the Control. Serumlipids (triglyceride (TG), total cholesterol) and pro-inflammatory cytokines (tumor necrosis factor alpha, interleukin 1𝛽, and IL-6) concentrations were significantly lowered in the Silymarin and SPG groups than the Control group. Silymarin and SPG treatments suppressed hepatic TG level and hepatic lipid droplets compared to the Control. Theses two treatments significantly increased hepatic kinase B1 and AMP-activated protein kinase protein levels, and significantly decreased hepatic key lipogenic enzymes (acetyl-CoA carboxylase, fatty acid synthase and stearyl coenzyme A desaturase 1) protein levels than the Control. SPG also significantly increased hepatic fatty acid oxidation-related protein (peroxisome proliferator-activated receptor alpha and uncoupling protein 2) levels than the Control. Conclusions: Silymarin and SPG suppressed hepatic lipid accumulation by regulating hepatic protein expression, and lowered blood pro-inflammatory cytokines concentrations though the synergic effect of silymarin and Jakyakgamchotang was not clear.

생명과학기술 관련 교육 프로그램이 중학생의 과학기술에 대한 흥미, 태도 및 진로 인식에 미치는 효과

최정원 ( Jung Won Choi ),한화정 ( Hwa-jung Han ),심규철 ( Kew-cheol Shim ) 한국생물교육학회 2021 생물교육 Vol.49 No.4

The purpose of this study was to develop the educational program related to biological technology for middle school students, and to investigate their interests in scientific technology, scientific technology-related attitudes and career perception. Relating to biological technology, three themes were developed: Artificial intelligence(AI), emotional robot, and virus. To this end, learning contents of scientific technology and human civilization unit were reorganized to 3 theme(artificial intelligence, emotional robot, and virus) related to biological technology. The educational program related to biological technology consisted of totally 6 lesson hours. The program had 3 phases of drawing thoughts, connecting with me, and connecting with career. Subjects were 122 ninth graders(61 in control group, 61 in treatment group), who were middle school students in Chungnam province. In order to investigate the effects of the program, the post test of their interests in scientific technology, scientific technology-related attitudes and career perception were conducted. As a result of the educational program related to biological technology, the program effected positively on the interests in scientific technology, scientific technology-related attitudes and career perception of middle school students. It implied that the educational program related to biological technology need to be actively used for science education.

선학초 (짚신나물) 복강주사의 항암효과 탐색 및 약물 대사효소의 변화

최정원(Jung-Won Choi),장보형(Bo-Hyung Jang),이주아(Ju-Ah Lee),고호연(Ho-Yeon Ko),정희(Hee Jung),전찬용(Chan-Yong Jun),박종형(Jong-Hyung Park),김지혜(Ji-Hye Kim),고성규(Seong-Gyu Ko),최유경(You-Kyung Choi) 대한한의학회 2009 대한한의학회지 Vol.30 No.4

거주자 평가(POE)를 통한 아파트 주호 실내 계획에 관한 연구

최정원(Choi, Jung-Won),제해성(Je, Hae-Seong),하미경(Ha, Mi-Kyoung),이효창(Lee, Hyo-Chang) 한국실내디자인학회 2006 한국실내디자인학회논문집 Vol.15 No.6

