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사상체질유형과 ACE(angiotensin converting enzyme) 유전자 Type(polymorphism)과의 상관관계
최승훈,임용빈,이준우,김홍열,강철훈,Choi, S.H.,Yim, Y.B.,Rhee, J.W.,Kim, H.Y.,Kang, C.H. 사상체질의학회 1998 사상체질의학회지 Vol.10 No.2
Sasang Constitutional Medicine focuses on the different constitutional manifestations of the individual's nature and emotions. The nature and emotions drive the ascending and descending of Qi in the body. And this dynamics of the Qi's ascent and descent shapes the different types of structures, functions and temperaments. Although Sasang Constitutional Medicine has many advantages, its diagnosis of the constitution still depends on the doctors' own idea and has no objective identification. So many doctors in Korea have been trying to solve this problem. Recently, there are several efforts to find out the relationship between genetic information and constitution. By the way, May, 1998 there is a astonishing report about the gene which determines the human performance, that is ACE(angiotensin converting enzyme). And it suggests that the I allele was associated with improved endurance performance. ACE has three genotype including II, ID and DD. "I" means insertion and "D" means deletion. We determined the type of the Sasang constitution with QSCCII questionaire and the one's ACE genotype with PCR of the 127 people and we discovered the relationship between the constitution and the ACE genotype. The result is as follow. Among 39 people who have the II genotype, 7(18%) belong to Taeum(Taiyin), 9(23.1%) belong to Soyang(Shaoyang) and 23(59%) belong to Soeum(Shaoyin). Among 62 people who have the ID genotype, 18(29%) belong to Taeum(Taiyin), 21(33.9%) belong to Soyang(Shaoyang) and 23(37.1%) belong to Soeum(Shaoyin). Among 26 people who have DD genotype, 11(42.3%) belong to Taeum(Taiyin), 4(15.4%) belong to Soyang(Shaoyang) and 11(42.3%) belong to Soeum(Shaoyin). This data indicates that there are implicable relationship between the Sasang constitution and ACE genotype. Especially people who have II genotype have much possibility to be a Soeum(Shaoyin) person (59%) and Soyang(Shaoyang) person have less possibility to have DD genotype (15.4%). With this conclusion, we suggest further study of relationship between the Sasang constitution and ACE genotype and we think that other polymorphism can be a candidate of the partner of Sasang constitution.
고 - 기 화학열변환기의 최적설계 및 성능해석에 관한 연구
최승훈,이세일,백일현,최익수 ( S . H . Choi,S . I . Lee,I . H . Baek,I . S . Choi ) 한국공업화학회 1997 공업화학 Vol.8 No.5
산업폐열을 활용하기 위해 금속염화물-암모니아계 화학열변환기를 설계하고 IkW-1hr 용량의 장치개발을 하였다. 이는 170℃ 열원을 210℃ 이상으로 승온시키는 화학열펌프 시스템으로서, 효율적인 화학반응기의 설계를 위하여 필요한 반응물의 양과 반응물의 조건 등을 산출하는 정적계산과 동적모사를 수행하였다. 모사결과 열교환면적이나 반응기내 염의 양 등의 변수에 따라 시스템의 온도와 출력이 변함을 알 수 있었고 또한 반응물질의 양과 겉보기밀도 및 장치구조의 영향을 고찰하고 최적조건을 결정할 수 있었다. 4단계 작동사이클에 따라 운전한 결과 온도 및 출력의 실험치는 모사치와 비교하여 양호한 결과를 얻었으며 이 화학열변환기는 일정온도로 승온시킬 수 있는 특징으로 인해 앞으로 산업공정에서 배출되는 폐열원을 활용할 수 있는 시스템으로서의 가능성을 확인하였다. For the recovery of industrial waste heat, a chemical heat transformer based on the reversible reactions between metal chlorides and ammonia gas was designed and a pilot scale unit of 1 kW-1hr was developed. A static calculation, which determined the amount of reacting materials and operating condition of system, and dynamic simulations were performed for the optimal design. The temperature and output power of generator in the system were varying with the amount of salt and heat exchange area. Optimum conditions such as the amount of salt-graphite, apparent density and size of mechanical unit were determined by the dynamic simulation for the system. According to the operating cycle of 4 stages, experimental results of temperature and output power were well agreed with the simulation values. This chemical heat transformer is turned out to be a very promising system for recovery of industrial waste heat because of its effective feature of lifting temperature.
Interleukin - 2 와 Cycolphosphamide 를 이용한 말기암 환자 치료
최승훈(S H Choi),임태숙(T S Lim),김병로(B R Kim),박기일(K L Park),이경식(K D Lee),함경수(K S Hahm),나도선(D S Na),한문희(M H Han) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.4
N/A Application of adoptive immunotherapy has been the inability to generate specifically sensitized lymphoid cells with antitumor reactivity. Interleukin-2 is now available in large quantities and has made possible expansion of cells with a diverse spectrum of immune reactivities. In this study, we evaluated the immunologic effects and the response rate of LAK cell, Interleukin-2 and cyclophosphamide administered intravenously in humans with tumors unresponsive to other treatments. There were five hepatomas and a metastatic breast cnacer. Two patients received LAK cell and Interleukin-2 twice. 5.94x10 monounclear cells were obtained in each leukapheresis. Cellular cytotoxicity was measured using 51 Chromium release assay. This study clearly showed that Interleukin-2 and Cyclophosphamide treatment augmented LAK cell activity, but there were no statistically significant differences in the natural killer cell function after the treatment. There were one complete response and one partial response. It could be speculated that LAK, Interleukin-2 and Cyclophosphamide therapy can be used as an adjuvant treatment for the advanced cancer.
다발성소아손상환자에서 소아외상치와 손상정도치의 비교 평가
최승훈 ( S. H. Choi ),조영업 ( Y. U. Cho ),지훈상 ( H. S. Chi ),이희대 ( H. D. Lee ),김병로 ( B. R. Kim ),황의호 ( E. H. Hwang ),이한식 ( H. S. Lee ) 대한외상학회 1988 大韓外傷學會誌 Vol.1 No.2
Trauma is one of the most common causes of death in children. Recently, injury severity score (ISS) is widely used to evaluate and classify the patients with multiple injury. Pediatric trauma score (PTS) was developed as a means of providing rapid accurate assessment of the injured child. We analyzed the records of 130 consecutive trauma patients admitted to the Yonsei University Hospital from January, 1977 to December. 1986. PTS and ISS were collected from comprehensive initial evaluation. There were 8 persons who did following hospital admission. The most common cause of injury was motor vehicle accident (56.9 %) followed by falling down injury (24.1 ). This study demonstrated the inverse linear relationship between the PTS and f55. Patients with a PT5 of 8 and below have an increased potential for mortality as well as morbidity. Likewise, the patients with a ISS of 2 and above have a same tendency. The ISS was developed that correlates well with survival and provides a numerical description of the overall severity of injury for patients with multiple trauma. The PTS is simplified classify-cation system for pediatric age group. Use of the ISS or PTS facilitates comparison of the mortality experience of varied group of trauma patients.