위 내 이물로 오인한 석회화 섬유 종양 1예

정지은,이경훈,성현정,조창호,Jeong, Ji-Eun,Lee, Kyung-Hun,Sung, Hyun-Jung,Cho, Chang-Ho 대한소아소화기영양학회 2009 Pediatric gastroenterology, hepatology & nutrition Vol.12 No.1

평소 복부 팽만을 보인 2세 남아가 내원 3일 전부터 간헐적인 구토를 동반하여 시행한 복부 방사선 사진에서 좌상복부에서 석회화 소견을 관찰하여 상부 위장관내시경과 복부 전산화 단층 사진을 시행하였다. 술 후 병리 검사에서 상당히 빈도가 드문 석회화 섬유 종양을 발견하였기에 보고하는 바이다. Calcifying fibrous tumors (CFTs) are unusual benign tumors of childhood, located primarily in soft tissues, pleura, and peritoneum. The cause and pathogenesis are unclear. We report a rare case of a CFT in a 2-year-old boy who presented with vomiting and abdominal distension. An abdominal X-ray showed an elliptical, calcific shadow in the LUQ area mimicking a foreign body. An internally protruding mass along the lesser curvature of the gastric body was an incidental finding during upper endoscopy, biopsies of which were negative. Abdominal CT showed a 4.5${\times}$3.2 cm soft tissue mass of the gastric wall with calcifications. A diagnosis of gastric submucosal mass was suspected and a wedge resection of the stomach was performed. On microscopic examination, the tumor was composed of whorls of dense hyalinized collagen bundles with a few fibroblasts. There were also amorphous dystrophic calcifications and nodular aggregates of mononuclear inflammatory cells. Immunohistochemically, spindle cells did not stain for anaplastic lymphoma kinase-1 (ALK-1), CK, smooth muscle actin (SMA), or desmin. Taken together, the mass was compatible with a CFT of the gastric wall. This is the first reported case of CFT in a Korean child.

투과 단층촬영에서 공간가변 평활화를 사용한 경계보존 반복연산 재구성

정지은,이수진,Jung, Ji Eun,Ren, Xue,Lee, Soo-Jin 대한의용생체공학회 2017 의공학회지 Vol.38 No.5

Penalized-likelihood (PL) reconstruction methods for transmission tomography are known to provide improved image quality for reduced dose level by efficiently smoothing out noise while preserving edges. Unfortunately, however, most of the edge-preserving penalty functions used in conventional PL methods contain at least one free parameter which controls the shape of a non-quadratic penalty function to adjust the sensitivity of edge preservation. In this work, to avoid difficulties in finding a proper value of the free parameter involved in a non-quadratic penalty function, we propose a new adaptive method of space-variant smoothing with a simple quadratic penalty function. In this method, the smoothing parameter is adaptively selected for each pixel location at each iteration by using the image roughness measured by a pixel-wise standard deviation image calculated from the previous iteration. The experimental results demonstrate that our new method not only preserves edges, but also suppresses noise well in monotonic regions without requiring additional processes to select free parameters that may otherwise be included in a non-quadratic penalty function.

신생아 선별검사를 통해 진단된 1형 타이로신혈증의 NTBC 치료 사례 보고

정지은,김화영,고정민,Ji Eun Jeong,Hwa Young Kim,Jung Min Ko 대한유전성대사질환학회 2023 대한유전성대사질환학회지 Vol.23 No.2

Hereditary tyrosinemia type 1 (HT-1) is a metabolic disorder caused by biallelic pathogenic variants in the fumarylacetoacetate hydrolase (FAH) gene, which impairs the function of the FAH enzyme, resulting in the accumulation of tyrosine's toxic metabolites in hepatocytes and renal tubular cells. As a consequence, individuals with HT-1 exhibit symptomatic manifestations. Rapid diagnosis and treatment of HT-1 can prevent short-term death and long-term complications. A 15-day-old boy presented to the outpatient department with elevated levels of tyrosine on his newborn screening tests conducted at the age of 3 and 10 days, respectively. Further blood tests revealed increased levels of alpha-fetoprotein and amino acids including tyrosine and threonine. Urine organic acid tests indicated a significant elevation in tyrosine metabolites, as well as the presence of succinylacetone (SA), which led to the diagnosis of HT-1. Two pathogenic and likely pathogenic variants of FAH compatible with HT-1 were also detected. He began a tyrosine-restricted diet at one month old and received nitisinone (NTBC) at two months old. With continued treatment, the patient's initially elevated AFP level, detection of SA in the urine, and mild hepatomegaly showed improvement. During four years and seven months of treatment, there were no exceptional complications apart from an increase in tyrosine levels and a delay in speech. We report a case of tyrosinemia type 1 detected through newborn screening, treated with dietary restriction and NTBC, with a good prognosis.

