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RISS 인기검색어
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- 저자 : 조성원(SW Cho) (검색결과 4 건)
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강신명(SM Kang),조성원(SW Cho),김원자(WJ Kim),노영자(YJ Rho) 대한산부인과학회 1964 Obstetrics & Gynecology Science Vol.7 No.1
1. 여기에 보고한 2예중 하나는 해부학적분류에 가깝고 다른 하나는 병리 및 임상적분류에 속하는 경관임신들이었다. 2. 이 2예는 모두 술전에 진단이 붙지 못하고 예 1은 전행소파술을 받은 후의 완고한 출혈이었으므로 인공유산후경손상으로 인상되었고, 예 2는 절박유산, 그후 천연유산으로 인상되었다. 전자는 시험소파술후 질식자궁척출을 하였고 후자는 일차 소파 및 경내팩킹을 하였는데 모두 결과 양호하였다. 3. 예 1에 있어서 자궁척출술시 저자가 곤란을 당한 것은 출혈이 보통이상으로 많아서 술중 2,000cc의 수혈을 하였다. 경관임신 때는 정상체부임신때와 달라서 골반상과 특히 방광 및 직장부착부에 혈관증대, 확장 등의 생리적변화가 일어나 있어서 술시 박리곤란 내지 극심한 출혈이 나타난다고 착자는 생각되었다. 따라서 자궁척출시에도 시험소파때와 같이 다량의 혈액을 준비하고서 한다는 것은 역시 대단히 중요하며 이로써 모성사망율도 감소될 것이다. 내반이 확실히 퇴행되었을 때(천연유산등)는 출혈의 위험이 적을 것이라고 본다(예 3). : 자궁경관임신, 자궁경부임신, 자궁외임신.... 2 cases of Cervical pregnancy meeting the criteria of Paalman and McElin; One closed to anatomical proof, the other proved pathologically and suggested clinically have been reported. It was impossible to me to make correct diagnosis preoperatively on either cases. Cases I, who had previous curettage therapeutic abortion(8 weeks gestation) 5 days prior to the admission was treated as post D. & C. hemorrhage or cervical injury, in which performing repeated curettages and cervical packings followed by vaginal hysterectomy. Case II, with vaginal spotting of 7 days duration was treated as threatened abortion at 7 weeks gestation, later as missed abortion, in which carrying out single curettage and cervical packing successfully. The results of 2 cases were good despite of one encountered a stomy hemorrhage during the hysterectomy. I would like to emphasize and urge that even in performing the hystectomy for cervical pregnancy, large amount of blood should be prepaired and available just like performing for the trical of curettage before any treatment is initiated, because I have experienced unforgetable severe hemorrhage during the hysterectomy, requiring up to 2.000 c.c. of blood transfusions(case I); probably due to the physiologic changes in cervical pregncy unlike the corporeal pregnancy, causing unusual vascularization or varicoses over the pelvic floor or vesico & recto-cervical areas depend on the site of implantation. The placenta regression type such as terminated as missed abortion (case II), however will be less chance of bleeding.
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노영자(YJ Rho),조성원(SW Cho),구혜서(HS Koo),김원자(WJ Kim) 대한산부인과학회 1964 Obstetrics & Gynecology Science Vol.7 No.3
52세의 폐경기에 있는 부인에게 있어 악취가 심한 혈성 vaginal discharge가 2주일간 지속하였는데 그것이 아메바성으로 왔다는 것을 확인한 후 Diodoquin과 Hectalin 사용으로 완치된 1예를 보고하였다. A Case of Amebic Cervico-Vaginitis in 52 years old woman is reported. And this case is very rare, so a brief review on the literature is made.
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상피성난소암에서 p53 유전자변이 및 난소암의 발생기원에 관한 연구
남주현(CH Nam),송규영(KY Song),조성원(SW Cho),김종혁(JH Kim),김용만(YM Kim),목정은(JE Mok) 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.5
Although ovarian cancer is the most lethal tumor of the female genital tract, molecular mechanism of tumor development have not yet fully been understood. The loss of heterozygosity on chromosome 3, 6, 11 and 17 has been reported to occur frequently in ovarian cancer, suggesting the involvement of tumor suppressor gene inactivation in the development of ovarian cancer. I became clear that p53 tumor suppressor gene could be a prime target form genetic alteration in sporadic human malignancies such as lung, colo, brreast and ovary. Activating mutations seem to concentrate in a portion of the gene spanning codons 132-281, corresponding to exons 5-8, and do not seem to conform to a particular parttern, since they range from nucleotide substitution to deletions of variable length. The objectives of this study were to define the sites, nature and incidence of the mutations of p53 tumor supressor gene in epithelial ovarian cancer and the stage(early or late event) of the genetic alterations by comparing these mutations in primary tumors with those in metastases. Using polymerase chain reaction with primers form exon 5, 6, 7 and 8 followed by direct DNA sequencing technique, we analysed 61 fresh frozen ovarian cancer samples(primary tumor and metastases) from 23 patients with epithelial ovarian cancer who were surgically treated in Asan Medical Center. Twelve point mutations were indentified from five(21.7%) of the patients tested. Mutations were shown in exons 5 and 8, but no preferential pattern of nucleotide substitution could be observed. In the cases showing twon or more sites with mutation(case 7, 10, 16) the natures of nucleotide substitution in DNA from different sites within the same patient were identical. This suggests that ovarian carcinomas have unifocal orgin. And it was noticeable that mutations were observed in all primary lesions(ovaries), but in only a few sites of metastatic lesions, suggesting that p53 mutations may occur late during ovarian cancer evolution.
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다중중합효소연쇄반응과 써던 블롯팅을 이용한 근이영양증 ( DMD ) 의 진단
이숙환(SH Lee),한정희(JH Han),곽인평(IP Kwak),차광은(KE Cha),조성원(SW Cho),한세열(SY Han),김남근(NK Kim),박찬(C Park),차광열(KY Cha) 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.5
Duchene and Becker muscular dystrophy(DMD/BMD) results from mutations in the dystrophin gene, and enormous genetic locus that spans more than two million base paris of DNA on the human X chromosome. Some 60% of DMD patients exhibit deletions, which can be found by cDNA hybridization or, were recently, by polymerase chain reaction analysis. We have used the multiplex PCR to identify deletion mutations in the human dystrophin gene. By simultaneously amplifying genomic regions flanking 17 sepastrate exons in mutational hot spots, we were able to detect 16 exons in one family. The DNA encoding each of the 17 exons in the dystrophin gene is copied a million fold to make it visible in an agarose gel. To be certain that the missing band is not artifact of the amplification procedure, the DNA from the blood sample was analyzed by Southern hybridization.
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