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조준훈,최윤라,이승은 대한병리학회 2012 Journal of Pathology and Translational Medicine Vol.46 No.2
Background: The amplification of murine double minutes (MDM2) is the primary feature of well-differentiated liposarcomas (WDLPS) and dedifferentiated liposarcomas (DDLPS), while DDIT3 rearrangement is the main one of myxoid liposarcomas (MLPS). Our aim was to evaluate the added value of MDM2 amplification and DDIT3 rearrangement in making a diagnosis and classifying lipogenic tumors. Methods: Eighty-two cases of liposarcoma and 60 lipomas diagnosed between 1995 and 2010 were analysed for MDM2 amplification and DDIT3 rearrangement using a fluorescence in situ hybridization (FISH). The subtypes of liposarcoma were reclassified according to the molecular results, whose results were reviewed with an analysis of the relevant histologic and immunohistochemical findings. Results: One case of lipoma (1.67%) was reclassified as a WDLPS. Of the liposarcomas, 13.4% (16/82) were reclassified after the molecular testing. Five cases of MLPS were reclassified as four cases of DDLPS and one case of myxoid lipoma. Two cases of WDLPS were reclassified as one case of spindle cell lipoma and another case of myxofibrosarcoma. Four cases of DDLPS were reclassified as two cases of leiomyosarcoma, one case of angiomyolipoma and another case of fibroinflammatory lesion. Of the six cases of pleomorphic liposarcoma, five were reclassified as DDLPS. Conclusions: In our series, a critical revision of diagnosis was found at a rate of 3.5% (5/142) after a review of the lipomatous lesions. The uses of molecular testing by MDM2 and DDIT3 FISH were valuable to make an accurate subtyping of liposarcomas as well as to differentiate WDLPS from benign lipomatous tumor.
조준훈,강명수,김경미 대한위암학회 2016 Journal of gastric cancer Vol.16 No.1
Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is one of the four subtypes of gastric carcinoma (GC), as defined by the novel classification recently proposed by The Cancer Genome Atlas. EBVaGC has several clinicopathological features such as longer survival and higher frequency of lymphoepithelioma-like carcinoma (LELC) and carcinoma with Crohn’s disease-like lymphoid reaction that distinguish it from EBV-negative GC. The intensity and pattern of host cellular immune response in GC have been found to significantly correlate with the prognosis of patients with GC, suggesting that immune reaction and tumor microenvironment have critical roles in the progression of GC, and in particular, EBVaGC. Here, we reviewed the cellular and molecular mechanisms underlying prominent immune reactions in patients with EBVaGC. In EBVaGC, deregulation of the expression of immune response-related genes promotes marked intra-or peritumoral immune cell infiltration. The expression of programmed death receptor-ligand 1 is known to be increased in EBVaGC, and therefore, it has been proposed as a favorable prognostic factor for patients with EBVaGC, albeit some data supporting this claim are controversial. Overall, the underlying mechanisms and clinical significance of the host cellular immune response in patients with EBVaGC have not been thoroughly elucidated. Therefore, further research is necessary to better understand the role of tumor microenvironment in EBVaGC.
가스터빈 초기 설계 단계의 시스템 타당성 평가를 위한 공력 성능, 이차 유로 및 열전달 통합 해석 프로그램 개발
조준훈(Joonhoon Cho),임병권(Byungkwon Im),민규빈(Gyubin Min),박영준(Youngjun Park),홍종섭(Jongsup Hong) 대한기계학회 2021 大韓機械學會論文集B Vol.45 No.2
가스터빈의 효율을 높이기 위하여 터빈 입구 온도 상승이 필요하나 고온 환경에서 가스터빈 구성품의 수명 및 안정성 등을 보장하기 위하여 이차 유로 유동을 통한 냉각이 필요하다. 이차 유로에 의한 냉각 성능과 터빈 입구 온도는 상충 관계에 있어 적절한 냉각 유량에 대한 판단이 필요하다. 이에 대한 판단은 전반적 시스템 타당성을 평가하는 초기 설계 단계에 이루어지므로, 최적화된 이차 유로 설계 및 성능, 열전달 특성 등을 종합하여 해석할 수 있는 기술이 필요하다. 본 연구에서는 주 유로 유동 해석 및 이차 유로 유동 네트워크 해석, 2차원 축 대칭 열전달 해석 기술을 연계하여 해석하는 기술을 개발하고, 예제 터빈에 대한 해석을 수행한다. Increasing the temperature of working fluid is necessary to increase the efficiency of a gas turbine, although it is essential to cool down the system with cooling air to ensure the life expectancy and stability of the gas turbine component in the high temperature environment. Because the flow rate of cooling air can decide the performance of a gas turbine, a proper amount of cooling air should be considered carefully. Therefore, an integrative technology that can simultaneously analyze the aerodynamic performance, secondary air system, and thermal/structural characteristics is necessary for the initial design stage. In this study, we develop the algorithm, which is conjugating aerodynamic analysis, flow network analysis for secondary air system, and 2D axisymmetric heat transfer analysis, and analyze an example turbine.
