Inhibitory Effect of Agaricus Mixed Prescription on Metastasis and tumor Formation

주지희,임낙철,김성훈,류기원 한의병리학회 2003 동의생리병리학회지 Vol.17 No.2

Ruxolitinib for Treating Steroid-Refractory Acute Graft-Versus-Host Disease in an Infant with Malignant Osteopetrosis Who Received Double-Unit Umbilical Cord Blood Transplantation

주지희,심예지,김성애,정혜라 계명대학교 의과대학 2021 계명의대학술지 Vol.40 No.2

A 3-month-old male infant was transferred to our hospital due to bicytopenia. His bone marrow biopsy showed irregular bony trabeculae with cartilaginous core, which was consistent with osteopetrosis. In the genetic test, c.242del (p.Pro81Argfs*85) in TCIRG1 was found to be homozygotic, thus he was diagnosed with malignant infantile osteopetrosis. At 6 months of age, he received double-unit umbilical cord blood transplantation (UCBT) with the conditioning regimen including busulfan, cyclophosphamide, and rabbit anti-thymocyte globulin. Initially, single UCB was infused to the patient, but the post infusion viability of the UCB was unexpectedly low. Thus, another UCB was additionally infused. Cyclosporine and mycophenolate mofetil were used for graft-versus-host disease (GVHD) prophylaxis. Neutrophils and platelets were engrafted on day +13 and +33, respectively. With engraftment, he showed overall grade 4 acute GVHD involving the skin and gut, which was refractory to corticosteroids. Despite treating with low-dose weekly methotrexate (10 mg/m2) and oral beclomethasone, his symptoms persisted. After treating with ruxolitinib 2.5 mg/day for 2 weeks, and 5 mg/day thereafter, his diarrhea stopped in 2 weeks and his skin symptoms gradually improved over 3 months. The short tandem repeats showed 100% donor chimerism at 1 and 3 months after UCBT. Currently, 4 months after UCBT, he is 10 months old. The oral prednisolone has been tapered to 0.6 mg/kg/day, and the dose of ruxolitinib was decreased to 2.5 mg/day without recurrence of GVHD. We plan to taper off the immunosuppressive agents if his GVHD symptoms do not recur.

《요나답》의 ‘요나답’ 캐릭터에 나타난 실존의 문제 - 사르트르의 주체성에 관한 실존 개념을 기반으로

주지희 ( Ju Ji-hyi ) 한국연극교육학회 2018 연극교육연구 Vol.32 No.-

The purpose of this study is to explore the importance of humans' subjective way of thinking by analyzing the problems of existence that appeared in the character “Yonadab” in Yonadab (1985) written by Peter Sheffer (1926-2016). At the beginning of the twentieth century, existentialist philosophy that was born placing emphasis on humans' subjectivity had multilateral effects on many art worlds, and the British playwright Peter Sheffer successively published diverse works dealing with the problems of existence. Yonadab belongs to the latest of Sheffer’s works as such and has the characteristic of referring to the problems of existence more directly compared to other works. With this purpose, the present study was conducted as follows. First, in the first chapter, the “imperfection” of the character 'Yonadab' set by the author was analyzed to examine the fact that in the case of Yonadab, who wanted a better world, his personality traits, such as “a lack of self-esteem,” the resultant “sense of isolation” and “unceasing disjunctions between thoughts and actions,” eventually become the triggers of failure. In the second chapter of the present study, the process by which Yonadab, who was viewing the existence of an absolute being represented by “God,” ultimately fails to acquire subjectivity by failing to escape the influence of the being, was examined. In the third chapter of this study, the attitudes taken by Yonadab, who is an individual being, toward others and the world were analyzed. Every aspect of the anger and conflicts felt by Yonadab toward other characters in the play was examined, and the problems ultimately brought about by his passive attitude toward others and the world were considered. In the last chapter of the present study, “the value of new choices” given to modern people was analyzed through questions regarding the attitudes of lives directly thrown out by Yonadab to the audience. Consequently, in connection with the thematic consciousness of Yonadab about the problems of existence, the importance of life with subjective thoughts in the hopeless world was considered. The problems of existence that appeared in the character Yonadab of Peter Sheffer’s play appear with further expansion in modern society, which has become much more complicated and diverse. Therefore, agonizing over the problems of existence with subjectivity is considered to be a quite meaningful act for numerous individuals in the world of today.

