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비심장성 흉통을 가진 환자에서 식도 Scintigraphy 의 의의
조정곤(Jung Kon Cho),구철(Cheol Koo),유종선(Jong Seon Rew),윤종만(Chong Mann Yoon),김지열(Ji Yeoul Kim) 대한내과학회 1989 대한내과학회지 Vol.37 No.5
N/A In order to evaluate the diagnostic value of esophageal scintigraphy in patients with sustained angina like chest pain of noncardiac origin, we performed esophageal scintigraphy in 25 normal subjects and 25 patients with chest pain of noncardiac origin. All the patients who complained of chest pain were studied with exercise ECG and/or coronary angiography to exclude the cardiac origin. Esophageal transit time (ETT) was significantly longer in the patient group (19.4±15.1 sec) than in the control group (7.2±3.9 sce). Cases of abnormal transit time and pattern were 11/25 (44%) in the patient group and 2/25 (8%) in the contn1 group, respectively. Cases of the markedly prolonged transit time more than 40 sec were 8 (32%) in the patient group, but there were none in the control group. Abnormal patterns of esophageal transit were divided into two groups: incoordinate movement (24%) and adynamic movement (20%) of radioisotope. These results suggest that esophageal scintigraphy could be used as a diagnostic modality in angina like chest pain of noncardiac origin.
위암종에서 Epidermal Growth Factor Receptor 의 발현에 관한 연구 - 면역조직화학적 염색 및 in situ Hybridization -
조정곤(Jung Kon Cho),류도현(Do Hyun Rheu),최성규(Sung Kyu Choi),유종선(Jong Sun Rew),윤종만(Chong Mann Yoon),박창수(Chang Soo Park) 대한내과학회 1996 대한내과학회지 Vol.51 No.1
N/A Objectives: Gastric carcinoma is the leading cause of death among cancer patients in Korea. The etiologic factors of gastric carcinoma were suggested to chronic gastritis, genetic defect, food and environmental factor. Recently, the studies for oncogene and tumor marker have been actively performed to investigate the causes of gastric carcinoma. Epidermal growth factor receptor(EGFR) has homology in amino acids with c-erb B2 oncogene product. EGFR was identified in the placenta, chorionic villi and gastrointestinal mucosa. But it was more expressed in tumor cells, and it may be usedas a tumor marker. Methods: To investigate the correlation between EGFR and malignant potentiality in gastric carcinoma, we performed in situ hybridization of EGFR mRNA and immunohistochemistry of c-erb B2 and EGFR in 127 cases of formalin fixed paraffin embedded tissue sections of gastric carcinoma. Results: The positive reaction for c-erb B2, EGFR protein and EGFR mRNA was identified in the cytoplasm of tumor cells. The positive ratio was 44.196 in c-erb B2, 63.8% in EGFR, and EGFR mRNA was expressed in 72.4% of cases. The expression of c-erb B2 was not related with differentiation of cells, tumor size, invasiveness and metastasis. However the expression of EGFR and EGFR mRNA was related to the invasion of primary tumor and lymph node metastasis (p<.0.05). And expression of EGFR mRNA was increased in the advances of clinical stage. Conclusion: These above results suggest that the expression of EGFR mRNA is related with malignant potentiality of gastric carcinoma. EGFR mRNA might be used as tumor marker and prognostic factor of gastric carcinoma.
각종 간질환에서 혈청 Adenosine Deaminase 활성도
최성규(Sung Kyu Choi),양대현(Dae Hyun Yang),조정곤(Jong Kon Cho),박해옥(Hae Ok Park),박일종(Il Jong Park),범희승(Hee Seung Bom),류종선(Jong Seon Rew),윤종만(Chong Mann Yoon) 대한내과학회 1988 대한내과학회지 Vol.34 No.5
N/A To evaluate the clinical significance of serum ADA activity, serum ADA acitivities and their correlation with other liver function tests were analyzed in various hepatitic diseases, Sera of 30 normal adults, 18 patients with acute viral hepatitis R, 3 fulminant hepatitis, 13 chronic persistent hepatitis, 17 chronic active hepatitis, 47 liver cirrhosis, 15 primary hepatoma and 7 metastatic hepatoma were analyzed with colorimetric method of Guisti for serum ADA activity. The result obtained are as follows 1) In normal adults, the mean value of serum ADA activity is 18.84±4,00 U/L. 2) The mean value of serum ADA activity are 48,94±14.68 U/L in acute B viral hepatitis, 40.14±14.20 U/L in chronic persistent hepatitis, 56.02±3.61 U/L in chronic active hepatitis, 60.31±23.22 U/L in liver cirrhosis, 45. 82±21.09 U/L in primary hepatoma, 26.67±9.01U/L in metastatic hepatoma. There is significant difference between normal and various hepatic diseases. But there is no significant difference among various hepatic diseases. 3) There is no significant correlation between serum ADA activity and liver function test(AST, ALT, ALP) in various hepatic diseases. 4) In acute viral hepatitis B, serum ADA activity is decreased with time lapse. And as liver function test returns to normal, serum ADA activity is also normalized. 5) In one expired cases of fulminant hepatitis, serum ADA activity is decreased before death, while other liver function test (AST, ALT) are not reduced. But, in survived cases serum ADA activity and other liver function tests are not decreased for 3 weeks.
