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Recent Trends for the Management of Crohn’s Disease
최은영,진지용,조광근,최인순 대한암예방학회 2012 Journal of cancer prevention Vol.17 No.3
Crohn’s disease is characterized with chronic inflammatory bowel disease, which shows the occurrence of nonspecific granuloma necrosis in the whole alimentary canal, from the oral cavity to the anus. It causes the formation of ulcers, cracks, and fissures by irritating mucosal membrane. The possible outcomes are abscess, intestinal obstruction, bowel perforation, and enterocutaneous fistula if the condition worsens. In general, it includes the symptoms of abdominal pain, diarrhea, appetite loss, slight fever, and enterohemorrhage. So far, the causes of Crohn’s disease have not been identified, but are considered to be attributable to mixtures of environmental and genetic factors. Crohn’s disease continues to cause inflammation of the gastrointestinal tract to the point where, even the immune response factor of a viral or bacterial infection disappears due to the activation of the immune system, which consequently will cause the loss of immune system. Crohn’s disease is related to intestinal microbiome. Patients have less ‘Faecalibacterium prausnitzii’ bacteria, whereas the adherent invasive Escherichia coli count tends to be increased. Soluble dietary fiber suppresses the adhesion and invasion of Crohn’s disease-related harmful bacteria to the intestinal wall. Butyrate, derived from soluble dietary fiber, provides the fundamental ingredient for treating Crohn’s disease due to its anti-inflammatory efficacy. Therefore, we suggest butyrate as the substance for more effective and safe treatment of the disease to increase immune function without the presence of side effects.
실내용 위치센서의 특성과 이동로봇의 주행제어에 관한 실험적 연구
안재완,진지용,정우진 한국로봇학회 2010 로봇학회 논문지 Vol.5 No.3
For indoor mobile robots, the performance of autonomous navigation is affected by a variety of factors. In this paper, we focus on the characteristics of indoor absolute positioning systems. Two commercially available sensor systems are experimentally tested under various conditions. Mobile robot navigation experiments were carried out, and the results show that resultant performance of navigation is highly dependent upon the characteristics of positioning systems. The limitations and characteristics of positioning systems are analyzed from both quantitative and qualitative point of view. On the basis of the analysis, the relationship between the positioning system characteristics and the controller design are presented.