Helicobacter pylori 감염에 대한 13C- 요소호기검사의 임상적 유용성

조주영,이준성,김진오,이문성,황성규,김연수,배성한,심찬섭,조영덕,홍수진,문종호 대한소화기학회 1998 대한소화기학회지 Vol.31 No.5

Backgroued/Aims: The studies about roles of H. pylori in gastritis, gastric ulcer, duodenal ulcer and stomach cancer have been actively performed and clinically applied. Multiple tests are available for determining H. pylori infection. However, there is no ideal method for detecting H. pylori. This study was to compare the sensitivity and specificity of the most widely available tests for the diagnosis of H. pylori and to evaluate the clinical useflness of ^(13)C-urea breath test (UBT) that was developed recently as a noninvasive diagnostic method for the detection of H. pylori infection. Methods: Twenty one patients (mean age 46±21 years, 19 male, 2 female) including 6 patients with chronic active gastritis, 6 patients with gastric ulcer and 9 patients with duodenal ulcer were tested for H. pylori infection by ^(13)C-UBT and measurement of serum immunoglobulin G antibody levels, In addition antral biopsy specimens were obtained and used for rapid urese test, histology, culture, and polymerase chain reaction, In ^(13)C-UBT, we measured the expiratory ^(13)C-urea concentration of basal and 30 min value after oral ingestion of water mixed ^(13)C-urea, using MAT instrument of Isotechnika company. No patients received specific treatment for H. pylori before testing. Results: The ^(13)C-UBT was more sensitive and less specific than other tests for the diagnosis of H. pylori infection, but did not have statistical significance (p$gt;0.05). The ^(13)C-UBT had advantages, in that simple, noninvasive, short-time required. Moreover, it was no radiation expasure method unlike ^(14)C-UBT. However, it also had disadvantages because it required high cost and need at the mass speetrometer in test reading. Conclusions: ^(13)C-UBT is considered as one of the noninvasive methods for diagnosing H. pylori infection and evaluating the treatment efficacy after eradication of the bacteria in clinical use.

성폭력 피해 지적장애청소년에 대한 개입 사례연구

조주영 한국푸드아트테라피학회 2014 푸드아트테라피 Vol.3 No.1

생선뼈에 의해 형성된 기관 식도루에서 Fibrinogen-thrombin glue 로 치유된 기관 식도루 1예

조주영,이준성,이문성,심찬섭,유인환,어중건,전동하,이창후,강정협 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.1

Tracheoesophageal fistula is a rare disease of abnormal communication between esopha- gus and respiratory system. The common causes are the acquired origins in adult such as trauma, infection of the adjacent organs, malignant tumor, and foreign body. Among the traumatic origins, chemical drug, the procedure of the dilatation on the stenotic area, blunt trauma(fall, collisions), penetrating trauma(bullet, knife), and pressure injury are much more common than others. Recently, trauma and foreign body in the esophagus and bronchus are becoming the main cause of the tracheoesophageal fistula, however the frequency of the development of tracheoesophageal fistula caused by the infectious diseases is getting decreased. Fibrinogen-thrombin glue stimulates the healing process of the wound and the ulcer. We treated a 52-year-old male patient with nan-inalignant tracheoesophageal fistula, who had symtoms of pharyngolaryngeal and chest discomfort concomitant with a paroxysmal cough on swallowing food which were caused by fish bone. The diagnosis of tracheoesophageal fistula was made by the esophagogram, chest CT, and esop aecopy. By using the therapeutic endoscopy with an injection of the fibrinogen-glue, the tracheoesopeal fistula was obliterated completely with dramatic symptomatic improvement. Here we conqluded that this method would be the one of the best methods for the treatment of tracheoesophageal fistula.

