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Preparation of the Monoclonal Antibodies against the Zppspores of Allomyces macrogynus
최소영,황정숙,김정섭,박경희,조정원,윤현주,Choi, So-Young,Hwang, Jung-Sook,Kim, Jung-Seoup,Park, Kyung-Hee,Cho, Chung-Won,Youn, Hyun-Joo 한국생명과학회 1996 생명과학회지 Vol.6 No.4
Allomyces macrogynus의 유주자에 대한 단일클론항에를 만들었다. 고정된 유주자를 주사하거나 유주자 단백질 용액을 주사함으로서 생쥐를 면역화 하였으며, 하이브리도마 세포들은 효소면역흡착법을 이용하여 검색하였다. 약 30개의 하이브리도마 클론이 유주자에 대한 항체를 생산하는 것으로 확인 되었으며, 이들중 일부는 단일세포클론으로 분리되었다. 이들이 만들어내는 항체는 정제되어, 간법면역형광법에 의하여 유주자의 표면에 반응하는 항체로 확인되었다. 또한, 하이브리도마 배양상등액을 이용하여 유주자의 성장에 영향을 미칠 수 있는 클론을 조사하여 보았다. 조사한 배양5상등액중 두가지의 하이브리도마에서 얻은 배양상등액이 germ tube 의 성정을 촉진하는 것으로 확인되었다. Monoclonal antibodies against the zoospores of Allomyces macrogynus were prepared using standard hybridoma technique. Mice were immunized either with the fixed zoospores or the zoospore proteins, and the production of the antibodies from the resulting hybridomas were screened by enzyme-linked immunosorbent assay (ELISA). Thirty hybridomas were initially identified ans six hybridomas were purified to the single cell clones. Culture supernatants from the hybridomas were tested for the effects on the growth of the germ tubes, and some of the hybridoma culture supernatants studied showed growth stimulatory effects.
2004 상반기 부산 지역에서 유행한 인플루엔자의 임상 역학적 분석 및 인플루엔자 진단에 있어서의 신속 항원 검사법
최소영,이나영,김성미,김길현,정진화,최임정,조경순,Choi, So Young,Lee, Na Young,Kim, Sung Mi,Kim, Gil Heun,Jung, Jin Hwa,Choi, Im Jung,Cho, Kyung Soon 대한소아감염학회 2004 Pediatric Infection and Vaccine Vol.11 No.2
목 적 : 인플루엔자는 매년 전 세계적인 유행을 일으키는 급성 호흡기 질환으로 높은 이환율과 사망률을 보이나 국내에서는 진단법에 있어 임상 진단에 의존하고 있는 실정이다. 본 저자들은 2004년 상반기 부산 지역에서의 인플루엔자의 역학적 특성과 임상 양상 및 인플루엔자의 진단에 있어서 신속 항원 검사법인 QuickVue 인플루엔자 테스트의 유용성에 대하여 연구하여 인플루엔자 감시 및 진단, 치료에 있어서 기초 자료를 제공하고자 한다. 방 법 : 2004년 1월부터 6월까지 부산 메리놀병원 외래, 입원 및 응급실 방문 환아 중 인플루엔자 바이러스 감염이 의심이 되는 환아의 발병 시기, QuickVue 인플루엔자 테스트의 결과 및 인플루엔자 바이러스 배양 결과와 인플루엔자 바이러스가 배양된 환아들의 발병 시기, 성별, 연령, 임상진단, 임상 양상, 검사 소견, 인플루엔자 예방 접종 유무, QuickVue 인플루엔자 테스트 결과 및 치료 경과에 대하여 후향적으로 조사, 분석하였다. 결 과 : 1) 연구 기간 중 621명의 인플루엔자 의심 환아 중 QuikcVue 인플루엔자 테스트 양성은 181례(29.1%), 인플루엔자 바이러스 배양 양성은 79례(12.7%)이었다. 2) QuickVue 인플루엔자 테스트 양성 181례 중 74례(40.8%)에서 인플루엔자 바이러스가 배양되었고 QuickVue 인플루엔자 테스트 음성 440례 중 5례(1.1%)에서 인플루엔자 바이러스가 배양되었다. 3) 인플루엔자 바이러스가 분리된 환아들 중 A형 인플루엔자가 65례(82.2%), B형 인플루엔자가 14례(17.7%)이었다. 4) 인플루엔자 의심 환아 621명의 발병 월별 분포는 2004년 1월 32례(5.1%), 2월 67례(10.8%), 3월 298례(47.9%), 4월 204례(32.8%), 5월 14례(2.2%), 6월 6례(0.9%)로 3, 4월까지 집중적으로 발생하였고 인플루엔자 바이러스가 분리된 79명의 발병 월별 분포는 3월 49명(62%), 4월 30명(37.9%)이었다. 5) 인플루엔자 바이러스가 분리된 79명 중 남아가 44명(55.6%), 여아가 35명(44.3%)으로 남녀 성비는 1.2 : 1로 남아가 더 많았다. 6) 인플루엔자 바이러스가 분리된 79명의 환아들의 중앙연령은 4년 6개월(11개월~16세) 이었고, A형은 4세 7개월(11개월~16세), B형은 5세 9개월(13개월~14세)로 A형이 B형보다 중앙 연령이 낮았다. 7) 인플루엔자 바이러스가 분리된 환아들의 임상진단은 기관지염이 27례(34.1%)로 가장 많았고, 폐렴 21례(25.3%), 합병증을 동반하지 않은 인플루엔자 18례(22.7%), 급성 중이염14례(17.7%), 크룹 5례(6.3%), 천식악화 3례(3.7%), 부비동염 1례(1.2%), 열성 경련 1례(1.2%)순이었으며 2가지 이상의 진단명을 가진 경우도 흔하였다. 8) 인플루엔자 바이러스가 분리된 환아들의 임상양상으로는 발열이 79명(100%)의 환자에서 나타났고 기침은 71명(89.8%)에서 나타났고 그 외 흔한 증상은 비루 71명(89.8%), 인두통 48명(60.7%), 두통 38명(48.1%), 오한 36명(45.5%), 근육통 30명(37.9%), 소화불량 28명(35.4%), 복통 19명(24.0%), 설사 16명(20.2%), 구토 5명(6.3%), 경련 2명(2.5%)순으로 나타났다. 9) 인플루엔자 바이러스가 분리된 환아들의 진찰 소견으로는 인두 발적 70명(88.6%), 편도 비대 41명(51.8%), 건성 수포음 26명(32.9%), 수포음 8명(10.1%), 고막 충혈 8명(10.1%), 결막 충혈 5명(6.3%), 천명 3명(3.7%), 협착음이 3명(3.7%)에서 동반되었다. 결 론 : 인플루엔자는 매년 겨울과 봄에 유행하는 소아 호흡기 감염의 중요한 원인으로 소아의 건강상에 많은 영향을 끼치고 있으므로 적절한 예방, 진단, 치료가 필수적이다. 