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5'-Untranslated Region에 존재하는 Iron Responsive Element에 의한 Ferritin 합성조절
정인식,이중림,김해영,Chung, In-Sik,Lee, Jung-Lim,Kim, Hae-Yeong 한국응용생명화학회 1998 Applied Biological Chemistry (Appl Biol Chem) Vol.33 No.2
철의 대사과정에 관여하는 ferritin 단백질의 발현은 ferritin transcript의 5'-untranslated region에 위치한 iron-responsive element (IRE)와 철 농도 조절 단백질의 결합에 의해 조절된다. 이러한 ferritin의 생성에 관여하는 구조적인 요소를 밝히기 위해, RNA 이차구조인 IRE의 bulge 부분을 다른 염기로 변환시켜 철 농도 조절단백질에 의한 RNA 결합력과 ferritin 단백질의 생성의 저해정도를 비교 측정하였다. 측정된 결과로부터 IRE의 bulge 부분의 시토신 염기배열만이 RNA 이차구조의 형성에 중요한 작용을 하여 ferritin 합성을 조절할 수 있는 것을 보였다. The expression of ferritin involved in iron metabolism is regulated at the translational level by the interaction of iron regulatory protein with iron-responsive element(IRE) in the 5'-untranslated region of ferritin transcript. To identify the role of structural element utilized for translational regulation of ferritin, we studied the effects of mutations in the ferritin IRE by measuring IRP binding activity and translational activity. Our data suggest that the cytosine at bulged position of IRE within ferritin is important for the formation of RNA secondary structure involved in translational regulation.
볏짚의 Nafion 가수분해물에 대한 Pichia stipitis CBS 5776 의 에탄올 발효
정인식(In Sik Chung),전재근(Jae Kun Chun) 한국응용생명화학회 1994 Applied Biological Chemistry (Appl Biol Chem) Vol.37 No.5
Use of a solid superacid (Nafion) in hydrolysis of rice straw was investigated focusing on the fermentability of the hydrolyzates by Pichia stipitis CBS 5776. Comparisons were made with the hydrolyzates produced by a conventional method of sulfuric acid treatment. The Nafion-catalyzed hydrolyzates of rice straw exhibited low level of inhibition for both cell growth and fermentation in comparison to the hydrolyzates produced by sulfuric acid. Pichia stipitis cells were able to produce ethanol by fermentation of Nafion-catalyzed hydrolyzates when the inoculum level exceeded 3.2 g dry cells/ℓ.
정인식 ( In Sik Chung ),이인석 ( In Seok Lee ),최명규 ( Myung Gyu Choi ),박두호 ( Doo Ho Park ),김상우 ( Sang Woo Kim ),양영상 ( Young Sang Yang ),허원행 ( Won Haing Hur ),조영석 ( Young Seok Jo ),정정조 ( Jung Jo Jung ),김병기 ( 대한소화기학회 2001 대한소화기학회지 Vol.38 No.5
Squamous cell carcinoma of gallbladder is rare and its pathogenesis is unknown. A 63-year-old woman presented with right upper quadrant pain. Investigations revealed irregular and ill-defined heterogenous soft tissue mass in gallbladder fossa, which was infiltrated to the liver, pancreatic head, and duodenum on CT scan. Biopsy of liver and duodenum confirmed it as squamous cell carcinoma. Because the normal gallbladder does not have a squamous epithelium, squamous cell carcinoma of gallbladder has been the subject of interest in several publications. We report a case of squamous cell carcinoma of gallbladder. (Korean J Gastroenterol 2001;38:389- 392)
정인식(In Sik Chung),이원영(Won Young Lee),김재광(Jae Kwang Kim),김응국(Eung Kook Kim),김정수(Jeong Soo Kim),전해명(Hae Myung Jeon),민도준(Do Jun Min),추교영(Gyo Young Chu) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5
Pancreatic duct stones are occasionally seen in the patient with chronic relapsinq pancreatitis. It has various etiologic associations and chronic alcoholism is believed to be the most important etiologic factar among them. Most investigators have considered the panceatic calculi as a complication of the chronic pancreatitis, not as a distinct disease Although the role of pancreatic stone protein is being studied, the pathogenesis of stone formation is not proved. The size of pancreatic stone varies frorn minute, sand-like particles to large solitary or multiplc calculi. The largest stone that has been reported was 4.5cm long. We report a rare case of large staghorn pancreatic duct stone (4.2 cm in length) in a 36-year-old non-alcoholic female without pancreatitis.