스플라인 정칙자를 사용한 투과 단층촬영을 위한 벌점우도 영상재구성

정지은,이수진,Jung, J.E.,Lee, S.-J. 대한의용생체공학회 2015 의공학회지 Vol.36 No.5

Recently, model-based iterative reconstruction (MBIR) has played an important role in transmission tomography by significantly improving the quality of reconstructed images for low-dose scans. MBIR is based on the penalized-likelihood (PL) approach, where the penalty term (also known as the regularizer) stabilizes the unstable likelihood term, thereby suppressing the noise. In this work we further improve MBIR by using a more expressive regularizer which can restore the underlying image more accurately. Here we used a spline regularizer derived from a linear combination of the two-dimensional splines with first- and second-order spatial derivatives and applied it to a non-quadratic convex penalty function. To derive a PL algorithm with the spline regularizer, we used a separable paraboloidal surrogates algorithm for convex optimization. The experimental results demonstrate that our regularization method improves reconstruction accuracy in terms of both regional percentage error and contrast recovery coefficient by restoring smooth edges as well as sharp edges more accurately.

도시철도 차량부품 표준화를 위한 국내외 사례 및 주요방안제시

정지은(Ji-Eun Jung),양정무(Jung-Moo Yang),김주원(Ju-won Kim),강대현(Dea-Hyun Kang),정효순(Hyo-Soon Jung) 한국철도학회 2016 한국철도학회 학술발표대회논문집 Vol.2016 No.5

현재 국내에서 운영되고 있는 도시철도 차량부품은 다양한 제작사가 납품하며 차량에 따라 사양이 상이하여 차량간의 구성품과 부품에 대한 호환성이 이루어지지 않는 실정이다. 또한 운영기관별로 부품구성체계를 상이하게 관리하고 있어 부품구성체계에 대한 표준화가 전무한 상황이다. 이로인해 철도차량부품 산업이 영세하고 운영기관은 철도차량별 유지보수 체계가 상이하여 시간적 비용과 경제적 비용이 증가하게 된다. 이미 유럽에서는 이러한 문제를 해결하기 위해 표준화를 진행하여 왔으며 유럽규격을 국제규격으로 이행시키는 활동을 병행해왔다. 따라서 국내에서도 표준부품 호환을 위한 부품구성체계 기반마련을 통해 철도차량 부품구성체계와 표준화에 대한 이해가 필요하다. 본 논문은 주요 국외도시철도차량 표준화 규격과 국내 도시철도차량부품 표준화 현황을 분석하고 체계적인 표준화 관리방안을 제시하였다. Today, urban rail vehicles operating in the domestic component will make a variety of delivery. also, vehicle does not vary it made the compatibility of the components and parts of the vehicle. Being a part configured differently for each operating company management is a situation that does not have a standardized system. For this reason, it increases the time and economic costs. In Europe, progress was already standardization and worked to make it an international standard. Therefore, it is necessary to understand the standardized rail cars to provied a BOM based. This paper analyzes the main international urban rail vehicle standard standardization national standardization and proposed a management plan for the systematic standardization.