인플루엔자의 진단에는 보편적으로 임상적 진단과 바이러스 배양법이 사용 Purpose : Although influenza is one of the most important cause of acute respiratory tract infections in children, virus isolation is not popular and there are only a few clinical studies on influenza and diagnostic methods. We evaluated the epidemiological and clinical features of influenza in children and rapid antigen detection test(QuickVue influenza test) on fist half of the year 2004 in Busan. Methods : From January 2004 to June 2004, throat swab and nasal secretion were obtained and cultured for the isolation of influenza virus and tested by rapid antigen detection test(QuickVue influenza test) in children with suspected influenza infections. The medical records of patients with influenza virus infection were reviewed retrospectively. Results : Influenza viruses were isolated in 79(17.2%) out of 621 patients examined. Influenza virus was isolated mainly from March to April 2004. The ratio of male and female with influenza virus infection was 1.2 : 1 with median age of 4 years 6month. The most common clinical diagnosis of influenza virus infection was bronchitis. There was no difference between influenza A and B infection in clinical diagnosis and symptoms. All patients recovered without severe complication. The sensitivity obtained for rapid antigen detection test (QuickVue influenza test) was 93.6% and the specificity was 80.2%, the positive predictive value 40.8%, the negative predictive value 98.8%. Conclusion : With rapid antigen detection test, it is possible early detection of influenza in children. reduction in use of antimicrobial agent and early use of antiviral agent.
최소영(So Young Choi),김세중(Sei Joong Kim),조영업(Young Up Cho),박재영(Jae Young Park),박정미(Jeong Mi Park),주영채(Young Chae Chu),최윤미(Yun Mee Choe),최선근(Sun Keun Choi),허윤석(Yoon Seok Heo),이건영(Keon Young Lee),안승익(Seung 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.76 No.5
Purpose: Apocrine carcinoma of the breast is rare and there is confusion about the criteria of its histopathologic diagnosis. The purpose of this study is to investigate the clinical and pathologic characteristics of the disease. Methods: 9 patients diagnosed with apocrine carcinoma or apocrine carcinoma in situ and 1,009 patients diagnosed with non-apocrine carcinoma of the breast from April 1999 to March 2008 were retrospectively analyzed. Results: The mean age of the patients with apocrine carcinoma was 52.3 year. 5 patients (55.6%) among 9 patients with apocrine carcinoma were postmenopausal. There were 2,1 and 6 patients with stage 0, Ⅰ and Ⅱ disease, respectively according the TNM stage. These demographic and clinical differences between the patients with apocrine carcinoma and non-apocrine carcinoma were not significant. Only four patients (44.4%) were preoperatively diagnosed with apocrine carcinoma or apocrine carcinoma in situ. By surgical biopsy, additional 5 patients were diagnosed as apocrine carcinoma. In the immunohistochemical study, Bcl-2 was positive in one (12.5%) of 8 patients. p53 was positive in 4 (44.4%) of 9 patients. Expressions of estrogen and progesterone receptor were positive only in two patients (22.2%) with weakly positive staining. Androgen receptor was positively expressed in all cases (100%) of apocrine carcinoma. Overexpression of c-erb-B2 was detected in four patients. Conclusion: Treatment modality and prognosis of apocrine carcinoma are similar as non-apocrine carcinoma. But its preoperative diagnosis is more difficult than that of non-apocrine carcinoma and it shows different expression of hormone receptor. Further study is needed for the development of new hormonal therapy using androgen.
