http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
혈관 생성 억제 제를 투여한 신생마우스 폐 조직에서 Retinoic acid의 세포자멸사의 억제
주선영 ( Sun Young Ju ),조경아 ( Kyoung Ah Cho ),유경하 ( Kyung Ha Ryu ),우소연 ( So Youn Woo ),박은애 ( Eun Ae Park ),조수진 ( Su Jin Cho ) 대한주산의학회 2008 Perinatology Vol.19 No.1
목적: Retinoic acid는 폐포 재생에 중요한 역할을 하는 것으로 알려져 있어서 미숙아의 기관지폐이형성중의 예방에 사용되고 있다. 기관지폐이형성중의 병태생리는 미숙한 폐의 내피세포와 외피세포의 세포자멸사를 일으킴과 관련이 있다. 이에 본 연구에서 VEGFR2 억제가 신생 폐에서 세포자멸사를 증가시키는지, 또 retinoic acid의 투여가 본 폐 발달 억제 동물모형에서 세포자멸사를 억제하는지 알아보고자 하였다. 방법: VEGFR2 억제제인 SU1498을 생후3일된 마우스에 주사하고, 폐포발달이 이루어지는 그 후 10일간 retinoic acid나 위약을 주사하였다. 형태학적인 분석을 하였고, 세표자멸사를 비교분석하기 위해서 TUNEL 염색과 Annexin V을 표지자로 FACS출 시행하였다. 자멸사한 세포를 확인하기 위해서 동일초점 현미경으로 분석하였다. 결과: SU1498를 주사한 마우스에서 폐포면적과 평균폐포용적이 의미 있게 감소하였다. 세포자멸사도 약 3배 의미 있게 증가하였다. 자멸사한 세포는 내피세포와 상피세포에 분포하였다. Retinoic acid를 주사한 약 50%의 세포자멸사가 감소하였고, 형태학적으로 정상에 가까운 폐포 발달이 유지되었다. 결론: VEGFR2 억제를 하면 내피세포와 상피세포의 세포자멸사가 증가되면서 폐 발달이 저해되었다. 이어서 retinoic acid를 주사하면 세포자멸사가 억제되어 폐 발달유지에 도움이 되었다. 이러한 retinoic acid에 의한 세포자멸사의 억제가 기관지폐이형성증 예방에 기여할 것으로 추정된다. Background: Retinoic acid is known to play a role in alveolar regeneration and is used in the prevention of bronchopulmonary dysplasia (BPD) in premature infants. Many factors involved in the pathogenesis of BPD induce apoptosis of the endothelium and epithelium of the premature lung. We hypothesized that VEGFR2 inhibition would increase apoptosis in the newborn lung and retinoic acid would decrease apoptosis in our model of inhibited lung growth. Material and Methods: SU1498, a VEGFR2 inhibitor or vehicle was given to three-day-old mice. Subsequent retinoic acid or vehicle injection was given for ten days for the duration of alveolarization. Morphometric analyses were performed. Apoptosis was assessed with TUNEL staining and Annexin V staining. Co-localization of apoptotic cells with endothelial and epithelial cells was performed. Results: SUI498 injection reduced alveolar surface area and mean alveolar volume in newborn mice. Apoptosis was increased by three-fold in SU1498 injected mice. Apoptotic cells co-localized to endothelial and epithelial cells. Retinoic acid significantly reduced the degree of apoptosis by 50% in SU1498 injected mice and maintained lung development. Conclusion: VEGFR2 inhibition caused an arrest in lung development accompanied by an increase in apoptosis of endothelial and epithelial cells of the neonatal lung in mice. Subsequent retinoic acid treatment reduced apoptosis and we speculate that retinoic acid may preserve lung growth in bronchopulmonary dysplasia by inhibiting apoptosis in the neonatal lung.
조주영 ( Ju Yeong Jo ),조수진 ( Su Jin Ju ),송희상 ( Hii Sang Song ) 조선대학교 치의학연구원 2014 Oral Biology Research (Oral Biol Res) Vol.38 No.2
Despite significant improvements in medical treatments, infective endocarditis remains a very serious health problem with considerable morbidity and mortality. Indeed, the frequency of severe endocarditis has increased in recent years, particularly in association with antibiotic-resistant pathogens. Accordingly, infective endocarditis constitutes a major challenge for clinicians and a considerable burden for the health-care system. In addition, dental disease has long been associated with increased prevalence of infective endocarditis. Many reports have demonstrated that antibiotics given before a dental procedure can reduce the risk of bacteremia from oral disease. Here, we review recent treatments for prophylaxis of infective endocarditis before dental procedure.