Daratumumab 투여를 받은 다발성 골수종 환자에서 비예기항체 동정검사상 범응집 소견을 보인 1예

조주영,나현진,김대원,이은경,김진석,김현옥 대한수혈학회 2016 大韓輸血學會誌 Vol.27 No.2

Herein, we report a patient showing panagglutination in the unexpected antibody identification test after the administration of daratumumab. The patient was a 66-year-old woman who had undergone multiple cycles of chemotherapy and autologous peripheral blood stem cell transplantation for treating multiple myeloma; however, despite treatment, she had relapsed. Therefore, daratumumab, on clinical trials in Korea, started to be administered. After administration of daratumumab, the result of antibody screening test was positive, on the contrary to the result prior to the administration. Moreover, all positive reactions were shown in the antibody identification to the panel cells. After destroying CD38 antigens on the surface of RBCs using DTT, negative results were obtained. Daratumumab—a novel therapeutic human CD38 monoclonal antibody that can be used as targeted immunotherapy—is an FDA-approved drug for treating multiple myeloma. Because CD38 is expressed not only on myeloma cells, but also on red blood cells (RBCs), the use of daratumumab might lead to RBC agglutinations, and thereby resulting in false-positive results on the pre-transfusion tests. Therefore, caution is needed in case of a patient receiving daratumumab. Furthermore, additional test using DTT is required, especially when panagglutination was shown in the antibody identification test, as in this case. 저자들은 daratumumab 투여 후 비예기항체 동정검사상 범응집 소견을 보인 증례를 경험하였기에 보고하는 바이다. 환자는 66세 여성으로 다발성골수종 치료를 위해 항암화학요법과 자가조혈모세포이식 등을 시행하였으나 재발 소견을 보였다. 이에 국내에서 임상시험 중인 daratumumab을투여하기 시작하였다. Daratumumab 투여 전에는비예기항체 선별검사상 음성이었으나 투여 후에는 양성이었고, 비예기항체 동정검사상 범응집소견을 보였다. 이에 DTT를 처리하여 적혈구 표면의 CD38 항원을 파괴시킨 후 재검한 결과 음성으로 전환되었다. Daratumumab은 다발성골수종치료에 있어서 미국 FDA로부터 최초로 승인을받은 anti-CD38 단클론항체로서 골수종 세포에대한 표적치료가 가능하다. 그러나 CD38은 골수종 세포 뿐만이 아니라 적혈구에도 발현될 수 있기 때문에 수혈전검사에서 위양성 결과를 초래할수 있다. 따라서 다발성골수종 환자에서 daratumumab을투여하는 경우에는 수혈전검사 결과 해석에 주의를 해야 하며, 특히 비예기항체 동정검사상 범응집 소견을 보이는 경우에는 DTT 처리를 하여 추가적인 검사를 시행해야 할 것이다.

황사현상의 발생과 대처방안

조주영 한국공기청정협회 2004 空氣淸淨技術 Vol.17 No.1

조기위암에서 내시경 점막절제술/내시경 점막하 박리술의 확대적응

조주영,조원영,이태희,Cho, Joo-Young,Cho, Weon-Young,Lee, Tae-Hee 대한위암학회 2008 대한위암학회지 Vol.8 No.1

기관지천식 환자의 기관지 폐포세척세포의 H2O2 형성능

조주영,김용훈,정현태,박춘식 대한천식알레르기학회 1989 추계학술대회 초록집 Vol.1989 No.-

부분 간절제술로 급성간부전이 유도된 흰쥐에서 비장내 동종 간세포 이식

조주영,이준성,김홍수,김진오,이문성,황성규,김연수,심찬섭,조영덕,홍수진,천갑진,윤익진 대한소화기학회 1998 대한소화기학회지 Vol.31 No.5

Background/Aims: Various techniques of hepatocyte transplantation were actively studied as the alternatives to liver transplantation because of potential advantages including technical simplicity, low risk of operation and use of cells from a liver of single donor for multiple recipients, We investigated the effect of allogenic hepatocellular transplantation into spleen on the survival rate after 90% partial hepatectomy-induced acute hepatic failure in rats. Methods: Acute hepatic failure was induced by resection of all lobes except caudate lobe in Sprague-Dawley rats. Hepatocytes, isolated by collagenase perfusion of the liver via the portal vein, were transplanted into the spleen of rats after 90% partial hepatectomy (2.0×10^7 hepatocytes/rat). Results: There was significant difference in the survival rate between control group without treatment after 90% partial hepatectomy and transplanted group receiving intrasplenic allogenic hepatocellular transplantation after 90% partial hepatectomy. Engraftment and survival of transplanted hepatocytes were observed in spleen 2 days after transplantation. Conclusioas: We could observe significant improvernent of survival rate by intrasplenic hepatocellular transplantation in rats with 90% partial hepatectomy-induced acute liver failure. These results suggest that intrasplenic hepatocellular transplantation may be effective in the treatment of acute liver failure.

영상매체 성메세지와 청소년의 성반응 : 성태도와 성행동을 중심으로 Attitudes and Behaviors Toward Sex

조주영,김영희 대한가정학회 2004 Human Ecology Research(HER) Vol.42 No.3

The purpose. of this study was to investigate the effect of sexual messages in the d a on adolescents' attitudes and behaviors toward sex. Subjects of this study consisted of 488 high school students in Cheorpju City. The findings of this study were as follows; First, sexual messages in the media influenced-adolescents' attitudes toward sex. The more expure to sexual messages adolescents had more liberal and permissive attitude toward sex. Secondly, sexual messages in the media also effected adolescents' behaviors toward sex, as well. The less sexual messages that they were exposed to, they displayed less sexual relations and behavior. In particular, the number of sexual materials in mass media, variety of sexual messages, and types of school were significant factors in predicting adolescents' sexual intercome. The research suggested that sexual messages in the media definitely had an effect on adolescents' attitudes and behaviors toward sex. Therefore, it should be encouraged to take advantage of the television V chip and screening software for computers to reduce inappropriate access for adolescents.

에니어그램 발달수준과 관련된 개인·가족 요인

조주영,차윤희 한국에니어그램학회 2008 에니어그램연구 Vol.5 No.2