Castleman병에 동반된 신장 및 위장관 유전분증 1예
최소영 ( So Young Choi ),이동영 ( Dong Young Lee ),정경환 ( Kyung Hwan Jeong ),문주영 ( Joo Young Moon ),이상호 ( Sang Ho Lee ),이태원 ( Tea Won Lee ),조경삼 ( Kyung Sam Cho ),이주희 ( Ju Hee Lee ),임천규 ( Chun Gyoo Ihm ) 대한신장학회 2010 Kidney Research and Clinical Practice Vol.29 No.2
Castleman`s disease is a rare disorder and thought to occur as a result of chronic antigenic stimulation due to an unknown infectious or inflammatory etiology. It has a heterogenous course: the symptoms persist in some cases for many years and have a progressive fatal course in others. Renal dysfunction in the form of nephrotic syndrome is quite a rare occurrence. Secondary amyloidosis due to Castleman`s disease has also been reported in a few case reports. A 46-year-old female who had asymptomatic abdominal lymphadenopathy was diagnosed with Castleman`s disease-plasma cell type in our hospital in 2006. Three years after diagnosis, she developed chronic diarrhea, weight loss, anemia and nephrotic range proteinuria. The etiology of symptom was found to be secondary amyloidosis based on renal and gastrointestinal biopsies. She was discharged with steroid therapy. Unfortunately, she had a progressive fatal course. One month after the treatment, she developed thrombocytopenia and died due to cerebral hemorrhage.
신영민(Young-Min Shin),최소영(So-Young Cho),김진욱(Jin-Wook Kim),변기정(Ki-Jung Byeon),김진수(Chin-Soo Kim) 대한구강악안면외과학회 2011 대한구강악안면외과학회지 Vol.37 No.1
Polymorphous low-grade adenocarcinomas (PLGA) are distinctive salivary gland neoplasms with a propensity to arise from the minor salivary glands. The most frequent location of PLGA is the palate, even though other locations have been described. Previously used terms for PLGA include lobular carcinoma and terminal duct carcinoma. Although the frequency of the tumor is unknown, the recognition of PLGA as an individual tumor has increased with the establishment of specific histopathological criteria characterizing the PLGA. The first choice of treatment is a wide surgical excision including the subjacent bone if necessary. The prognosis is generally good and the recurrence rate ranges from 17% and 22%. Distant metastases is unusual (9%) but occur mainly in the regional lymph nodes. This is a case report of a 67 year old female patient with PLGA who was treated with a wide excision by layers (2 stage) of the lesion including the surrounding bone. We present this case with a review of the relevant literature.
당뇨병성 만성 신장병 환자에서 신장내과 전과 시기가 예후에 미치는 영향
이동영 ( Dong Young Lee ),최소영 ( So Young Choi ),조성연 ( Sung Yeon Cho ),박지영 ( Ji Young Park ),이상호 ( Sang Ho Lee ),임천규 ( Chun Gyoo Ihm ),이태원 ( Tae Won Lee ) 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.4
Purpose: Diabetic patients with chronic kidney disease (CKD) are associated with a significantly poorer prognosis following renal replacement therapy (RRT) in comparison to those with nondiabetic CKD. To improve such prognosis, it is crucial to achieve a timely referral to nephrologists. This article evaluated the impact the timing of nephrology referral has on prognosis in patients with diabetic CKD. Methods: Retrospective study was conducted regarding 239 patients with diabetic CKD on RRT. Patients were grouped according to referral patterns with those referred more than 1 month prior to initiating dialysis designated as early referral (ER) group and those referred within 1 month as late referral (LR) group. Characteristics of patients and risk factors for 3-month and 1-year mortality were analyzed, and mortality rates of ER and LR groups were compared using Kaplan-Meier curves of 1-year mortality. Results: LR group showed a significantly higher (p=0.023) 1-year mortality rate and more frequently required urgent dialysis or angiocatheter and complicated congestive heart failure (CHF), pulmonary edema. Contrarily, ER group showed a significantly lower mortality rate (p=0.0179) based on Kaplan-Meier survival curve of 1-year mortality. According to logistic regression analysis, CVD (OR=7.695) and low total cholesterol level (OR=0.979) and CVD (OR=8.021), emergent dialysis (OR=3.734), and high HbA1C level (OR=1.528) were risk factors of significance of 3-month and 1-year mortality, respectively. Conclusion: Among diabetic patients with CKD, late-referred group was associated with a significantly higher rate of 1-year mortality. With LR as a risk factor of 1-year mortality according to univariate analysis, timing of referral is a critical prognostic factor.