비대칭 Terphenyl 유도체 합성

조철희,박광용 중앙대학교 미래신기술연구소 2003 미래신기술연구소 논문집 Vol.12 No.2

Terphenyl 유도체들은 다양한 생물학적·광학적 활성을 갖고 있으며, 천연물 및 의약품에서 광범위하게 발견되는 화합물이다. Neopentyl bromobenzenesulfonates 와 arylboronic acids를 palladium 촉매를 사용하여 반응하여 형성된 biphenylsulfonates를 arylmagnesium bromides 와 nickel 촉매 하에서 반응시킴으로써, 다양한 비대칭 terphenyl 유도체들을 우수한 수율로 합성하였다. Terphenyl derivatives possess various biological and optical activities. They have been extensively found in natural products and pharmaceuticals. A variety of asymmetric terphenyls were synthesized in high yields via the coupling reactions of biphenylsulfonates, which were prepared by the palladium-catalyzed reactions of neopentyl brombenzenesulfonates with arylboronic acids, with arylmagnesium bromides in the presence of a nickel catalyst.

집합주거단지에서 건강환경 조성을 위한 주거동의 배치유형이 통풍계획에 미치는 영향 분석

조철희,이특구 한국의료복지시설학회 2004 의료·복지 건축 Vol.10 No.2

The purpose of this study is to analyze the wind velocity ratio in respect of layout types of housing in multi-family housing. The wind velocity ratio is a difference of wind velocity between on the leeward and on the windward side of multi-family housing. The layout types of housing are grid layout pattern of linear type, mixture pattern of Linear type + tower type and layout pattern of tower type. The planning of wind flow is an induced technique to increase in wind velocity in the city and multi-family housing. This study investigates wind velocity ratio into layout types of housing. consequently, analysis were basic design data for the planning techique of wind flow suggested.

제 9 회 세계 해양공학회

조철희 한국전산구조공학회 1999 전산구조공학 Vol.12 No.2

Effect of Al2O3, MgO and SiO2 on Sintering and Hydration Behaviors of CaO Ceramics

조철희,구봉진,KeeSungLee,김도경 한국세라믹학회 2002 한국세라믹학회지 Vol.39 No.6

複合非破壞試驗法을 利用한 現場콘크리트 强度推定에 關한 硏究

조철희,김하진,이승엽,김정섭 朝鮮大學校 建設技術硏究所 1999 建設技術硏究 Vol.19 No.1

This study is to improve the reliability of compressive strength estimation using combined non-destructive testing method in estimating the compressive strength of in-situ concrete after 730 days of age, measures the values of compressive strength and non-destructive test of in-situ concrete with the combined strength of 240kg/㎠, conducts the experiment for estimating the compressive strength, makes the estimation expression of the results through simple and duplicate regressive analysis and then the results of comparing and analyzing to existing expressions to secure the range of application of estimation expression and its reliability are as follows. It is found that the positive curing is very important in the early curing of the strength revelation in long-term age and especially in hydrate and it is considered that the formation and application of estimation expression of comprressive strength according to placement and curing method are needed to enhance the degree of strength estimation of in-situ concrete. After 365 days of age, the compressive strength of concrete tends to be decreased. While the single method has not a great change of non-destructive test value according to the change of concrete strength, the combined method shows a high reliability and then it is appropriate to use it for the exact strength estimation. Existing estimation expression used for estimating the compressive strength indicates a high estimation error in comparison with the expression suggested by this research in the difference of materials used, combined strength of concrete and the difference of placement and curing methods. Accordingly, it will be desirable to use an estimation expression suitable to the in-situ conditions for the exact strength estimation. The estimation expression of compressive strength using combined non-destructive test method of in-situ concrete on 730 days of age (2 years) suggested by this research is as follows. Air Curing fc' = 7.33R+219Vp-846 [R-sq(adj) = 0.839, N=81] Water Curing fc' = 12.6R+176Vp-805 [R-sq(adj) = 0.839, N=81]

공동주택에 건강개념인 통기시스템에 관한 연구 : 공기순환과 필로티를 중심으로 focused on the air ventilation and pilotis

조철희,이특구 한국의료복지시설학회 2004 의료·복지 건축 Vol.10 No.1

The purpose of this study is to analyze the air ventilation system in apartment houses on the air circulation and pilotis. The air ventilation system is used with the data which were obtained by the environmental health, urban climate, air pollution, ventilation path. The architectural element was pilotis concept connected with piloti ratio, position and piloti type. The summaries of this study were as follows; 1) the well-being apartment concept, 2) the heat island phenomenon, 3) the oxygen density of air, 4) the definition of ventilation path, 5) the pilotis connected with residential environment improvement. In addition, the detailed case study to the air ventilation system in apartment houses be needed.