산업진흥교육 : 공적 사회복지 전달체계에 나타난 조직운영 상의 실태분석을 통한 극복요인 연구

최정원 ( Jung Won Choi ),김보기 ( Bo Ki Kim ) 산업진흥원 2016 산업진흥연구 Vol.1 No.1

본 연구는 사회복지의 발전추세에 따라 향후 공적 사회복지 전달체계가 더욱 중요함을 인식하고 여기에 나타난 조직운영 상의 실태분석을 통해 극복요인을 파악하고자 하였다. 극복요인으로는, 첫째, 전달체계의 속성에 대한 극복이다. 둘째, 업무의 비효율성에 대한 극복이다. 셋째, 전달체계 및 인력상의 부조화에 대한 극복이다. 넷째, 사회복지통합관리망의 관리부실에 대한 극복이다. 결론적으로 본 연구를 통해 위와 같은 극복요인이 해결될 때 비로소공적 사회복지 전달체계가 원활히 이루어질 수 있음을 알 수 있다. This study recognized public social welfare delivery system will be more important in the future according to the developing trend of social welfare that and intended to find overcome factors by analyzing actual status of operating organization. The study results showed that characteristics of delivery system, ineffectiveness of task, delivery system and inconcinnity of personnel are the overcome factors of social welfare. Consequently, this study revealed that public social welfare delivery system will go on smoothly at last when the problems of the overcome factors get solved.

정신장애를 가진 부모의 자녀(Children of Parents with a Mental Illness, COPMI)에 대한 설명 모델과 심리사회적 개입에 대한 고찰

최정원 ( Jung Won Choi ) 한국정신병리진단분류학회 2020 精神病理學 Vol.24 No.1

This review provides the mechanism of transgenerational transmission of mental disorder (TTMD), the factors involved in them, and the psychosocial interventions in the Children of Parents with a Mental Illness (COPMI). The TTMD is a combination of biological risk factors and various psychological risk factors including parent-related factors, family condition, child-related factors and social-environmental factors. Interventions in the COPMI consist of peer support programs, parent education, family intervention, professional education, and community networking. Evidence on the effectiveness of intervention programs is accumulating. Policies and researches are needed to strengthen medical and social support in Korea to reduce social losses from TTMD.

광범위한 뇌연수막 파종으로 나타난 역형성 성상세포종의 특이 발현 Temozolomide를 기초로 치료한 두 증례 보고

최정원 ( Jung Won Choi ),김인아 ( In A Kim ),최기영 ( Ghee Young Choe ),김재용 ( Chae Yong Kim ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2008 대한뇌종양학회지 Vol.7 No.2

We describe two unusual cases of diffuse leptomeningeal seeding as the initial manifestation of a subtle brain mass lesion. At first, they were misdiagnosed as tuberculous encephalitis because there was no obvious mass lesion in magnetic resonance(MR) images of the brain and the cerebrospinal fluid profile was highly suggestive of an infective process. The MR images showed only ill-defined lesions in the basal ganglia. Anaplastic astrocytomas were finally diagnosed following stereotactic brain biopsies. Whole-spine MR images from these two patients revealed diffuse leptomeningeal enhancing lesions that affected the whole spine. We planned aggressive multimodal treatment including concurrent chemoradiation therapy using temozolomide. One patient died from disease progression eight months after the initial diagnosis. The second patient was treated more aggressively. She survived for more than thirteen months after diagnosis. Biopsy and aggressive treatment must be considered in cases of ill-defined lesions with clinical manifestation indicating unusual encephalitis.

과학관 서비스 품질이 고객만족도 및 재방문 의도에 미치는 영향 분석

최정원(Choi, Jung won),남태우(Nam, Tae woo),조재민(Cho, Jae min) 한국전시산업융합연구원 2017 한국과학예술융합학회 Vol.27 No.-