공연예술 제작환경의 뉴 패러다임 연구: 서경공연예술센터 SKON1관 디지털 트윈 제작사례를 중심으로

손민지,김두범,주지희 한국예술교육학회 2022 예술교육연구 Vol.20 No.4

본 연구는 팬데믹 이후 공연예술계의 변화 움직임을 살펴보고, 디지털 트윈 기술 기반 가상 공연장 및 가상 공연 콘텐츠 제작 사례를 고찰함으로써 향후 공연예술 제작 환경이 변화해 나가야 할 길을 타진하는 것에 최 종 목적을 둔다. 이와 같은 목적의 달성을 위해 본 연구는 다음과 같이 진행되었다. 우선 첫 번째 장에서는 공연 실황 영상 및 실시간 스트리밍 공연 등 온라인 플랫폼으로 진출한 공연예술계 현황을 살펴보았다. 이후 이른바 메타버스 로 총칭되는 가상공간 영역으로 진출한 공연 사례를 살펴보며 그 한계점을 짚어보았다. 또한 시뮬레이션 등의 기능으로 타 산업에서 중용되는 디지털 트윈 기술의 개념과 공연예술 접목에 있어서의 가능성을 언급하였다. 본 연구의 두 번째 장에서는 디지털 트윈 개념을 적용하여 구축한 가상 공연장의 실제 사례를 제시하고 그 활용성에 관해 논하였다. 다음으로는 해당 공연장에서의 시연을 전제로 제작된 가상 공연 콘텐츠 제작 사례를 살펴보고 해당 콘텐츠가 작금의 공연예술계에 전하는 의의를 제시하였다. 미처 준비되지 않은 변화의 시기, 공연예술은 유례없는 위기를 맞았지만 다른 관점에서 보면 산업의 확산을 꿈 꿀 수 있는 기회이기도 하다. 이와 같은 상황에서 디지털 트윈 기술을 공연예술에 접목하여 제작된 사례를 통해 포착된 공연 제작 환경의 뉴 패러다임은 반드시 받아들여야 할 시대적

라바노테이션 활용 창작 기보법 연구 -뮤지컬 <몽유도원도> 제작사례를 중심으로

신지훈,김소영,이승복,주지희 한국엔터테인먼트산업학회 2022 한국엔터테인먼트산업학회논문지 Vol.16 No.8

This study focuses on the development of new creative musical notation and the use of lavannotation, which is an essential element in the digital performance production process in the era of the 4th industrial revolution. Ravanotation is a musical notation that provides information optimized for the movement components of dancers. However, it is also true that the components of the existing Ravanotation have limitations in expressing various movements such as the location of the actor, movement, composition of the movement, and accessibility. Therefore, it is necessary to modify and supplement in a direction that is easy for actors to approach to create new symbols. Therefore, this study aims to develop a new creative notation based on lavannotation for smooth sharing and collaboration with actors and technical parts in the digital performance production process. Recording the movements and movements of actors in a digital performance is indispensable for collaboration with the staff. To this end, the research team divides the development process by applying creative notation in order to help improve the effective understanding of motion and cognitive process, and examines it in detail as follows. First, we will review the theoretical considerations of Ravanotation, the current status of its use, and its limitations. Second, based on this, new creative notation will be produced through stages such as planning, preparation, development, application, and execution. Third, an example of motion capture by applying this to an actual performance will be presented. Finally, the limitations and suggestions regarding the process of this study will be mentioned and concluded. This goes beyond the significance of developing musical notation that can be used in practice, and suggests a change necessary for the rapidly changing performance production process by combining with advanced technology. Therefore, it is hoped that active research will be conducted to respond to the future in various performing arts fields through this study.

A case of methamphetamine intoxication in an adolescent

김진희,정재윤,박중완,이의준,이하니,주지희 대한소아응급의학회 2023 대한소아응급의학회지 Vol.10 No.1

With the age of exposure to illegal substances decreasing and abuse of drugs such as methamphetamine increasing, substance abuse is no longer limited to adults. We report a Korean case of a 17-year-old girl with acute methamphetamine poisoning. The girl visited the emergency department for vomiting and loss of consciousness, with needle marks found on both arms. QT prolongation was confirmed on the initial electrocardiogram, so that we suspected drug addiction and proceeded with toxicologic tests. A lethal dose of methamphetamine was confirmed. We discontinued QT prolonging drugs, and closely monitored the girl in the pediatric emergency intensive care unit until the QT prolongation was resolved. This case highlights the recognition of pediatric methamphetamine poisoning in emergency departments.