포도 송이가지를 이용한 레스베라트롤의 추출 및 항산화 활성

조철희,김소영,유귀재,손민희,박근형,임병락,김동청,채희정 한국응용생명화학회 2008 Journal of Applied Biological Chemistry (J. Appl. Vol.51 No.1

The extraction conditions for resveratrol production from grape fruit stem, which is a by-product of grape processing, were optimized to develop high-functional grape-based products. Additionally, the bioefficacy of grape fruit stem extract (GFSE) as an antioxidant agent was evaluated. Resveratrol was extracted using various experimental conditions such as extractant type, extractant concentration, raw material-extractant ratio, extraction time and temperature, and the results were analyzed using a statistical program (SPSS). The resveratrol yield was the highest when 80% ethanol with a raw-material-extractant ratio of 1 : 10 (w/v) was used. In addition, the optimal temperature and time were selected as 60oC and 90 min, respectively. When the antioxidant activity was analyzed and expressed as DPPH radical scavenging activity and SOD-like activity, the antioxidant activity of GFSE was higher than that of BHT, BHA and L-ascorbic acid. Finally, it was found that GFSE could be used as a raw material for the production of high antioxidant agents. The extraction conditions for resveratrol production from grape fruit stem, which is a by-product of grape processing, were optimized to develop high-functional grape-based products. Additionally, the bioefficacy of grape fruit stem extract (GFSE) as an antioxidant agent was evaluated. Resveratrol was extracted using various experimental conditions such as extractant type, extractant concentration, raw material-extractant ratio, extraction time and temperature, and the results were analyzed using a statistical program (SPSS). The resveratrol yield was the highest when 80% ethanol with a raw-material-extractant ratio of 1 : 10 (w/v) was used. In addition, the optimal temperature and time were selected as 60oC and 90 min, respectively. When the antioxidant activity was analyzed and expressed as DPPH radical scavenging activity and SOD-like activity, the antioxidant activity of GFSE was higher than that of BHT, BHA and L-ascorbic acid. Finally, it was found that GFSE could be used as a raw material for the production of high antioxidant agents.

생화학/분자생물학 : 개비자나무(Cephalotaxus koreana) 추출물의 항균활성 및 세포독성

조철희,유귀재,김소영,이건순,김진현,현정오,채희정 한국응용생명화학회 2009 Journal of Applied Biological Chemistry (J. Appl. Vol.52 No.2

Neopentyl Biphenylsulfonates와 Aryl Grignard Reagents의 Cross-Coupling 반응에 의한 비대칭 Terphenyls 합성

조철희,김인숙,박광응 한국공업화학회 2002 응용화학 Vol.6 No.2

Terphenyls and biphenyls, which are frequently found in natural products and pharmaceuticals, are famous for their biological and optical activities. We synthesized various asymmetric terphenyl derivatives in high yields by the palladium-catalyzed reaction of neopentyl 4-bromobenzenesulfonate with arylboronic acids followed by the nickel-catalyzed coupling with arylmagnesium bromides. Arenesulfonates proceeded the reaction in the presence of a nickel(0) catalyst via an overall nucleophilic aromatic substitution of the alkyloxysulfonyl group in reactions with Grignard reagents, while they did not react with a palladium catalyst at all. This reaction demonstrates that bromoarenesulfonates are plausible precursors for the preparation of asymmetric oligophenyls and other conjugated compounds.

소방대원 『화학사고 현장대응 가이드북』 개발 및 적용

조철희 한국위험물학회 2022 한국위험물학회지 Vol.10 No.2

In this paper, we would like to introduce the National Fire Agency(NFA) 『Chemical Incident Response Guide(CIRG-FF)』, a guidebook for responding to special chemical disasters in Korea. In the case of chemical disaster-related guidelines provided by other organizations, information is provided to workers and the public as well as responders to disasters. For this reason, it is somewhat difficult for firefighters to use them. CIRG-FF is composed of response information on historical substances(138 types) of large and small scale chemical accidents that have occurred in Korea over the past 7 years(2014-2020). And, it is composed and produced with a focus on firefighters so that rapid and efficient chemical disaster response can be safely performed, and information such as safety technology for field activities is included. Furthermore, in order to increase the utilization of CIRG-FF, the "119 e-book" was distributed to all firefighters so that chemical material information could be immediately searched and understood by using the smartphone application(App) at the disasters.