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Management of gastrointestinal tract perforations
정윤호 소화기인터벤션의학회 2017 Gastrointestinal Intervention Vol.6 No.3
Digestive endoscopy has evolved from primary diagnosis to extensive therapeutic approaches for the management of gastrointestinal diseases. Increased health awareness has encouraged more people to undergo endoscopic examinations. For these reasons, the absolute number of iatrogenic perforations is likely to increase. Because of the very low incidence of perforations, clinicians are not always prepared or experienced in cases of unexpectedly encountered perforations during diagnostic or therapeutic endoscopic procedures. In this study, the proper approach to handling perforations is discussed including selection of endoscopic devices, endoscopic closure procedures, and management of patients after a perforation occurs in the gastrointestinal tract.
말산과 젖산을 부가하여 전기방사한 Poly(vinyl alcohol) 부직포
정윤호,조민석,이운수,길명섭,박병기,김학용,Jung, Yoon-Ho,Cho, Min-Seok,Lee, Un-Soo,Khil, Myung-Seob,Pak, Pyong-Ki,Kim, Hak-Yong 한국섬유공학회 2007 한국섬유공학회지 Vol.44 No.2
Poly(vinyl alcohol) (PVA) solutions were prepared by dissolving PVA in malic acid (MA)/distilled water, lactic acid (LA)/distilled water, and distilled water (DW) as a comparison solvent Viscosity and electric conductivity of PVA solution were determined by using a digital viscometer and electric conductivity' meter at room temperature, respectively. The morphological characteristics of the electrospun PVA nonwoven mats were investigated with a scanning electron microscopy (SEM) after gold sputtering. Also, mechanical properties of electrospun PVA nonwoven mats were measured by a universal testing machine (UTM). SEM results indicated that the electrospun fibers prepared from 4 wt% MA/DW as a solvent showed highly entangled structure due to their bent shape, which resulted in high mechanical strength of electrospun PVA nonwoven mats. Tensile strength and breaking elongation of electrospun PVA fibers prepared from 4 wt% MA/DW were over 12 MPa and 420%, respectively.
정윤호,이상민 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
We indicate elaborate alteration of colloidal architecture self-associated from block-copolymer excipients with versatile molecular geometry, which leads to the different kinetic properties for the pH-triggered release of cisplatin. Atom-transfer radical polymerization was employed as a controlled synthetic method for the block-copolymer, which comprise the cisplatin-binding poly(acrylic acid) block joined either a small mPEG-grafted poly(methacrylate) to generate a brush-type structure or a simple linear mPEG segment. Upon the coordination of Pt<sup>II</sup> as an active pharmacophore of cisplatin, the resulting Pt<sup>II</sup>-encapsulated nanoparticles exhibited micelle-like core/shell structures with various kinetic properties for Pt<sup>II</sup>-mediated self-association as well as acid-triggered drug release processes, which further allows us to explore the molecular geometry-colloidal property relationship through the structural determination of colloidal architecture.