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유전자 재조합 Human Growth Hormone 의 성장촉진 효과에 관한 연구
정요찬(Yo Chan Jeong),송동호(Dong Ho Song),조명행(Myung Haing Cho),구본흔(Bon Heun Koo),정광회(Kwang Hoe Chung),김경연(Kyeong Yeon Kim),정경환(Kyung Hwan Jung),이은경(Eun Kyung Lee),박두홍(Doo Hong Park) 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.3
The growth effects of newly developed recombinant human growth hormone (rHGH), were compared with those of Biotropine. For the effective evaluation, we examined the increasing rate of body weight and the thicknes of tibial epiphysis as criteria of growth effects on hypophysectomised female rats treated with varing concentration of rHGH for 4 days. rHGH treated groups showed significant body weight gain which was less evident in Biotropine and vehicle treatment group. In tibial epiphyseal test, rHGH also showed clear effects compared to Biotropine and vehicle treatment group. Above findings indicate that newly developed rHGH has better effects of growth stimulation on female rats than Biotropine does.
정요찬(Yo Chan Jeong),윤효인(Hyo In Yun),조명행(Myung Haing Cho),박병권(Byung Kweon Park),박일현(Il Hyun Park),김복환(Bok Hwan Kim),송동호(Dong Ho Song) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.3
The purpose of this study was to determine pharmacokinetic parameters and tissue distribution pattern of urinary trypsin inhibitor(UTI) in Sprague-Dawley rats. Na^(125)I was conjugated to UTI to make ^(125)I-UTI and the concentrations were determined by γ counter. With the aid of nonlinear least-square regression analysis for i.v. bolus injection of 1,000 unit UTI including ^(125)I-UTI, the temporal concentration curves were best fitted by 2-compartment open model. The distribution phase half-life was 0.39±0.02 hours whereas the elimination half-life was 12.99±1.05 hours in male rats. The volume of distribution and total body clearance in male rats were 0.28±0.01 l/kg and 83.16±1.15 ml/kg/h, respectively. We could not find any difference of pharmacokinetic parameters of UTI between male and female rats. UTI were distributed widely in rat organs. In both male and female rats, the kidney was the highest distributed organ. Amount of UTI in 24 hour cumulative urine in male rats was 36.22±8.74% and that in 48 hours was 43.32±10.55%. Excretion via feces was very scanty, with the 24 hours cumulative amount being only 2.76±0.97%. This data suggest the main excretion route of UTI is urine.
오줌유래 Trypsin 효소 억제제가 췌장염에 미치는 영향에 관한 연구
조명행(Myung Haing Cho),권오경(Oh Kyung Kweon),정요찬(Yo Chan Jeong),유아선(Ah Sun You),김종민(Jong Min Kim),박수진(Soo Jin Park),송동호(Dong Ho Song) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.3
The metabolism of carbinoxamine, 2-[(4-chlorophenyl)-2-pyridinyl-methoxy]-N, N-dimethylethaneamine, was studied in adult male volunteers after an oral dose of 15 mg. Solvent extracts of urine obtained with or without enzyme hydrolysis were analyzed by gas chromatography-mass spectrometry after derivatization with MSTFA/TMSCl (N-methyl-N-trimethylsilyltrifluoroacetamide/trimethyl chlorosilane). The structures of metabolites were determined based on the electron impact (EI) and chemical ionization (CI) mass spectra. Nonconjugated metabolites identified in the urine were carbinoxamine, nor-carbinoxamine, and bis-nor-carbinoxamine. Parent drug, nor-carbinoxamine, and bis-nor-carbinoxamine were also detected as conjugated forms. These metabolites observed in human urine were different from those previously reported in the rat. Urinary excretions of carbinoxamine were reached to maxima in 4 hours after drug administration with 4.9%-8.1% and 2.5-4.2% of the dose excreted during 24 h as carbinoxamine and its glucuronide, respectively.