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최기욱,김흥곤,문형배 圓光大學校 醫科學硏究所 1994 圓光醫科學 Vol.10 No.1-2
The immature teratoma is the third most commin germ cell tumor of the ovary. It contains a variable amount of immature tissue derived from the three germ cell layers-ectoderm, mesoderm and endoderm. Most commonly the immature elements are neural origin. With the usage of chemotherapy following appropriate surgery, prognosis for patient with malignant germ cell tumor was improved considerably. We had experienced a case of immature teratoma of ovary. We report the case with review of the concerned literatures.
면역조직화학법에 의한 자궁경부암 및 자궁경부 상피내종양의 p53 단백검출
문형배,김기석,김흥곤,이희섭,홍기연,민부기,최기욱 대한부인종양 콜포스코피학회 1995 Journal of Gynecologic Oncology Vol.6 No.1
The cell cycle is composed of a series of steps which can be negatively or positively regulated by various factors. p53 gene aberrations are common in human malignancies, and recent studies suggest that in cervical carcinoma p53 function is inactivated either by complex formation with human papilloma virus (HPV) E6 product or by gene mutation. To study the expression of p53 gene in the cervical cancer and cervical intraepithebal neoplasia, immunohistochemistry for the p53 protein was done in the 47 cases of squamous cell carcinoma, 6 cases of adenocarcinoma and 32 cases of cervical intraepithelial neoplasia. 1. The p53 protein was detected in the 31% of cervical intraepithelial neoplasia (10/32 cases). 2. The p53 protein was detected in the 55% of invasive cervical cancer (29/53 cases). 3. By the histologic type of cervical cancer, the p53 protein was detected in the 57% of squamous cell carcinoma (27/47 cases) and 33% of(2/6 cases) adenocarcinoma. The p53 protein wes more frequently detected in the squamous cell carcinoma than in the adenocarcinoma. 4. By the staging in cervical cancer, the p53 protein was detected in the 31% of stage 0, 50% of Stage Ia, 50% of stage I b, 75% of IIa and 50% of stage IIb.