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      • 급성 뇌경색 환자에서 혈중 Human Heat Shock 단백질 농도 및 항체수준의 상관관계

        채승희 대한뇌졸중학회 2005 Journal of stroke Vol.7 No.2

        Background: Infection, inflammation and autoimmunity have been associated with pathogenesis of atherosclerosis.Nucleated cells express Heat Shock Protein (HSP), evolutionary highly conserved molecules, in response toenvironmental stress with inflammation. For carotid atherosclerosis and myocardial infarction, an association withan increase in anti-HSP 65 antibodies has been demonstrated. But data regarding HSP in ischemic stroke are yetsparse. The aim of our study was to investigate whether ischemic stroke is associated with a humoral immuneresponse to HSP. Methods: This case-control study includes a complete profile of anti-HSP 60/70 antibody andHSP 60/70 proteins in acute ischemic stroke patients. Eighty-eight patients with acute ischemic stroke and 90 controlswere evaluated for conventional risk factor, and levels of HSP protein and antibodies. The levels of IgG antibodyto HSP 60/70 and circulating HSP 60/ 70 proteins were measured by emzyme-linked immunosorbent assay.Results: Ischemic stroke was connected with a significant elevation of anti-HSP60 and 70 antibodies levels andHSP 70 protein compared with controls (p〈0.001). The multifactorial logistic regression analysis showed thatincreased levels of anti-HSP 60 and 70 IgG antibodies were independent markers for stroke. Conclusions: Ourstudy suggest that expression of HSP may be a marker in the development of atherosclerosis, if atherosclerosis isconsidered as an immune disease.(Korean Journal of Stroke 2005;7(2): 151~158)

      • KCI등재

        「한국교회사학회지」에 나타난 고대교회역사 연구 동향과 전망

        채승희 한국교회사학회 2020 韓國敎會史學會誌 Vol.55 No.-

        한국교회사학회 50주년을 기념하기 위한 「한국교회사학회지」 특집호(55집)에 고대교회사 연구동향 분석과 미래전망에 대해 나눌 수 있는 기회가 주어짐에 대해, 깊은 감사를 표한다. 본고는 전체 420여 편의 전체 논문 중 77편의 고대교회사 논문을 다루었다. 포스트모던적 사조와 신학적 배경으로 크게 4개의 범주(역사관, 주제, 방법론, 저자)로 나누어 논문들의 성향과 내용을 분석하였다. 포스트모더니즘 시대는 근대적 사고에서 탈피하고 지배담론이나 거대 담론의 해체를 주장하면서 소위 “아래로부터”의 신학을 추구한다고 하겠다. 이에 따라 지금까지 역사적으로 소외되고 주목 받지 못했던 약자들에게 초점을 맞추고, 그들이 역사 연구의 중심주제로 떠오르고 있다. 탈가부장적, 탈유럽적, 탈교리적, 탈교파적, 탈제도적 사고가 주가 된다고 하겠다. 이러한 사고로 역사 연구에 다양한 방법론이 시도되고 다양한 접근이 이루고 지고 있다. 물론 전통적인 주제들을 다루는 연구도 활발하게 역사 연구에 기여하고 있다. 마지막으로 필자는 본 학회의 발전과 학문적 공헌을 위해 학제간 학회나 연구 등 프로그램을 발전시켜 나갈 필요가 있다고 제안하였다. 역사가 신학, 영성, 상담, 윤리, 예배 등과 어우러 질 때 교회 현장은 물론 우리가 더불어 살아가는 사회와 함께 소통하고 하나님 나라를 확장할 수 있기 위해 노력해야하기 때문이다. On the occasion of the 50th anniversary of the Church History Society of Korea, it is a great honor for me to analyze and evaluate the articles on Early Christianity in our JCHSK since 1979. I examine those 77 articles on the early church through four categories, historical viewpoints, themes, methodologies, and authors. Finally, I suggest a plan for improving future academic and pastoral contributions, both to the church and to society. The new trends of research in church history are “from below.” The perspectives of the alienated or marginalized classes, genders and races has been promoted as the central theme of historical study. Provocative achievements have, of course, also resulted from research done in traditional methods and themes. Along with the postmodernist thoughts, more practical issues for the church such as spirituality, Christian education, worship and liturgy are also linked with historical theories. To promote the advancement of academic research in the Church History Society of Korea, I believe it is important that we develop interdisciplinary programs. Incorporating modern perspectives on theology and history into educational materials as well as products for the daily practices of the church will enable all Christians to be more effective communicators of the Gospel for all those we serve.