정상임신 및 임신성 당뇨임신의 제대혈내 adiponectin 농도에 관한 연구
조아라 ( Ah Ra Cho ),김영주 ( Young Ju Kim ),전선희 ( Sun Hee Chun ),조수진 ( Su Jin Cho ),박은애 ( Eun Ae Park ),박미혜 ( Mi Hye Park ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.9
Objective: To investigate the effect of intrauterine environment on adiponectin level in cord blood through comparison of normal pregnancy group and gestational diabetes group. Methods: This cross sectional study included women with: normal pregnancy (n = 204); and patients with gestational diabetes mellitus (GDM) (n = 204). Among GDM patients, 118 were managed with diet alone and 86 were insulin requiring. Cord serum adiponectin concentration at birth was measured by enzyme-linked immunosorbent assay. Results: Cord serum adiponectin concentration was higher in GDM treatment pregnancies compared with normal pregnancies (P = 0.02). Cord serum adiponectin concentration was higher in female compared with male fetuses both normal and gestational diabetes pregnancies (P = 0.04, P = 0.03). In normal pregnancies, cord serum adiponectin concentration was positively correlated with gestational age (r = 0.2374, P < 0.02). In normal pregnancies, cord serum adiponectin concentration did not correlated with birth weight (r = -0.05, P > 0.05). Cord serum adiponectin concentration was not different between only diet treated women and insulin requiring women in GDM (P > 0.05). Conclusion: Sex dimorphism for adiponectin and the change of adiponectin in GDM off springs, first appear in utero. Higher adiponectin levels in females or GDM off springs reflect increased adiposity of the fetuses.
돼지 $\beta$-Casein 유전자의 3' 말단 부위의 cis-Acting Element가 유선 상피 세포내의 발현에 미치는 영향
이휘철,김병주,변승준,이승훈,김민지,정희경,이현기,조수진,장원경,박진기,이풍연,Lee, Hwi-Cheul,Kim, Byoung-Ju,Byun, Sung-June,Lee, Seung-Hoon,Kim, Min-Ji,Chung, Hee Kyoung,Lee, Hyun-Gi,Jo, Su-Jin,Chang, Won-Kyong,Park, Jin-Ki,Lee, Poong 한국동물번식학회 2008 Reproductive & developmental biology Vol.32 No.3
Tissue-specific and temporal regulation of milk protein gene expression is advantageous when creating transgenic animal that produces foreign protein into milk. Gene expression, i.e. protein production, is regulated not only by promoter strength but also mRNA stability. Especially, poly A tail length by polyadenylation affects in vivo and in vitro mRNA stability and translation efficiency of the target gene. In the present study, nucleotide sequence of 3'-UTR was analyzed to evaluate the effects of mRNA stability on the target gene expression. Based on the poly A signal of 3' -untranslated region (UTR), nucleotide sequences of putative cytoplasmic polyadenylation elements (CPEs) and downstream elements (DSEs: U-rich, G-rich, GU-rich) were analyzed and used to construct 15 luciferase reporter vectors. Each vector was transfected to HC11 and porcine mammary gland cell (PMGC) and measured for dual luciferase expression levels after 48 hours of incubation. Luciferase expression was significantly higher in construct #6 (with CPE 2, 3 and DSE 1 of exon 9) and #11 (with CPE 2, 3 and DSE 1, 2 and 3 of exon 9) than construct #1 in the PMGC. These results suggest that expression of target genes in PMGC may be effectively expressed by using the construct #6 and #11 on production of transgenic pig. 형질 전환 동물 생산에는 조직 및 시기 특이적 발현 조절이 가능하다는 장점 때문에 유즙 내로 외부 유전자를 발현시키는 시스템이 널리 이용되고 있다. 유전자 발현 즉, 단백질 생산은 프로모터의 강도뿐만 아니라 mRNA의 안정성에 의해서도 조절된다. 특히, polyadenylation에 의한 poly A의 길이는 in vivo와 올 in vitro에서 mRNA 안정성 및 목적 유전자의 번역효율에 영향을 준다. 본 연구에서는 이러한 mRNA 안정성이 목적 유전자의 발현에 미치는 영향을 알아보기 위해 3'-UTR 염기 서열을 분석하였다. 이 3'-untranslated region(UTR) 내의 poly A signal을 기준으로 putative cytoplasmic polyadenylation element(CPE) 부위와 downstream elements(DSE: U-rich, G-rich, GU-rich)의 염기 서열을 분석하고, 각각의 element를 기준으로 15 종의 luciferase reporter vector를 제작하여, 생쥐 유선 세포주(HC11)와 돼지 유선 세포주(PMGC)에 각각 transfection시킨 후 48시간 동안 배양하고 luciferase 발현량을 분석하였다. PMGC의 경우, luciferase의 발현은 exon 9의 CPE 2,3 및 DSE 1을 포함한 #6 construct에서 유의적으로 높은 발현량을 보였으며, exon 9의 CPE 2, 3과 DSE를 모두 포함하고 있는 #11 construct에서도 유의적으로 높은 발현량을 보였다. 이러한 결과는 형질 전환 돼지 생산에 있어 #6 및 11 construct의 사용은 목적의 유전자를 효과적으로 발현시키는데 기여할 것으로 사료된다.
