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Acute Dose-Related Differential Effects of Methylphenidate on Murine Cystometric Parameters
최성호,조영삼,조성태,이택,김계환 대한배뇨장애요실금학회 2013 International Neurourology Journal Vol.17 No.4
Purpose: Methylphenidate is the most widely used central nervous system stimulant in patients with attention deficit hyperactivity disorder. However, few studies have assessed its effects on voiding. Various doses of methylphenidate were investigated for their effects on cystometric parameters in conscious mice. Methods: Ten male C57BL/6 mice, weighing between 20 and 23 g, were used in this study. To compare the acute drug responses before and after the oral medication was administered in the awake condition, we injected the solution through a catheter inserted into the stomach. Methylphenidate (1.25, 2.5, and 5 mg/kg) in an injection volume of 0.05 mL was administered. Results: Four mice that received high doses of methylphenidate (2.5 and 5 mg/kg) showed no voiding contraction, with urine leakage. Six mice that received a low dose of methylphenidate (1.25 mg/kg) showed typical micturition cycles before and after administration. The micturition pressure decreased and bladder capacity increased without an increased residual volume after administration. Conclusions: Methylphenidate has differential, dose-dependent effects on the function of the lower urinary tract, due to the dependent relationship between the brain and lower urinary tract. Especially at higher doses, this drug may interfere with normal micturition. Therefore, more detailed clinical or experimental studies are warranted in the future.
반복적인 펄스레이저 조사에 의한 알루미늄 합금의 표면상태 변화분석
최성호,김정석,장경영,신완순,Choi, Sung-Ho,Kim, Chung-Seok,Jhang, Kyung-Young,Shin, Wan-Soon 한국군사과학기술학회 2011 한국군사과학기술학회지 Vol.14 No.5
The objective of this study is to investigate the thermal behavior on material surface and the variation in the surface morphology of aluminum 6061 alloy by the Nd:YAG pulsed-laser irradiation. First, we predicted the surface temperature variation during pulsed-laser irradiation by using the two dimensional finite element analysis. When the pulsed-laser of 133 mJ energy and 5 ns pulse duration is irradiated on the surface of aluminum alloy, the material surface is thought to be melting because the surface temperature rises steadily up to about $660^{\circ}C$ exceeding the melting point. Also, the experimental results show that the solidification microstructure has been developed clearly after surface melting. Second, the diameter of melted zone was analysed by finite element analysis and measured by OM(Optical Microscopy). It increased logarithmically with increase in the number of laser irradiation. In addition, AFM(Atomic Force Microscopy) measurement showed an increase in the average surface roughness during pulsed-laser irradiation.
최성호,이병환,이철수,정의림,Choi, Sung-Ho,Lee, Byung-Hwan,Lee, Chul-Soo,Jeong, Eui-Rim 한국정보통신학회 2012 한국정보통신학회논문지 Vol.16 No.1
본 논문에서는 다중 대역 전송 시스템에서 광대역 전력 증폭기의 선형화를 위한 새로운 전치왜곡 기법을 제안한다. 특히, 한 시스템에서 동시에 다중대역/다중모드 신호를 전송함에 있어 다중대역 신호가 하나의 전력 증폭기에 의해 증폭되어 전송되는 시스템을 고려한다. 상호 대역 간 비선형 왜곡을 포함한 비선형 특성을 보상하기 위하여, 본 논문에서는 다중 전치왜곡기 블록을 갖는 새로운 전치왜곡 구조를 제안하며, 다중 전치왜곡기의 계수를 동시에 갱신하는 적응 알고리즘을 제안한다. 제안하는 다중 대역 모델을 검증하기 위하여 상용 증폭기를 사용하여 증폭기 모델을 추출하였으며, 추출된 모델을 기반으로 제안한 알고리즘을 모의실험을 통해 검증하였다. 모의실험 결과는 제안 알고리즘이 효과적으로 다중 전치왜곡기의 계수를 구할 수 있으며, 다중 대역을 효과적으로 선형화 할 수 있음을 보여준다. New digital predistortion technique is proposed for power amplifier linearization in multi-band transmission systems. We consider a system where muli-band signals are combined and amplified by a single power amplifier (PA). In this system, the PA output is distorted by the nonlinear cross-products between different band signals as well as their own nonlinear self-products. To compensate these nonlinear effects, we propose a multiple PD structure. Each PD removes the nonlinear cross-products and self-products to mitigate the spectral regrowth for the corresponding band. Since the PD parameters for different bands are linked together, it is difficult to find the PD parameters separately. Thus, we propose an iterative method for finding the PD parameters jointly. For demonstration of the proposed method, multi-band characteristics of PA are extracted from a commercial power amplifier. Computer simulation was executed based on the PA parameters. The simulation results show that the proposed method can effectively linearize the PA and remove spectral regrowth at each signal band.