우리나라의 과학관수는 2008년 72개에서 2016년 128개로 양적 팽창을 이루었다. 본 연구는 많은 예산을 투입하여 과학관을 건립하지만, 하루 평균 관람객 수가 50명 이하의 과학관이 1/4 이상으로 비효율적인 기관이 많다는 점에서 시작되었다. 과학관 운영의 효율성을 높이기 위해 관람객 수는 중요한 요소이다. 본 연구의 목적은 과학관 서비스 품질과 고객만족도 및 재방문 의도와의 관계를 분석하여, 더 많은 관람객을 유인하기 위해 과학관에서는 어떠한 노력을 집중해야 하는지 알아보는 것이다. 국립과천과학관의 전시, 교육, 문화 분야로 각각 설문지를 작성하여 서비스 접점별 고객을 대상으로 설문조사를 실시하였다. 그 결과를 빈도분석, 신뢰도 분석, 요인분석, 다중회귀분석 등으로 도출하였다. 연구결과 및 내용은 다음과 같다. 첫째, 전시분야에서 전시 시설물에 대한 품질은 고객만족도 및 재방문 의도에 영향을 미칠 것으로 예상했지만 유의미한 관계를 얻지 못했다. 둘째, 교육분야는 서비스 품질(운영 및 내용, 강사, 교육시설 및 환경) 모든 요소에서 고객 만족도와 재방문 의도에 영향을 미치는 것으로 결과가 도출되었다. 셋째, 문화(행사)분야에서는 문화프로그램의 질이 관람객 만족도에 영향을 미치지만 재방문 의도에는 영향을 미치지 않는 것으로 나타났다. 과학관은 과학과 예술 등의 융복합 활동이 이루어져 관람객에게 만족을 줄 수 있다. 결과를 바탕으로 향후 국립과학관 전체에 대한 융복합 연구가 진행되어 관람객 만족도와 재방문을 높일 수 있도록 노력이 필요하다. The number of science museums in Korea has expanded quantitatively from 72 in 2008 to 128 in 2016. This study started with the fact that the government puts a lot of budget into building a science museum, but there are more than one quarter of science museums with less than 50 spectators per day and many inefficient institutions. The number of visitors is an important factor in improving the efficiency of the science museum operation. The purpose of this study is to analyze the relation between the service quality of the science museum and the customer satisfaction and the intention to revisit and to find out what kind of effort should be concentrated in the science museum to attract more visitors. Questionnaires were written in the exhibition, education, and culture fields of the Gwacheon National Science Museum. The results were derived by frequency analysis, reliability analysis, factor analysis, and multiple regression analysis. The results and contents of the study are as follows. First, in the field of exhibition, the quality of exhibition facilities was expected to affect customer satisfaction and intention to return, but did not have a meaningful relationship. Second, the education sector has been found to affect customer satisfaction and return intention in all aspects of service quality (operation and contents, instructors, educational facilities and environment). Third, in the field of culture (event), the quality of the cultural program influences the visitor satisfaction, but it does not affect the intention to revisit. The science museum can provide satisfaction to visitors by combining activities such as science and arts. Despite the limitations, it is necessary to make efforts to improve the visitor satisfaction and revisit by proceeding with the convergence research on the entire National Science Museum in the future.

