PA-10 : STUDIES ON THE ESSENTIAL AMINO ACID RESIDUES OF BamHI ENDONUCLEASE AND THEIR ROLES

조진만,권세창,김주훈,조영동 한국생화학분자생물학회 (구 한국생화학회) 1987 추계학술대회집 Vol.- No.-

Pharmacokinetic and Pharmacodynamic Study Determines Factors Affecting Blood Pressure Response to Valsartan

조진만,임성빈,Hui Jin,손일석,황희정,박창범,진은선,Chong Jin Kim 대한고혈압학회 2012 Clinical Hypertension Vol.18 No.3

Background: Valsartan is an angiotensin II receptor blocker and is used for patient with hypertension. Although response to valsartan varies each individual, there is no study about factors affecting the variability of valsartan response. Methods: To investigate the effects of valsartan on the baseline characteristics of blood pressure, single group, open label, pre- and postcomparison clinical study was conducted. Total 21 male Korean volunteers were enrolled. Each subject was administered no drugs in first period and valsartan 80 mg (Diovan HCT) in second period. For pharmacodynamic analysis, 24 hours blood pressure changes were monitored by ambulatory blood pressure monitoring. Twenty-four hour blood pressure changes were matched to valsartan concentration and analyzed by correlation analysis. Changes in blood pressure pattern were also analyzed. Subjects were divided into responder, non-responder, and reverse responder according to pre- and post- 24 hours blood monitoring results. For determination of pharmacokinetic parameters, plasma concentration of valsartan was measured by a validated ultra-performance liquid chromatography-tandem mass spectrometry method. Pharmacokinetic parameters including area under the plasma concentration versus time curve from 0 hour to the last measurable concentration (AUCt), area under the plasma concentration versus time curve extrapolated to infinity, maximum plasma concentration (Cmax), and time required to reach maximum plasma concentration (Tmax) were calculated by noncompartmental models in the BA-CALC 2008 program ver. 1.0.0. Results: There were no significant associations between blood pressure changes and pharmacokinetic parameters of valsartan. Blood pressure pattern change analysis showed significant results. For AUCt, total amount of absorbed valsartan was 25,808 ± 6,863.0 ng․hr/mL , 20,683 ± 8,782.7ng․hr/mL, and 12,502 ± 5,566.6 ng․hr/mL in responder, non-responder, and reverse responder, respectively (p = 0.041). In Cmax, maximum concentration of valsartan was 4,314 ± 1,522.6 ng/mL, 2,588 ± 1,273.9 ng/mL, and 2,056 ± 1,075.5 ng/mL,respectively. Conclusions: These results showed that response to valsartan was not associated with blood concentration in healthy volunteers and changes in blood pressure patterns to valsartan might be associated with the amount of drugs which are absorbed to subjects.

위성방송 수신용 스마트카드에서의 직불 기능 고찰 ( Direct Debit function for Smart Card on DBS )

조진만,조현숙 대한전자공학회 1997 대한전자공학회 학술대회 Vol.1997 No.1

우리 나라 잠재수명 손실년수에 관한 연구 : Focus on Alcohol

조진만,임달호 한국응급구조학회 1999 한국응급구조학회지 Vol.3 No.1

Objectives: This study sought to examine the impact of alcohol use and misuse on mortality in korea during the 1991-l997. Methods: Alcohol-Related Disease Impact estimation software and Korea vital statistics data were used to calculate alcohol related-mortality, mortality rates, and YPLL(years of potential life lost). The major findings are as follows : An estimated 23,528 Korean died during 1997 from causes related to alcohol. Such deaths accounted for 17,052(12.60%) of all deaths for men and 6,206(5.88%) for women. Motor vehicle accidents were major contributors to the total estimated number of alcohol related deaths and years of potential life lost before age 65. Alcohol related mortality rates were significantly higher for men. For men, major causes of the deaths were motor vehicle accidents(4,147 deaths, 17.90 per 100,000 population), cancer of the stomach(1,467 deaths,16.60 per 100,000 population) and chronic liver diseases and cirrhosis(1,233 deaths, 13.10). For women, the largest contributors to alcohol related mortality were motor vehicle accidents(1,509 deaths, 6.61), cerebrovascular diseases(1,114 deaths, 11.3) and cancer of the stomach(810 deaths, 8.24). Kleinman's method was used for obtaining on regional(Dongs, ups and Myons) differential of the alcohol related mortality in 1995, In general, The alcohol-related death rate for men was significantly higher than that for women, and the rate for ups and myons was significantly higher than that for dongs. During 1997, approximately 356,667(male: 282, 510, female: 74, 157)YPLL to age 65 and 572,708(male:424,338, female:148,370)YPLL to life expectancy were attributable to alcohol related causes. Men accounted for 79% of the total YPLL to age 65 and 74% of the total YPLL to life expectancy The major contributors to these alcohol related years lost were the diagnostic categories of unintentional injuries. Particullary, In male Motor vehicle accidents and accidental drowning-YPLL are considerably higher for other causes. Male-female YPLL differentials were greatest for mental disorder. Male-female mean-YPLL to age 65, accidental drowning(male;36.47, female;37.67) is higher for other causes. In both sexes, The YPLL and M-YPLL to life expectancy was significantly higher than the YPLL and M-YPLL to life expectancy.