      • KCI등재

        대구지역 의료선교의 아버지: A. G. Fletcher에 대한 소고

        채승희 장로회신학대학교 세계선교연구원 2022 선교와 신학 Vol.56 No.-

        본고는 의료선교사 Archibald G. Fletcher의 삶과 사역을 소개한다. 그는 1911년부터 1942년까지 30년을 대구지역 의료 사역에 헌신했다. 대구·경북지역 초기 선교 역사가 주로 목회자 중심으로 연구가 이루어지다보니 평신도 의료선교사였던 플레처의 생애와 사역에 대한 연구가 상대적으로 크게 주목받지 못했다. 그가 초기 대구지역 선교 역사에 미친 영향이지대하므로 그의 삶과 사역은 충분히 연구의 가치가 있다. 그는 한국과 한국인을 위한 선교사였으며 복음의 열정이 남달라 복음 전도자로 수많은 영혼을 그리스도께 인도했다. 그리고 박애적 인도주주의 정신으로 환자들을대했으며 특별히 한센인들의 삶과 환경을 인도적 차원에서 개선했다. 미감아와 당시 영양상태가 좋지 못한 한국의 아이들의 건강과 교육을 위해서기여한바 크다. 30년 동안 그의 헌신적 사랑과 노력으로 대구 선교기지는서양 선교사가 세운 가장 큰 병원들 중 하나인 동산병원과 한센인 병원을세우고 운영할 수 있었다. 이는 대구지역 복음 전파와 교회 성장에도 크게기여했다. 이제 우리는 초기 대구지역 선교 역사에서 그가 일구어낸 업적들과 그가 물려준 고귀한 신앙의 유산들을 기리며, 의료선교사 Archibald G. Fletcher 이름을 길이 기억해야 할 것이다.

      • KCI등재

        마르켈라(325∼410)와 아벤티누스 회(會)

        채승희 한국교회사학회 2011 韓國敎會史學會誌 Vol.29 No.-

        In this article, I will press for some changes in the way we think about the role of women in early Christianity. Marcella(325∼410) played a much more creative role than often thought in shaping spirituality in the Roman setting during the mid-fourth century, the period of barbarian invasions. Marcella was a highborn lady from a line of consuls and prefects. She, as an aristocratic woman, was the first in Rome to accept the monastic vocation. Marcella created the Aventine Circle which provided the original impetus for the flowering of Roman female monasticism. She was an important teacher in the early church who was highly esteemed by Jerome. She was in the front lines in interacting with heretics and bringing them to a better understanding of Christian truth. At one point, when a dispute arose in Rome concerning the meaning of the Scriptures, Jerome asked Marcella to settle it. It is wrong to give Jerome the credit for inspiring or shaping Marcella’s spirituality and her Aventine Circle. It is also a mistaken notion that Marcella was at best a satellite or disciple of Jerome. By the time Jerome appeared in Rome in 382, the Aventine Circle had already assumed its basic pattern of monastic life, centering around intensive study of scripture, prayer, fasting, almsgiving and so on. Although he taught scriptures and encouraged their asceticism, he could not have shaped the Aventine Circle, which by this time had already been in existence thirty years or more. Moreover, Jerome commented that their scholarship on biblical study was far beyond normal. Jerome leaves ample evidence that he considered Marcella a biblical scholar. She was fluent in Greek as well as Latin and had an intense desire to master Hebrew. Jerome saw Marcella his equal as an interpreter of the Scripture. Looking in a new way at the evidence, I believe there are ample reasons for retelling the story of early Christianity in the West. As a founder of the Aventine Circle, as a role model of a monastic lifestyle for devout women of Roman aristocracy, and because of her highly intelligent scholarship on the Bible, Marcella was a major player in the development of Christian spirituality.

      • KCI등재

        단기간 비사용 근위축 후 운동에 따른 caspase-3 m-RNA 변화

        채승희 한국웰니스학회 2008 한국웰니스학회지 Vol.3 No.2

        This study examined the effect of exercise after induction of muscle disuse atrophy on apoptosis related gene, Caspase-3 m-RNA. We divided the mice (ICR) after induction of muscle disuse atrophy into 2 groups: exercise (20 mice) and non-exercise (20 mice). Analyses were made comparing among time periods of stable base, one day, three day, five day, and seven day after treatment. In each group, three mice were decapitated cervically during which apoptosis related gene, Caspase-3 m-RNA were compared. The Caspase-3 m-RNA expression showed a significant statistical difference in non-exercise group's 3rd, 5th, and 7th days (p<.001). When stabilized, there was little significant difference in non-exercise group's 1st day. Based on the results, it could be interpreted as that a steady increase load training method can be more effective than continued stability in patients who have the muscle atrophy due to an accident or a bed safety muscular power exercise insufficiency treatment. Caspase-3 m-RNA that promotescell death showed a significant statistical increase.

      • KCI등재

        공황장애 환자에서의 작업기억 장애

        채승희,신영철,신동원,오강섭,전상원,조성준 대한불안의학회 2021 대한불안의학회지 Vol.17 No.1

        Objective : The purpose of this study was to investigate the impairment of working memory in patients with panic disorder through neuropsychological examination. Methods : A total of 38 patients who met the DSM-5 criteria for panic disorder and 40 healthy controls were recruited in this study. Controls and patients were matched for age, sex, and education. The Hamilton Anxiety Rating Scale (HAMA), the Hamilton Depression Rating Scale (HAMD), and the Panic Disorder Severity Scale (PDSS) were used to evaluate the severities of anxiety, depression, and panic disorder. Further, the digit span task was performed to assess working memory. In addition, a sub-analysis was performed after excluding participants with clinical depressive symptoms. Finally, a sub-analysis by the education level was performed. Results : The HAMA, HAMD, and PDSS scores were significantly higher for patients with panic disorder compared to controls. The scores of digit span forward, digit span backward, digit span sequencing, and total digit span were significantly lower for patients with panic disorder compared to controls. In the sub-analyses excluding patients with depression and by education level, the score of total digit span was significantly lower for patients with panic disorder compared to controls. Conclusion : In this study, patients with panic disorder had deficits in working memory compared to healthy controls. (Anxiety and Mood 2021;17(1):41-47)

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