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손민정,진창배,이용섭,이재열,김형자 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.2
In the search for xanthine oxidase (XOD) inhibitors as anti-gout agents from natural products, various chromatographic separations of the ethyl acetate-soluble fraction of Aster glehni (AGEF) led to the isolation of five new caffeoylglucoside derivatives, namely 6′-O-caffeoyl-(6S,9R)-roseoside (1), 6′-O-caffeoylampelopsisionoside (2), 6′-O-caffeoylsonchuinoside C (3), 6′-O-caffeoyldihydrosyringin (4), and (2E)-2-methyl-but-2-ene-1,4-diol-6′-O-caffeoyl-1-O-β-glucopyranoside (glehnoside, 5), together with 13 known compounds. The absolute stereochemistry of the 6′-O-caffeoylsonchuinoside C (3) was established with the help of spectroscopic analyses, enzymatic hydrolysis, and Mosher's method, as well as in comparison with literature data. All isolated substances were determined for their inhibitory activities on uric acid production by the xanthine/XOD system. Among them, 4,5-O-dicaffeoylquinic acid methyl ester (12) showed the most potent inhibitory activity with an IC50 value of 2.6 ± 0.1 μM, which was comparable to that of allopurinol used as a positive control. Furthermore, hypouricemic effects of AGEF were assessed by measuring serum uric acid levels 3 h after potassium oxonate treatment (250 mg/kg, i.p.) to induce hyperuricemia in rats. When preadministered orally once a day at doses of 50, 100, and 300 mg/kg for 7 days, AGEF reduced the potassium oxonate-induced elevated serum uric acid level by 15.4, 39.8, and 32.3%, respectively. The results suggest that AGEF has the potential to be a new source of agents for the prevention and/or treatment of hyperuricemia and gout.
이종임,진창배,류재하,조정숙,Lee, Jong-Im,Jin, Chang-Bae,Ryu, Jae-Ha,Cho, Jung-Sook 대한약학회 2008 약학회지 Vol.52 No.2
The leaves of Perilla frutescens Britt. var. japonica Hara (Labiatae) are often used in gourmet food in several Asian countries. Two kinds of perilla cultivars, Namcheon (NC) and Bora (BR), have been respectively developed in Korea by the pure line of 'deulkkae' from the local variety and by the cross of 'deulkkae' and 'chajogi'. The present study evaluated and compared antioxidant and neuroprotective effects of the fractions prepared from the leaves of the two cultivars using cell-free bioassay systems and primary cultured rat cortical cells. We found that the spirit, chloroform, hexane and butanol fractions from NC and BR leaves inhibited lipid peroxidation initiated in rat brain homogenates by $Fe^{2+}$ and L-ascorbic acid. In contrast, only the spirit and butanol fractions from both cultivars exhibited 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity. Among the fractions tested, the butanol fractions from NC and BR leaves exhibited the most potent antioxidant properties, and the butanol fraction from BR was more potent than the NC fraction. In consistence with these findings, the butanol fractions from both cultivars protected primary cultured cortical cells from the oxidative damage induced by $H_2O_2$ or xanthine and xanthine oxidase, with the BR butanol fraction being more active. The butanol fractions from NC and BR did not produce cytotoxicity in our cultures treated for 24 h at the concentrations of up to $100\;{\mu}g/ml$. Taken together, these results indicate that the leaves of the two cultivars of Perilla frutescens exert antioxidant and neuroprotective effects, and that the butanol fraction from BR leaves exhibits the most potent antioxidative neuroprotection among the fractions tested in this study.
김진안,조효제,진창배 부산대학교 1994 生産技術硏究所論文集 Vol.47 No.
It is an important problem to consider the mechanism of capsizing of a ship in waves in the design of ship. Especially, the inclined vessels which were caused by the cargo shift or inclining initially by the wind force etc, are easy to be capsized in comparison with the upright vessel. In this paper, we investigate the characteristics of roll motion of the inclined vessel in following seas by meas of the analysis of parametric oscillation. We derived the nonlinear equation of motion to express the roll motion of the inclined vessel and compared with behaviour of the upright vessel. It is known that capsizing phenomena of the inclined vessel which occur instantaneously in the following seas, can be explained well by the solution of the nonlinear equation. 파랑중 선박의 전복 메카니즘을 규명하는 것은 선박의 안전한 설계를 위하여 다루어져야 할 또하나의 중요한 문제이다. 특히 적하물의 이동이나 바람에 의한 경사모멘트 등에 의하여 경사된 선박의 경우에는 직립선에 비하여 전복될 위험이 많은 것으로 알려져 있다. 따라서, 본 논문에서는 파라메트릭 진동의 관점에서 추파중을 항해하는 초기 경사선의 횡요운동 특성을 조사하여, 선체의 전복 현상을 고찰한다. 위를 위하여 우선 초기 경사선에 대한 비선형 운동방정식을 유도하여 그 운동방정식의 해를 직립선에 대한 것과 서로 비교 검토하였다. 그 결과 추파중을 항해하는 초기경사선이 아주 짧은 시간에 전복하는 현상은 본 논문에서 설정한 비선형 운동방정식으로서 충분히 설명할 수 있음을 보였다.