일부지역에서 구급차운전자의 구급차 안전운전 운행행태에 관한 연구

조진만,이병주 한국응급구조학회 1997 한국응급구조학회지 Vol.1 No.1

This is the first Korea study to evaluate the effects od the safety of ambulance driving and the occurrence of ambulance traffic accidents and to provide basic information for the description of various factors to reduce the ambulance traffic accidents. The major insturment of this study were Krean Self-Analysis Driver Opinionnaire. Questionnaire contains 8 items which measure driver's opinions or attitudes: driving courtesy, emotion, traffic law, speed, vehicle conditions, the use of drugs, high-risk behaviors, and human factors. To take the analysis of data, the total of 350 divers were investigated ambulance divers and others in Taejon City and others(6 City) from 1996. 1 July to 1996 31. July. The data were analyzed by the descriptive statistics and the logistic regression - path analysis - with SPSS and SAS package program. The result are as follows : 1. There was desirable attitude group(16.2%) and undesirable attitude group(17.6%) on safety ambulance driving. 2. It have suggested that risk factors of ambulance traffic accidents much affected with emotion and speed control on safety ambulance driving 〈Y(Accident) = -2.64 + 0.57 X₁(Emotion Control) + 0.30 X₂ (Seed control) + E〉 and motor traffic acident much affected with emotion control and high-risk behavior on safety driving 〈Y(Accident) = -1.11 + X₁(Emotion Control) + 0.29 X₂ (High-risk Behavior) + E〉 4. The primary emphassis of ambulance drivers was make us realized that improthatnt factors on safety ambulance driving were 1)making way for emergent ambulance, 2)driver's career, 3)the ability of emergency medical technics, and the knowledge or understanding of ambulance way difficult(or easy) of accdess. 5. Almost 96.6% of respondents have agreed to necessity of emergency medical technics for ambulance drivers. 6. Almost 94.6% of respondents have consented to necessity of emergency medical technicians for ambulance driving. 7. It have suggested that the proportion of traffic accident proprtion by desitable attitude group(16.7%) was much less than that of undesirable attitude group(30.8%) on safety ambulance driving(P<0.05)/ Ps) Accidents are unplanned, unforesen incidents which can Bead to harmful or unfortunate outcomes, Collisons are not accidents, since the basic cause of the majority of collisons invovles high-risk human behavior. Although there are many factors which contribute to accident causation, four basic factors seem to predominate in most traffic related situations. These four factors include: the human factor, the vehicle factor, the environmental factors and destination factor(Peto G. et at. 1995).

The Dokdo/Takeshima Dispute between Korea and Japan: Understanding the Whole Picture

조진만,김희민,최준영 인하대학교 국제관계연구소 2009 Pacific Focus Vol.24 No.3

n the past, most studies on territorial disputes have been in the discipline of history and international law. In this paper, we expand the debate by adopting a utility-theory approach to the issue of Dokdo/Takeshima. We introduce two different types of utility functions over the disputed islet, and show how moving from one to the other can alter the outcome of the dispute. We conclude: 1) utilizing historial and/or legal argument alone will not resolve the Dokdo/Takeshima dispute; 2) the different mixture of two different types of utilities change the outcome of the debate; and 3) the current configulation of preference/utilities among Koreans and Japanese over the issue of Dokdo/Takeshima will never allow mutually satisfactory negotiated solutions to the dispute. Overall our diagnosis and prediction are pessimistic.

모바일 지급결제의 시장 현황 및 표준화 동향

조진만,김수형,문기영,장종수,손승원,Cho, J.M.,Kim, S.H.,Moon, K.Y.,Jang, J.S.,Sohn, S.W. 한국전자통신연구원 2005 전자통신동향분석 Vol.20 No.1

모바일 지급결제 서비스는 개인이 휴대전화나 PDA 등 이동통신기기를 사용하여 자금이체나 상거래 대금의 결제 등에 이용하는 서비스를 말한다. 1990년대 후반부터 선을 보인 모바일 지급결제 서비스는 현재 최신의 IT 기술과 접목되어 다양한 환경에서 다종의 지급결제 방식으로 서비스되고 있는 추세에 있다. 그러나 모바일 지급결제 서비스 사업자가 시작 단계에서 호환성 문제를 고려하지 않고 서비스를 개시하여 사용자의 편의성과 투자 효율성을 높이기 위해 필요한 모바일 지급결제 표준화 과정에서 어려움을 겪고 있다. 본 고에서는 모바일 지급결제의 정의 및 분류, 국내외 시장현황, 그리고 표준화 대상이되는 핵심기술들과 표준화 동향에 대해 살펴보고자 한다.

연구논문 : 선거품질 평가와 선거관리위원회에 대한 신뢰

조진만,김용철,조영호 한국의회발전연구회 2015 의정연구 Vol.21 No.1

본 연구는 선거품질에 대한 유권자의 인식이 선거관리위원회에 대한 신뢰에 어떠한 영향을 미치는가를 설문조사 자료를 토대로 경험적으로 분석하고 있다. 본 연구의 결과, 절차적·내용적·결과적 차원의 선거품질 모두 선거관리위원회에 대한 신뢰에 통계적으로 유의미한 영향을 미치는 것으로 나타났다. 그리고 절차적·결과적 선거품질보다는 결과적 선거품질이 선거관리위원회에 대한 신뢰에 상대적으로 더 중요한 영향을 미치는 것으로 나타났다. 이와 같은 본연구의 결과는 향후 선거관리위원회가 절차적·내용적 차원의 선거품질뿐만아니라 결과적 차원의 선거품질을 제고시킬 수 있는 노력들을 적극적으로 전개할 필요가 있다는 점을 시사한다.

위성방송의 제한수신 서비스를 위한 스마트 카드 기술 ( SmartCard Technique for Access Control of DBS using Koreasat )

조진만,은성경,조현숙 한국통신학회 1996 한국통신학회 학술대회논문집 Vol.- No.-

위성방송의 제한수신 서비스를 위한 스마트카드 기술 ( Smart Card Technique for Access Control of DBS using Koreasat )

조진만,은성경,조현숙 대한전자공학회 1996 대한전자공학회 학술대회 Vol.1996 No.1