Helicobacter pylori에 감염된 십이지장궤양 환자의 벽세포수 및 산분비영역과 위산분비능과의 관계
정인식(In Sik Chung),박두호(Doo Ho Park),최상욱(Sang wook Choi),양영상(Young Sang Yang),최명규(Myung Kyu Choi),김성수(Sung Soo Kim),채현석(Hiun Suk Chae),김상우(Sang Woo Kim),최종영(Jong Young Choi) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.5
N/A Background/Aims: Convincing evidence now exists that Helicobacter pylori (H. pylori) has a pathogenic role in the development of active chronic gastritis and duodenal ulcer (DU). Unlike H. pylori-induced gastritis, the pathophysiology of H. pylori-induced DU is not clearly defined. It has been known that the patients with DU disease tend to secrete acid more than the controls do. To secrete acid more, the density of parietal cells should be increased and/or the oxyntic gland area of gastric mucosa should be well preserved. The present study aims to identify which of the two mechanisms is more relevant to hyperacidity in H. pylori-infected DU patients. Methods: we examined the acid output (basal and pentagastrin-stimulated), the oxyntic area by Congo red chromoscopy, and the number of parietal cells per unit area of the oxyntic gland in H. pylori-infected 20 DU patients and 20 non-ulcer subjects. Results: Basal acid output of DU patients was about 5-fold higher than that of controls (32.3 +- 17.9 vs. 6.1 +- 5.6 mmol/hr, P<0.001). The maximal acid output and peak acid output of DU patients were also approximately 3-fold higher than those of controls, respectively (59.7 +- 29.8 vs. 18.8 +- 18.9 mmol/hr, P=0.001; 73.9 +- 40.1 vs. 23.7 +- 20.6 mmol/hr, P=0.001). Fasting serum gastrin concentration was not significantly different between DU patients and controls. There was a significant difference in the width of oxyntic area between DU patients and controls (P<0.001). Eighty five percent of oxyntic area in DU patients was closed type, whereas 85 % of controls was open type. In DU patients, although the parietal cell density seemed to be higher than that of controls (579 +- 197 vs. 477 +- 204/mm ), the difference was not statistically significant. Peak acid output was well correlated with width of oxyntic area(r=0.568, P=0.002). Conclusions: H. pylori-infected duodenal ulcer patients have hyperacidity owing to rather well-preserved oxyntic area than density of parietal cells. (Korean J Gastroenterol 1997;29:591-600)
한국인에서 Helicobacter pylori 감염의 진단에 있어 Genedia™ H . pylori ELISA 검사의 진단 정확도
정인식(In Sik Chung),김상우(Sang Woo Kim),고재성(Jae Sung Go),김나영(Na Young Kim),김재규(Jae Gyu Kim),김진호(Jin Ho Kim),김학양(Hak Yang Kim),김재준(Jae Jun Kim),노임환(Im Hwan Roe),심재건(Jae Geon Sim),안형식(Hyeong Sik Ahn),윤병철(By 대한내과학회 2001 대한내과학회지 Vol.61 No.1
Background: Genedia™ H. pylori ELISA is a newly developed diagnostic method which detects serum anti-H. pylori IgG antibody. The aim of this study was to assess the accuracy of Genedia™ H. pylori ELISA for the diagnosis of H. pylori infection in Korean population. Methods Genedia : H. pylori ELISA and GAP-IgG were performed in 353 adult sera and Pyloriset-IgG EIA in 184 subjects. In children, 43 serum samples were tested with Genedia™ H. pylori ELISA. H, pylori infection was determined by rapid urease test, histology, culture or (13)C-urea breath test in adults. In children, the subject was considered to he H. pylori positive if (13)C-urea breath test was positive. Results: In adults, the sensitivity and specificity of Genedia™ H. pylori ELISA were 93.2% and 83.5% with positive and negative predictive values of 85.1% and 92.5%. Those for GAP-IgG and Pyloriset-IgG EIA were 67.2%, 82.4%, 79.3%, 71.4% and 89.1%, 88.4%, 71.9%, 96.1%, respectively. In children, sensitivity, specificity, positive and negative predictive values of Genedia™ H. pylori ELISA were 80%, 84.8%, 61.5%, and 93.3%. Sensitivity and negative predictive value of Genedia™ H. pylori ELISA were significantly higher than those of GAP-IgG (93.2% vs. 67.2%, p<0.005 and 92.5% vs 71.4%, p<0.005, respectively). Conclusion : Genedia™ H pylori ELISA is a relatively accurate method for the serodiagnosis of H pylori infection in Korean subjects compared to GAP-IgG. These results may suggest the clinical use of Genedia™ H. pylori ELISA for epidemiological studies of H. pylori infection in Korea. (Korean J Med 61:17-23, 2001)