초등학생 대상의 MBSR에 기반한 명상프로그램이 자아존중감과 학교부적응에 미치는 효과

최정원(Jung-Won Choi) 한국명상학회 2018 한국명상학회지 Vol.8 No.1

이 연구는 초등학생의 자아존중감을 향상시키고 학교부적응 행동을 줄이기 위해 MBSR을 기 반으로 하는 명상프로그램을 초등학생의 수준에 적절하게 재구성하여 그 효과를 검증하는 데 있다. 명상프로그램은 마음챙김의 하위 구성개념(현재자각, 주의집중, 비판단적 수용, 탈중심 적 주의)을 기반으로 프로그램의 단계를 구성하였다. 초등학생이 수행하기에 적합하도록 다 양한 명상기법을 도입하였고, 자아존중감과 학교부적응의 구성요소를 포함한 활동을 도입한 프로그램이라는 점에서 기존의 명상만을 위주로 하는 성인용 명상프로그램이나 명상의 일부 분만을 적용하는 집단프로그램과는 다르다. 연구는 G시에 소재한 A초등학교 6학년이면서 프 로그램 참여에 동의 한 7명을 실험 집단으로 선정하였다. 통제집단은 동일한 학년의 학생들 중 7명을 무선 선별하였다. 프로그램은 주 1회, 50분간, 총 10회기를 실시하였다. 연구결과는 다음과 같다. 첫째, 실험집단은 통제집단에 비해 자아존중감이 통계적으로 의미있게 향상되었 다. 둘째, 실험집단은 통제집단에 비해 학교부적응 행동이 통계적으로 유의미하게 낮아졌다. 이 연구는 MBSR에 기반한 명상프로그램을 초등학생의 수준에 적합하게 구성하여 학교부적응 을 보이는 초등학생의 문제 개선을 위한 교육프로그램으로 학교 현장에서 활용할 수 있다는 점에서 의의가 있다. The purpose of this study is to validate the effects of a Mediation Program based on MBSR by properly reconfiguring program to the level of elementary school students to improve self-esteem and to reduce maladjusted behavior of elementary school students. The Mediation Program steps of the program based on the substruction of Mindfulness (current awareness, attention, non-judging acceptance, decentered awareness). The program used various meditation techniques to make it suitable for elementary school children to practice. This Mindfulness Mediation program is different from an adult meditation program that focuses only on traditional meditation or a group of programs that apply part of meditation because it introduces activities that include components of self-respect and maladaptation. The subjects for this study were 14 sixth-grade students of A elementary school in Gwangju Metropolitan City, Korea. The students were divided into two groups; seven people who agreed to participate in the program were selected as experiment groups and the other is a control group of 7 applicants which didn’t have any treatments. The program was held once a week for 50 minutes, for a total of 10 sessions. The findings of the study are as follows. First, the self-esteem of the experiment group improved over that of the control group. Second, the Maladjustment Behavior in School of the experimental group decreased compared to that of the control group. This study is significant as it can be used in schools as an educational program to improve problems for school-maladjusted elementary school students through an MBSR-based meditation program that is tailored to their level.

장애인 임금근로자의 자기효능감, 행복, 직무만족도 사이의 매개효과와 장애로 인한 업무 지장의 조절된 매개효과

최정원(Choi, Jeong won),오현정(Oh, Hyun jung),홍세희(Hong, Se hee) 한국직업재활학회 2020 職業再活硏究 Vol.30 No.2

The purposes of this study were to examine the mediating effect of job satisfaction and the moderated mediating effect of work interference due to disabilities on the relationship between self-efficacy and happiness among workers with disabilities. For the study, the data of 1,622 workers with disabilities who participated in the 3rd survey of 2nd wave in the Panel Survey of Employment for the Disabled (PSED) was analyzed using Mediation analysis and Moderated-Mediation analysis with SPSS Process Macro. The results can be summarized as follows. First, job satisfaction mediated the relationship between self-efficacy and happiness. Second, the indirect effect of self-efficacy through job satisfaction on happiness was moderated by work interference due to disabilities. This study is meaningful in that it provided theoretical foundation regarding the intervention and policy of workers with disabilities. 본 연구는 장애인 임금근로자의 자기효능감이 행복에 미치는 영향에서 직무만족도의 매개효과를 검증하고, 자기효능감, 직무만족도, 행복의 관계에서 장애로 인한 업무 지장의 조절된 매개효과를 검증하는 것을 목적으로 한다. 이를 위해 장애인고용패널조사 2차 웨이브의 3차 조사 자료를 활용하였으며, SPSS Process Macro로 매개효과와 조절된 매개효과를 검증하였다. 연구결과를 정리하면 다음과 같다. 첫째, 장애인 임금근로자의 자기효능감이 행복에 유의한 영향을 미치고 이 관계를 직무만족도가 매개하는 것으로 나타났다. 둘째, 자기효능감이 직무만족도를 통해 행복에 미치는 간접효과는 장애로 인한 업무 지장에 의해 조절되는 것으로 나타났다. 본 연구는 장애인 임금근로자의 자기효능감과 행복의 관계 사이에서 직무만족도의 역할을 확인함으로써 장애인 고용을 복지의 측면에서 분석했다는 점에서 의미가 있고, 장애인 고용의 질을 높이기 위해 장애인이 일하는 과정에서 장애로 인해 겪을 수 있는 환경적, 업무 내용적 어려움을 중심으로 접근할 필요성을 제시함으로써 정책 개입을 위한 이론적 토대를 마련했다는 점에서 의의가 있다.