Adenocarcinoma of the minor salivary gland with concurrent MAML2 and EWSR1 alterations
최상준,조준훈,이승은,백정환,김이경,김형진,고영혜 대한병리학회 2021 Journal of Pathology and Translational Medicine Vol.55 No.2
Salivary gland tumors are histologically diverse, and each entity has distinctive histopathological and molecular features. We report two cases of salivary gland tumors with unique histological and molecular findings, which have not been documented previously. The tumors were located in the base of the tongue in both patients. Most tumor cells were arranged in cords and nests, giving a trabecular-like appearance. Focally, glandular structures with intraluminal mucin and perivascular pseudorosette-like configurations were identified. Tumor cells had eosinophilic to clear cytoplasm, and showed mild nuclear atypia. They were positive for pancytokeratin and negative for S-100, p63, c-KIT, androgen receptor, and neuroendocrine markers. Multiple foci of capsular or lymphovascular invasion were identified, but the Ki-67 labeling index was low (< 5%). Fluorescence in situ hybridization revealed concurrent alterations of MAML2 and EWSR1 gene. Further investigations with a larger number of cases with similar histological and molecular features will accurately classify this tumor.
임유진,윤상은,조준훈,김다래,정철원 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3
Erdheim-Chester disease (ECD), also known as non-Langerhans cell histiocytosis, is a multi-systemic disease with unclear pathogenesis. Based on a small number of case studies, pegylated interferon-α (PEG-IFN-α) has been used as the front-line treatment option. However, there are limited data regarding administration of ropegylated-interferon α-2b (ROPEG-IFN-α 2b) for ECD patients. Herein, we report two cases of severe ECD treated with two types of PEG-IFN-α. One patient with heart and skeleton involvement and BRAF V600E mutation was treated with weekly PEG-IFN-α 2a. Another patient with bone involvement and no BRAF V600E mutation was administered monthly ROPEG-IFN-α 2b. The two types of PEG-IFN-α showed excellent disease control, excellent survival outcomes, and manageable toxicities in ECD patients. These results suggest that ROPEG-IFN-α 2b could be used equivalently to PEG-IFN-α 2a for management of advanced ECD.
Feasibility of Circulating Tumor DNA Analysis in Patients with Follicular Lymphoma
윤상은,신승호,남대근,조준훈,김원석,김석진 대한암학회 2024 Cancer Research and Treatment Vol.56 No.3
Purpose The feasibility of sequencing circulating tumor DNA (ctDNA) in plasma as a biomarker to predict early relapse or poor prognosis in patients with follicular lymphoma (FL) receiving systemic immunochemotherapy is not clear. Materials and Methods We sequenced DNA from cell-free plasma that was serially obtained from newly diagnosed FL patients undergoing systemic immunochemotherapy. The mutation profiles of ctDNA at the time of diagnosis and at response evaluation and relapse and/or progression were compared with clinical course and treatment outcomes. Results Forty samples from patients receiving rituximab-containing immunochemotherapy were analyzed. Baseline sequencing detected mutations in all cases, with the major detected mutations being KMT2C (50%), CREBBP (45%), and KMT2D (45%). The concentration of ctDNA and tumor mutation burden showed a significant association with survival outcome. In particular, the presence of mutations in CREBBP and TP53 showed poor prognosis compared with patients without them. Longitudinal analysis of ctDNA using serially collected plasma samples showed an association between persistence or reappearance of ctDNA mutations and disease relapse or progression. Conclusion Analysis of ctDNA mutations in plasma at diagnosis might help predict outcome of disease, while analysis during follow-up may help to monitor disease status of patients with advanced FL. However, the feasibility of ctDNA measurement must be improved in order for it to become an appropriate and clinically relevant test in FL patients.