위내시경으로 (胃內視鏡) 진단된 각종 위질환 (胃疾患) 에서의 장상피화생의 (腸上皮化生) 유형에 관한 연구
윤종만(Chong Mann Yoon),박광숙(Kwang Sook Park),범희승(Hee Seung Bom),박일종(Il Chong Park),류종선(Jong Sun Rew),양대현(Dae Hyun Yang),조정곤(Jung Kon Cho) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
N/A To evaluate the significance of intestinal metaplasia as a guide for precancerous lesions in gastric cancer, we studied the frequency and subtypes of intestinal metaplasia in 189 patients including 64 cases of chronic gastritis, 45 with gastric ulcers and 80 with gastric cancer who underwent gastroscopic biopsies in the department of internal medicine of Chonnam Univerity Hospital. The results were the following: 1) The overall positivity of intestinal metaplasia in 189 patients with various gastric lesions was 57 percents with 47 percents in chronic gastritis, 62 percents in gastric ulcer and 61 percents in gastric cancer. 2) The positivity of intestinal metaplasia in gastric cancer in well differentiated types (69%) was not so higher than in undifferentiated types (48%). But the positivity of intestinal metaplasia in gastric cancer of intestinal type (84%) was higher than in gastric type (21%) with statistical significance (p<0.005). 3) The frequency of intestinal metaplasia showed increasing tendency with aging. 4) According to the Hematoxylin-Eosin, PAS and Alcian-Blue stain, intestinal metaplasia is divided into 3 subtypes. Type II enterocolic metaplasia is not detected in chronic gastritis but in only one case of gastric ulcer. The presence of enterocolic metaplasia is 20 out of 49 patients with gastric cancer, with 44 percents in intestinal type and 0 percent in gastric type. The result of this study suggests that type II. Benterocolic type of intestinal rnetaplasia plays a significant role as a precancerous lesion in intestinal type of gastric cancer.
위궤양에 대한 Teprenone ( Selbex ) 의 효과
윤종만(Chong Mann Yoon),범희승(Hee Seung Bom),최성규(Sung Kyu Choi),박일종(Il Chong Park),박해옥(Hae Ok Park),류종선(Jong Sun Rew),양대현(Dae Hyun Rang),조정곤(Jong Kon Cho) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
The balance of mucosal defensive factors and aggressive factors is important for ulcerogenesis. Gastrointestinal mucus is a complex glycoprotein which is secreted from variable types of cells in the gastrointestinal tract. Glycoprotein plays an important role as a mucosal defensive factor.We have treated 30 cases of endoscopically diagnosed gastric ulcers with teprenone (Selbex) for the evaluation of the therapeutic efficacy. Every patient was treated with teprenone 50 mg t.i.d. for 8 weeks and underwent endoscopic, clinical and laboratory assessments before and after 8 weeks of the treatment. Aiajor symptoms of gastric ulcer have been improved in 2 out :30 cases (83.4%) after 8 weeks of the medication with teprenone. While, the improvement of gastric ulcer evaluated by endoscopy was observed in 21 out of 30 cases (70.0%). No significant side effects were observed except a mild elevation of SGOT in one patient.
양대현,범희승,최성규,유종선,박해옥,조정곤,윤종만 대한소화기내시경학회 1988 Clinical Endoscopy Vol.8 No.1
The records of 34 patients with histologically proven pm-gastric cancer were reviewed from Chonnam University Hospital during the recent 6 year period, 1981, to 1986. The male outnumbered female in a ratio of 2.4:1.0. The peak incidence was 6th decade and mean age were 53.8 years in male, 48.7 years in female respectively. pm-gastric cancer was most often seen on the lesser curvature side, eapecially in the lower 1/3 of the stomach. Macroscopically, it can be divided into early-cancer-like type and Borrmann type. Early-cancer-like type was more frequent than Borrmann type. Early-cancer-like type IIc+III was most often seen with a rate of 20.6%, followed in the order of frequency by Borrman type II, early-cancer-like type IIc, IIa+IIc, and Ile+ IIa. The incidence of lymph node involvement was 26.4% and were related to the macroscopic types and/or histologic differentiation degrees. 5 cases out of 34 pm-gastric cancer expired during the follow up period, and their mean survival time was 32.8 months. The type of operation and the extent of resection were closely related to survival. Five year survival rate was 54.0%. These results shows the significance of the pm-gastrie cancer as a early simulating advanced cancer.
대장내시경으로 진단된 맹장을 침범한 Behcet 씨 증후군 1예
양대현,범희승,김세종,윤종만,박일종,박해옥,조정곤,최성규,정상우 대한소화기내시경학회 1987 Clinical Endoscopy Vol.7 No.1
Authors came acoss a case of Behcet's syndrome involving cecum. The patient was a 33-year-old female. Her chief complaint was right lower quadrant pain, Colonoscopy revealed several ulcerations the base of which was covered by thick whitish coat, They were surrounded by mulitiple nodular masses. Endoscopic biopsy showed noaspecific ulceration. The patient had a history of aphthous ulceration of mouth and external genitalia. So she was diagnosed to have Behcets syndrome. She underwent right hemicolectomy with tetminal ilectomy. We report this case with literiature review.