『에밀』에 나타난 루소의 독서교육론

정지은 ( Ji Eun Jung ),강기수 ( Gi Su Kang ) 한국어린이문학교육학회 2014 어린이문학교육연구 Vol.15 No.2

Rousseau는 아동 교육에 대한 새로운 개념을 『에밀』을 통해 주장하였다. 이런 맥락에서 이 연구는 Rousseau의『에밀』에 나타난 독서교육론을 고찰하고 그 교육적 의의와 한계를 밝히는데 목적을 두었다. 독서교육에 있어서 Rousseau는 언어는 사고에 영향을 미치며 12세 이전의 아동은 관념을 비교할 능력을 갖지 못하고 편견에 쉽게 물들며 감각적인 능력을 통해 사물과 관계를 맺는다는 기본적인 입장을 취하고 있다. 따라서 그는 12세 전의 독서교육에 반대하고, 12세 이후에는 『로빈슨 크루소』를, 15세 이후에는 역사서, 인물전기, 우화, 고전 읽기를 그 내용으로 하였다. 독서교육의 과정은 독서 전에는 동기와 흥미를, 독서 중에는 능동적인 태도를, 그리고 독서 후에는 대화와 적용의 독서 태도를 중시하고 있다. 논의에 근거하여『에밀』에 나타난 Rousseau의 독서교육론의 교육적 의의를 제시하면 우선 Rousseau는 독서를 통해 지적발달을 재촉하는 현대의 부모에게 독서교육의 준비가 중요함을 깨닫게 하고, 정보를 쉽게 접하는 현대의 아동에게 능동적인 독서 태도를 일깨운다. 또한 삶과 연관된 독후 활동을 강조하였고, 아동의 심신의 발달을 배려하며 독서교육을 체계적으로 이끌어 가는 독서지도자의 모습을 강조하였다. 그러나 Rousseau의 독서교육론은 독서 준비를 지나치게 강조한 반면 책 속의 언어가 줄 수 있는 아동의 지적발달을 간과하고 있으며, 소통이 중요시되는 현대 사회에서 사실 중심의 텍스트를 지나치게 강조하고 있다는 점에서 한계를 지니고 있다. This study aimed to study Rousseau`s reading education in "Emile". For this purpose, by means of Rousseau`s reading education, the study attempted to explore educational suggestions and limitations of reading education. He was opposed to teaching literary character to young children and argued for teaching reading content according to developmental stage. In the infant period, he focused on the environment where infants could understand language sufficiently and express. In particular he was opposed to fable education in the childhood period. He only let children read "Robinson Crusoe." And then he allowed the adolescents to read history books, biographies, fables and classics. In this sense, Rousseau focused on reading not for intellectual development but, intellectual development for reading in the decision of reading period. Before reading, he sufficiently motivated and sought active reading to reach one`s own conclusion. And, he emphasized the importance of reviewing books with other people and applying it to one`s own life. Evaluating the findings of the study, the educational implications are as follows. First of all, the reading education of Rousseau suggests that preparation for reading education is important, contrary to contemporary parents who focus on intellectual development. Rousseau argued for the significance of thinking reading and reflection of reading for contemporary children who have easy access to information. Finally, he stresses the significance of the reading instructor`s attitude in the consideration of children`s development and leading reading education systematically. Based on the above argument, the limitations of reading education of Rousseau are as follows. He stressed too much on the preparation for reading. Then, he overlooked the children`s development which can be contributed to by the language of books. Finally, there are limits to applying the reading education of Rousseau to the contemporary point of view.

대추 및 발효대추의 라디칼 소거능 및 모발 성장 촉진 효과

정지은(Ji Eun Jung),조은주(Eun Ju Cho) 한국식품영양과학회 2014 한국식품영양과학회지 Vol.43 No.8

대추와 5개의 균주로 발효시킨 발효대추의 total polyphenol 함량과 in vitro에서의 radical 소거능을 검토한 결과 대추에 비해 발효대추에서의 total polyphenol 함량이 높게 나타났고 DPPH와 ?OH의 소거능이 우수하였으며, 특히 Saccharomyces cerevisiae로 발효시킨 대추가 가장 우수한 효과를 보였다. 이에 대추 추출물과 Sac. cerevisiae로 발효시킨 대추 추출물을 이용하여 C57BL/6N 탈모 마우스실험 모델 하에서 발모 성장 촉진 효과 및 탈모 예방 효과를 검토하였다. 제모 후 EtOH 도포군에서는 거의 발모가 진행되지 않았으나 Zizyphus jujuba(Zj) 도포군과 Sac. cerevisiae-fermented Zj(Zj-Y) 도포군에서는 전체적으로 발모가 진행되었고, 모발의 성장 속도는 minoxidil 도포군>Zj-Y 도포군> Zj 도포군> EtOH 도포군의 순으로 나타났다. 또한 자발적인 탈모에 대한 예방 효과도 대추, 특히 발효대추 도포군에서 우수함을 관찰할 수 있었다. 본 연구 결과로 대추에 비해 발효대추, 특히 Sac. cerevisiae로 발효시킨 대추가 항산화 효능이 뛰어나며, 발모 촉진 효과 및 탈모예방 효과가 우수함을 알 수 있었다. This study investigated the antioxidative and hair growth-promoting activities of Zizyphus jujuba (Zj) and fermented Zj with Aspergillus oryzae, Bacillus subtilis, Bifidobacterium breve, Lactobacillus acidophilus, and Saccharomyces cerevisiae (Sac. cerevisiae). Among Zj and fermented Zjs, Sac. cerevisiae-fermented Zj (Zj-Y) exerted stronger scavenging activity against 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radicals than others. In addition, total polyphenol content of Zj-Y was higher than that of non-fermented Zj and other fermented Zj. This result indicates that fermentation of Zj by Sac. cerevisiae elevated antioxidative activity. Furthermore, using an alopecia model in C57B/6N mice, the hair growth activities of Zj and Zj-Y were investigated. The test samples, EtOH, minoxidil (MXD), Zj, and Zj-Y, were topically treated with 0.2 mL/day for 4 weeks. The experiments involved macroscopic observation and measurement of hair length methods. The results show that regrowth speed of hair was in decreasing order of MXD> Zj-Y> Zj> EtOH. The topical application of MXD and Zj-Y in mice promoted hair regrowth and prevented hair loss compared to the control group. The present study indicates that Zj-Y is a promising treatment for alopecia.

