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인체 면역결핍 바이러스 감염 환자에서 발생한 재발성 안면신경 마비 1예
조창건 동국대학교 의학연구소 2008 東國醫學 Vol.15 No.1
HIV 감염에 의해 발생한 안면신경 마비는 드물게 보고되는 신경학적 합병증의 하나이다. 안면신경 마비는 HIV 감염의 어느 단계에나 나타날 수 있으나 특히 감염의 초기에 잘 나타나며, HIV에 의한 일차적인 손상이나 대상포진 바이러스 등에 의한 이차적 감염의 형태로 발생할 수 있다고 알려져 있다. 따라서 안면신경 마비 환자의 치료에 있어서, 특히 HIV 감염에 대한 위험인자가 있는 경우 감별진단에 반드시 HIV 감염에 의한 안면신경 마비를 포함시켜야 한다. 저자는 HIV감염으로 인한, 심한 두통과 난청을 동반한 재발성 안면신경 마비 환자를 경험하였으므로 이를 문헌고찰과 함께 보고하는 바이다. Peripheral facial palsy has been considered as one of the neurologic complications of HIV infection, but the reported cases in the literature are rare. It is more common in the earlier stage of HIV infection due to the primary damage by HIV or to the secondary infection by Varicella-Zoster virus. So HIV infection should be included as a possible etiology of facial palsy, especially in the high-risk patients. In this paper, I report a case of 38-year old patient with recurrent facial palsy which was accompanied with severe headache and hearing loss as a primary manifestation of HIV infection.
조창건,지준혁,이은경,김보해,송재준 대한이비인후과학회 부산,울산,경남 지부회 2013 임상이비인후과 Vol.24 No.1
Background and Objectives:The mechanism of subjective tinnitus was not identified clearly. The goal of this study is to evaluate the somatization symptoms in subjective tinnitus patients and to define the relationship be-tween tinnitus and somatization symptoms. Materials and Methods:A total of 107 patients who were diagnosed as subjective tinnitus were included. Somatization subscales from Symptoms Check List-90-Revision (SCL-90-R) were administered to patients for the evaluation of somatization symptoms. Tinnitus handicap inventory and the subjective patterns of tinnitus by visual analogue scales were also assessed. Correlation analysis between somati-zation scores, THI scores and the VAS scores were performed. Results:Among the total number of tinnitus pa-tients, there were 18 patients (16.8%) over mild somatization symptoms. Significant correlation between somati-zation scores and THI scores was observed, especially in the moderate or severe tinnitus group. The results of relationship between somatization scores and 4 items of VAS scores, loudness and effect on life of tinnitus were significantly related to the somatization scores. Conclusions:We found the positive correlation between subjec-tive tinnitus and somatization symptoms. Subjective tinnitus may be a somatization symptom and it seems neces-sary to consider somatization disorder in management of tinnitus patients.
중이수술 후 대상포진 바이러스 재활성에 의한 지연성 안면신경 마비
조창건 대한이비인후과학회 2008 대한이비인후과학회지 두경부외과학 Vol.51 No.9
Herpes viral reactivation is thought to be an important etiologic factor in the development of post-operative delayed onset of facial paralysis. The authors present a case of herpes zoster oticus that occurred as a consequence of middle ear and mastoid surgery. The patient was initially misdiagnosed as iatrogenic facial paralysis and treated with oral steroid only. The final diagnosis of herpes zoster oticus was made by the development of herpetic auricular eruption with severe otalgia and the results of positive serological tests. Clinical features, diagnosis and management of this rare case are presented and discussed. (Korean J Otorhinolaryngol-Head Neck Surg 2008;51:829-32)
Evaluation of Anxiety and Depressive Levels in Tinnitus Patients
조창건,Jun Hyuk Chi,Jae-Jun Song,Eun Kyeong Lee,Bo Hae Kim 대한청각학회 2013 Journal of Audiology & Otology Vol.17 No.2
Background and Objectives: The aims of this study were to evaluate the relationship between tinnitus and the level of anxiety and depression experienced by subjective tinnitus patients, and to determine the effect of the level of anxiety and depression to the results of tinnitus treatment. Subjects and Methods: A total of 104 patients were included in this study. All the patients conducted Tinnitus Handicap Inventory (THI), Beck Depression Inventory (BDI), State Trait Anxiety Inventory 1, 2 (STAI 1, 2) to evaluate their psychometric properties. The subjective patterns of tinnitus before and after treatment were assessed through questionnaires. Results: Significant correlation between THI scores and BDI, STAI 1, 2 scores were observed in the moderate and severe tinnitus group. The patients were classified into two groups depending on their THI scores, and also classified into two groups according to BDI, STAI 1, 2 results. Analysis of differences after treatment indicated significantly improved VAS scores after treatment in all groups. Conclusions: The subjective level of tinnitus is significantly related with depression and anxiety symptoms when inconvenience caused by tinnitus was moderate or over. Assessments on tinnitus after treatment appeared to have improved significantly regardless of the severity of tinnitus, level of depression or anxiety disorder.
조창건 대한이비인후과학회 2015 대한이비인후과학회지 두경부외과학 Vol.58 No.6
Otitis media (OM) is one of the most common inflammatory illnesses in the pediatric population. OM is a multifactorial disease that develops as a result of complex interactions between bacterial infection, environmental risk factors, and host genetic factors. The high prevalence and recurrence of OM, coupled with the risk of developing hearing loss have meant that research to understand the mechanisms of OM and identify new therapeutic measures is urgent. Various experimental animals such as chinchilla, guinea pig, gerbil, rat and mouse have been used to investigate the pathogenesis and treatment of OM. Also, a lot of methods have been introduced to induce OM in animals including obstruction of E tube and direct injection of otopathogens into the middle ear. Recently there has been an increase in the use of the mouse for OM research due to the ability to easily manipulate their genetic components. The use of animal models has enabled researchers to identify a number of molecular mechanisms involved in the development of OM. Despite the real progresses obtained from animal models of OM, however, there are still several limitations to using them for OM research. In this review article, various animal models that have been introduced to investigate the pathogenesis of OM will be discussed briefly.
조창건,조재현,정정래,박재용 대한이비인후과학회 2004 대한이비인후과학회지 두경부외과학 Vol.47 No.5
Cholesterol granuloma of the paranasal sinus is a rare condition. It is rarely diagnosed preoperatively, as corect diagnosis depends on play significant roles in its pathogenesis. We have experienced a case of cholesterol granuloma that had developed in the frontal and the ethmoid sinuses, which was managed sucesfully by transnasal endoscopic marsupialization. We report this case with a lite-rature review.