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- 저자 : 최정욱 ( Choe Jeong Ug ) (검색결과 4 건)
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Efficient PDE-based Segmentation Algorithms and Their Application to CT Images
최정욱 ( Choe Jeong Ug ),김귀연 ( Kim Gwi Yeon ),박범 ( Park Beom ),왕지남 ( Wang Ji Nam ),김성재 ( Kim Seong Jae ) 대한설비관리학회 2003 대한설비관리학회지 Vol.8 No.3
N/A This article is concerned with efficient and reliable segmentation algorithms in particular for CT-scan images. A level set formulation is considered for the Mumford-Shah minimization in segmentation; the corresponding partial differential equations (PDES) are solved by the backward Euler discretization. For a better convergence of active contours (snakes), we suggest two of new strategic s : an image-dependent initialization and the imposition of upper liits for the level set function. Furthermore, the altemating direction implicit (ADI) method is applied for an efficient time integration. The resulting algorithm, Euler-ADI, along with the new &-up techniques, has proved to locate segmentation in 2-4 iterations accurately unless the edges in the image show missing portions a lot.
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혈전성 양측 신동맥 폐쇄로 인한 급성 신부전증 환자에서의 성공적인 스텐트 삽입술
최정욱 ( Choe Jeong Ug ),김장영 ( Kim Jang Yeong ),이승환 ( Lee Seung Hwan ),유종명 ( Yu Jong Myeong ),한병근 ( Han Byeong Geun ),최승옥 ( Choe Seung Og ) 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.3
Renal artery disease is one of the significant factors that lead to compromise renal function and/or aggravate hypertension in the elderly population. Since the non-surgical treatment of renal artery stenosis,percutaneous transluminal renal angioplasty, is available, it is possible to cure the decreased renal function and exacerbated hypertension. However, bilateral renal artery occlusion (BRAO) that brings about anuria and azotemia is rare. In this communication, we`d like to describe a patient who developed acute renal failure due to BRAO. His renal function was completely recovered after successful implantation of stents into both renal arteries. We are unaware of prior reports documenting the beneficial effect of a distal embolic protection device, the Percu-Surge GuardWire system (Medtronic, Minneapolis, MN, USA), in a clinical setting as described here. The GuardWire arm, a device for transient distal balloon occlusion during angioplasty or stent placement, allows recovery of any liberated plaque by aspiration before restoration of antegrade flow, and thereby performs a double service. We`d like to strongly recommend that stent implantation with adjunctive distal protection is essential to obtain a complete restoration of distal blood flow although there is sufficient collateral blood flow in elderly patients with BRAO and azotemia.
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대사증후군과 자가 면역성 갑상선염을 동반한 Turner 증후군
최정욱 ( Choe Jeong Ug ),변종원 ( Byeon Jong Won ),이연 ( Lee Yeon ),심명숙 ( Sim Myeong Sug ),신영구 ( Sin Yeong Gu ),정춘희 ( Jeong Chun Hui ) 대한내과학회 2003 대한내과학회지 증례 특집호 65-5 부록3 Vol.0 No.-
Autoimmune thyroiditis in Turner syndrome is more prevalent in women with the X isochromosome karyotype, compared with other karyotypes. The cause of obesity in Turner syndrome is not to be sure, it may be related to metabolic syndrome inducing insulin re
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허혈-재관류 신손상 백서에서 Cyclosporin A와 Mycophenolate Mofetil이 TGF-β1 및 Endothelin-1의 발현에 미치는 영향
한병근 ( Han Byeong Geun ),송기학 ( Song Gi Hag ),이재명 ( Lee Jae Myeong ),양재원 ( Yang Jae Won ),최정욱 ( Choe Jeong Ug ),김정권 ( Kim Jeong Gwon ),최승옥 ( Choe Seung Og ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.3