지역예술축제의 거버넌스 구조에 따른 서비스품질과 스토리텔링이 방문객 만족도에 미치는 영향 : 브랜드 자산의 매개효과를 중심으로

정지은(Jung, Ji-Eun) 한국상품학회 2020 商品學硏究 Vol.38 No.2

본 연구에서는 지역예술축제의 운영 주최에 따른 거버넌스 구조에 대해 파악하고, 축제의 브랜드 자산 및 방문객 만족도에 영향을 미치는 주요한 변수인 서비스품질과 스토리텔링의 관계를 통합적으로 살펴보고자 하였다. 따라서 본 연구의 사례를 민간주도의 거창국제연극제와 관주도의 수원연극축제로 선정하였다. 연구의 주요 분석 결과를 요약하면 다음과 같다. 첫째, 지역예술축제(민간주도, 관주도)의 서비스품질은 브랜드 자산에 유의한 양(+)적 영향을 미치는 것으로 나타났으나, 방문객 만족에는 유의한 영향을 미치지 않는 것으로 나타났다. 둘째, 지역예술축제(민간주도, 관주도)의 스토리텔링은 브랜드 자산에 유의한 양(+)적 영향을 미치는 것으로 나타났으나, 방문객 만족에는 유의한 영향을 미치지 않는 것으로 나타났다. 셋째, 각 민간주도 및 관주도 지역예술축제의 서비스품질과 스토리텔링은 모두 브랜드 자산의 완전 매개를 통해 방문객 만족도에 유의한 양(+)적 영향을 미치는 것으로 나타났다. 본 연구는 지역예술축제의 질적인 성장을 촉진하는데 운영 주최를 고려하여 주요 변수들 간에 관계를 살펴보았기에, 관광·상품·문화예술 분야의 학술 및 현장에 시사점을 제공한다. This study was intended to identify the governance structure according to operation principal of local arts festival and to investigate a relationship between service quality and storytelling, the major variables affecting brand asset and satisfaction of visitors in the festival. For these aims, the case studies are selected a privately led Geochang International Festival of Theatre and official Suwon Theatre Festival. The main analysis results of the case studies are summarized as follows. First, it was identified that service quality of local arts festival(privately-driven, government-driven) makes positively affects brand asset but not on satisfaction of visitors. Secondly, it was identified that storytelling of local arts festival(privately-driven, government-driven) makes a significantly positive effect on brand asset, but does not make a significant effect on satisfaction of visitors. Thirdly, it was identified that both service quality and storytelling of privately led and official local arts festival make a significantly positive effect on satisfaction of visitors through the full mediation variable of brand asset. This study provides implications to the academic studies and field of tourism, commodity, and cultural, owing to investigating the relationship between major variables including the central operating body, to promote qualitative growth of local arts festival.

발달장애아동 어머니의 Draw-A-Story 검사반응 특성 연구

정지은 ( Ji Eun Jung ),최은영 ( Eun Yeong Choi ) 한국정신지체아교육학회 2007 지적장애연구 Vol.9 No.1

여가문화 생활만족도와 주관적 웰빙 및 직업 만족도 간의 구조적 관계

정지은(Jieun Jung) 한국상품학회 2023 商品學硏究 Vol.41 No.3