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RISS 인기검색어
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- 저자 : 정철권(Cheol Kweon Jeung) (검색결과 1 건)
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만성 특발성 두드러기 환자에서 갑상선에 대한 자가항체의 의의
서유진(Yu Jin Suh),정철권(Cheol Kweon Jeung),이수진(Soo Jin Lee),김선신(Sun Sin Kim),이수걸(Soo Keol Lee),남동호(Dong Ho Nahm),박해심(Hae Sim Park) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.3
Background:and objectives: Chronic idiopathic urticaria refers to recurrent hives of more than six weeks duration and in approximately 80% of cases, the etiology is unknown. Recently, involvement of an autoimmune mechanism in the pathogenesis of chronic idiopathic urticaria has been suggested. Thyroid autoimmunity has been reported in patients with chronic idiopathic urticaria and treatment with thyroxine in selected cases induced clinical remission. Materials and methods We studied 99 patients with chronic idiopathic urticaria to evaluate the clinical significance of anti-thyroid auto-antibodies including anti-thyroglobulin and anti-microsomal antibodies. Thirty-four normal volunteers were selected as controls. The prevalence of these two auto-antibodies as well as laboratory findings and clinical features between these two groups were compared. Results: Thyroid auto-antibodies were positive in 24% of patients compared to 8.7% of control patients and the duration of the disease was significantly longer in the patients with thyroid auto-antibodies than in those without thyroid auto-antibodies, respectively(p<0.05). There was no significant difference in age, positive rate of ANA and total eosinophil count. Administration of thyroxine to five patients with refractory urticaria resulted in improvement in three patients. Conclusion: Thyroid autoimmunity is associated with chronic idiopathic urticaria in some patients. Administration of thyroxine resulted in improvement of symptoms in some of these patients. Therefore, we recommend routine testing of thyroid auto-antibodies in patients with retractable chronic idiopathic urticaria.
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