보건분야 우선순위 설정에 대한 외국 사례 비교 및 정책적 시사점
송현종 ( Hyun Jong Song ),강민선 ( Min Sun Kang ),조수진 ( Su Jin Cho ),정설희 ( Seol Hee Chung ),오주연 ( Ju Yeon Oh ) 한국보건경제정책학회 2008 보건경제와 정책연구 Vol.14 No.1
Efficient resource allocation is one of major challenge among the all nations because health care demand usually exceeds the available resources. Therefore, rationing and priority setting are necessary to allocate scarce resources effectively. However, discussions and studies about priority setting regarding health care are insufficient in Korea while rationing and priority setting in health care has been discussed among the European countries since the late 1980`s. This paper offers the comprehensive analysis of rationing and priority setting in major foreign countries and ultimately drives suggestions for Korea. The health care cost containment and the limitation on health care coverage are major motivation to start discussions about prioritization among the foreign countries. Those prioritizations are based on both clinical standards and social standards including disease severity, cost effectiveness, individual responsibility, etc. The levels of prioritization are federal governments, local governments, and individual organizations such as hospitals. Epidemiological and economical approaches are used as prioritization methods and recently medical technology evaluation is used for the prioritization in many countries. The participation of the general public is getting important in the priority setting at the same time. In conclusion, various stake holders and interest groups should be included for the priority setting in Korea to develop clear standards by common consent.
조산 임신부의 분만 전 생식기 Mycoplasmas 감염과 임신 및 신생아 예후에 관한 연구
정현경 ( Hyun Kyung Chung ),박소연 ( So Yun Park ),박미혜 ( Mi Hye Park ),김영주 ( Yong Ju Kim ),전선희 ( Sun Hee Chun ),조수진 ( Su Jin Cho ),박은애 ( Eun Ae Park ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.3
Objective We conducted this study to evaluate the relationship between genital Mycoplasmas infection in women who had preterm delivery and the neontal outcomes. Methods We studied 116 women with preterm delivery (gestational age, ranged from 24 to 37 weeks) and their 116 premature infants born at Ewha Womans University Mokdong Hospital from August 2009 to December 2010. Culture for genital Mycoplasmas or a polymerase chain reaction was performed in vaginal fl uid obtained from women who had preterm delivery. For perinatal outcomes, chorioamnionitis, funisitis and puerperal infection were analysed. We also evaluated the following neonatal data; birth weight, sex, small for gestational age, Apgar score, cord blood pH, ventilator care, hospital days, incidence of respiratory distress syndrome, bronchopulmonary dysplasia, sepsis, intraventricular hemorrhage and patent ductus arteriosus. Results Genital Mycoplasmas were isolated in 36.2% (42 of 116 patients). History of prior preterm birth was significantly higher and the cervical length at admission was significantly shorter in patients with genital Mycoplasmas infection ( P < 0.05). Perinatal outcomes according to the Mycoplasmas infection and the neonatal outcomes were not statistically different between study and control groups. The relative risk of respiratory distress syndrome and bronchopulmonary dysplasia were 1.55 (95% confidence interval [CI], 0.65-3.70), and 1.24 (95% CI, 0.42-3.67), respectively. Conclusion There is higher incidence of prior preterm birth and shorter cervical length in patient with genital Mycoplasmas infection. However, genital Mycoplasmas infection does not affect the neonatal outcomes