목 적 : 현재 가장 널리 사용되는 면역억제제 중의 하나인 Cyclosporin A (CsA)가 신이식의 성적을 향상시켰으나 신독성으로 인해 이식신의 장기적인 생존율에는 영향을 미치지 못하고 있다. CsA에 의해 생성이 증가된 Transforming growth factor-β (TGF-β)와 Endothelin-1 (ET-1)이 주요한 신독성의 매개인자로 밝혀졌다. 최근 Azathioprine 대용으로 Mycophenolate mofetil (MMF)이 널리 사용되어 CsA와 MMF를 병합투여 시 면역억제기능이 상승하지만 CsA의 신독성을 매개하는 인자에 대한 연구는 없다. 이에 본 연구에서는 허혈-재관류 모델 백서에서 CsA와 MMF를 단독 또는 병합투여 시 CsA 신독성의 중요한 매개인자인 TGF-β1과 ET-1의 생성과 발현에 어떤 영향을 미치는지 알아보고자 하였다. 방 법 : 단일 신장 백서의 혈관경 (renal pedicle)을 30분간 클램프한 후 재관류하여 허혈-재관류 손상을 유발시켜 대조군, 허혈-재관류군, CsA 투여군, CsA와 MMF 병합투여군, MMF 투여군으로 나누어 매개물질의 합성 및 발현을 면역조직화학염색, 역전사 중합효소연쇄반응 및 공초점레이져주사현미경 (confocal microscope)으로 측정하였다. 결 과 : CsA를 사용한 군에서 세뇨관의 공포 형성과 같은 조직학적 손상이 나타나 CsA에 의한 신독성을 간접적으로 확인할 수 있었다. TGF-β1은 주로 세뇨관에서 발현이 되고 ET-1은 혈관의 내피세포와 보우만씨 소체에서 주로 발현되었다. TGF-β1의 발현은 CsA 투여군에서 면역조직화학염색과 공초점레이져주사현미경 검사상 대조군과 다른 실험군에 비해 증가되었다. ET-1의 발현은 CsA 투여군에서 면역조직화학염색, mRNA 및 공초점레이져주사현미경 검사상 대조군과 다른 실험군에 비해 발현이 증가되었다. TGF-β1과 ET-1의 발현은 병합요법군이 CsA 투여군보다 감소되었다. MMF 투여군에서의 TGF-β1과 ET-1의 발현은 허혈-재관류군과 비슷한 양상을 보였으며, CsA군과 병합요법군보다 낮은 발현율을 보였다. 결 론 : 허혈-재관류 신손상 시 MMF는 CsA와는 다르게 TGF-β1이나 ET-1의 발현을 증가시키지 않으며 특히 CsA와 병합투여 시 CsA 단독투여 시 보다 유의하게 TGF-β1과 ET-1의 발현을 감소시키는 것으로 보아 CsA와 MMF의 병합요법은 장기이식 환자에서 CsA 치료의 아킬레스건인 신독성을 줄일 수 있을 것으로 생각된다. Purpose: Nephrotoxicity of cyclosporin A (CsA) remains a major obstacle for the clinical use of this potent immunosuppressant. It is likely that the transforming growth factor-β (TGF-β) and endothelin-1 (ET-1)play a central role in initiation and/or progression of CsA induced nephropathy in renal is-chemia-reperfusion injury. It is proposed that the new immunosuppressive drug mycophenolate mofetil (MMF) reduces the incidence of acute rejection in comparison with azathioprine. Thus, the aim of the present study was to analyze the wxpression of TGF-β and ET-1 in renal ischemia-reperfusion in jured rats and to see the effect of CsA or MMF on the expression of these mediators. Effects of coad ministration of CsA and MMF were also evaluated. Methods: Sprague-Dawley rats (N=60) performed right nephrectomy were classified into five groups according to experimental methods. Control group underwent right nephrectomy. After the right nephrectomy, to induce renal ischemia, the left renal vascular pecicle was occluded for 30 minutes with vascular pedicle was occluded for 30 minutes with vascular clamps in all experimental groups. After 30 minutes, the clamps were removed to undergo reperfusion. In control groupl. ischemic injury wasn`t done. CsA group was administered CsA (10mg/kg/day, S.C) after the operation. CsA and MMF group was coadministered CsA (10mg/kg/day, S.C) and MMF (10mg/kg/day, P.O). MMF group was administered MMF (10mg/kg/day, P.O). After 7 days, the left kidney was removed and processed for histological, immunohistochernical, immunofluorescent and molecular analyses for TGF-β1 and histological, immunohistochemical, immunofluorescent analyses for ET-1. Results: The immunohistochemical and immunofluorescent expression density for TGF-β-1 in CsA group was higher than control and other experimental groups. The immunohistochemical and immunofluorescent expression density and mRNA production for ET-1 in CsA group was higher than control and other experimental groups. The expression density for TGF-β-1 and ET-1 CsA group. The expression density for TGF-β-1 and ET-1 in MMF group was less than in CsA group and CsA and MMF group, was similar to ischemia-reperfusion group. Conclusion: These results suggest that MMF does not seem to have effect from CsA in seems to have a reno-protective effect from CsA induced nephrotoxicity in the ischemia-reperfusion model. The present study might partially explain that MMF is going to contribute to the improvement of the survival rate of the transplanted kidney associated with acute and/or chronic rejection and to the reduction of CsA dosage and its complications. (Korean J Nephrol 2003;22(3):273-284)
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