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Minhyun Cho(조민현),Sangjun Yoo(유상준),Juhyun Park(박주현),Chang Wook Jeong(정창욱),Ja Hyeon Ku(구자현),Cheol Kwak(곽철),Hyeon Hoe Kim(김현회),Min Chul Cho(조민철),Hyeon Jeong(정현) 대한비뇨기종양학회 2018 대한비뇨기종양학회지 Vol.16 No.2
Purpose: We evaluated the prognostic value of the 5-tiered grade group in Korean patients who underwent radical prostatectomy. Materials and Methods: Between 1996 and 2016, a number of 2,883 consecutive patients who underwent radical prostatectomy were included for the analysis. The impacts of biopsy and pathologic grade group on predicting biochemical recurrence (BCR) were assessed using multivariate analysis. Median follow-up duration was 49.0 months. Results: Mean age was 66.5 years and prostate-specific antigen (PSA) was 11.8 ng/mL. Prostate cancer was locally advanced on magnetic resonance imaging in 13.4%. Biopsy grade group was as follows: 1 (46.8%), 2(19.8%), 3 (14.2%), 4 (14.1%), and 5 (5.1%). Pathology stage was ≤T2 in 63.6%, T3a in 26.0%, and T3b/T4 in 10.4% patients. Pathologic grade was as follows: 1 (31.3%), 2 (37.9%), 3 (20.2%), 4 (4.7%), and 5 (5.1%). In multivariate analysis using biopsy-related variables, biopsy grade group (1, reference; 2, hazard ratio [HR], 1.771; p=0.001; 3, HR, 2.736; p<0.001; 4, HR, 2.966; p<0.001; 5, HR, 3.707; p<0.001) was associated with BCR-free survival, PSA level and % positive core. In multivariate analysis using pathologic outcomes, pathologic grade group(1, reference; 2, HR, 1.882; p<0.001; 3, HR, 3.352; p<0.001; 4, HR, 3.890; p<0.001; 5, HR: 3.118, p<0.001) was associated with BCR-free survival in addition to pathologic stage and positive surgical margin. Conclusions: New 5-tiered grading system could be useful for predicting oncological outcomes in Korean patients although its role for distinguishing outcomes between patients with grade groups 3.5 need to be validated before wide application of this grade system in Korea.
IMO문서의 효과적 관리를 위한 국내.외 정보시스템 동향 분석
장운재,장승도,조민철,Jang, Woon-Jae,Jang, Seung-Do,Cho, Min-Chul 선박안전기술공단 2012 선박안전 Vol.33 No.-
The Ministry of Land, Transport and Maritime Affairs(MLTM) constructed the IMO Korea homepage to owned jointly IMO information when establishing a international standard in about marine transport and the shipbuilding, in order to speak for the profit of Korea in IMO and it was double renewal since 2004. But the newly re-opened the IMO Korea homepage is also operated to the level which simply keeps IMO documents because of limited H/W sizes. This study investigated and analyzed the domestic and similar foreign homepages to provide effectively about the IMO informations At the result, these homepages were serviced to the meeting resultants using the various contents such as Semantic search, Thesaurus search, establishment of web accessible etc. Therefore, the existing IMO Korea homepage must be re-constructed as IMO Information Portal Site to provide better information.
초.중등 영어교사를 위한 맞춤형 심화 연수 모형 개발 연구
이문복,이노신,조민철,Lee, Moon-Bok,Lee, Noh-Shin,Cho, Min-Chul 한국영어어문교육학회 2010 영어어문교육 Vol.16 No.3
The present study reports on a study of the development of customized intensive in-service English teachers training programs (IIETTP) reflecting on the demands of elementary/secondary school English teachers. For the purpose of study, a survey was conducted with 1,033 English teachers at elementary/secondary schools across the country. The results showed by and large no significant differences by school level, albeit some slight differences were revealed such as in training times, training methods, the percentages of teaching English in English (TEE), and other things. Since the two IIETTP models are presented as basic formats, they can be modified and applied according to the contexts of schools and the demands of trainees.
생기액(生肌液)의 세포독성 및 자궁경부암 바이러스 (HPV 16 type) 암 유발인자 E6와 E7의 작용에 미치는 효과
정옥(Ok Joung),조영식(Young Sik Cho),조정원(Cheong Weon Cho),이경애(Kyung Ae Lee),심정현(Jung Hyun Shim),조민철(Min Chul Cho),이홍수(Hong Soo Lee),염영일(Young Il Yeom),김상범(Sang Bom Kim),박순희(Sue Nie Park),윤도영(Do Young Yoon) 대한약학회 2000 약학회지 Vol.44 No.4
Cervical cancer is one of the leading causes of female death from cancer worldwide with about 500,000 deaths per year. A strong association between certain human papilloma viruses (HPV types 16 and 18) and cervical cancer has been well known. An extract of natural products, named as Somatid, has been used to investigate whether this agent has the ability of inhibiting the oncogenes E6 and E7 of HPV type 16. This Somatid inhibited the proliferation of human cervical cancer cell lines (C-33A, SiHa, CaSki) and HaCaT keratinocytes in a dose response manner. In vitro binding assay and ELISA showed that Somatid inhibited the in vitro biding of E6 and E6AP which are essential for the binding and degradation of the tumor suppressor p53. In addition, Somatid inhibited the in vitro binding of E7 and Rb which is essential tumor suppressor for the control of cell cycle. The levels of mRNA for E6 and E7 were also decreased by Somatid. Our data suggested that Somatid inhibited the oncogenecity of E6 and E7 of HPV 16 type, thus can be used as a putative anti-HPV agent for the treatment of cervical carcinomas caused by HPV.